{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:53:54Z","timestamp":1793325234220,"version":"4.5.0"},"reference-count":117,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients\u2019 quality of life and strongly interfere with sleep, social, and work activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-31, IL-25, and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes, and type 2 T lymphocytes, and are master regulators of chronic itch. These cytokines might act as direct pruritogen on primary sensory neurons (pruriceptors) or alter the sensitivity to other itch mediators Type 2 inflammation- and immunity-dominated skin diseases, including atopic dermatitis, prurigo nodularis, bullous pemphigoid, scabies, parasitic diseases, urticaria, and S\u00e9zary syndrome are indeed conditions associated with most severe pruritus. In contrast, in other skin diseases, such as scleroderma, lupus erythematosus, hidradenitis suppurativa, and acne, type 2 inflammation is less represented, and pruritus is milder or variable. Th2 inflammation and immunity evolved to protect against parasites, and thus, the scratching response evoked by pruritus might have developed to alert about the presence and to remove parasites from the skin surface.<\/jats:p>","DOI":"10.3390\/vaccines9030303","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T23:59:41Z","timestamp":1616543981000},"page":"303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Pruritus as a Distinctive Feature of Type 2 Inflammation"],"prefix":"10.3390","volume":"9","author":[{"given":"Simone","family":"Garcovich","sequence":"first","affiliation":[{"name":"Dermatology, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Dermatology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-8010","authenticated-orcid":false,"given":"Martina","family":"Maurelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-9001","authenticated-orcid":false,"given":"Paolo","family":"Gisondi","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Dermatology, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Dermatology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[{"name":"Miami Itch Center, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-0493","authenticated-orcid":false,"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, 37126 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000446010","article-title":"Epidemiology of Itch","volume":"50","author":"Weisshaar","year":"2016","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2340\/00015555-1572","article-title":"Incidence and Determinants of Chronic Pruritus: A Population-based Cohort Study","volume":"93","author":"Matterne","year":"2013","journal-title":"Acta Derm. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical Classification of Itch: A Position Paper of the International Forum for the Study of Itch","volume":"87","author":"Weisshaar","year":"2007","journal-title":"Acta Derm. Venereol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/jdv.14673","article-title":"Immune Response Patterns in Non-communicable Inflammatory Skin Diseases","volume":"32","author":"Eyerich","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The Immunological Anatomy of the Skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.it.2019.12.004","article-title":"Skin-Resident Innate Lymphoid Cells\u2013Cutaneous Innate Guardians and Regulators","volume":"41","author":"Kobayashi","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: From Mechanism to (Novel) Therapeutic Approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Najafi, P., Dufor, O., Ben Salem, D., Misery, L., and Carr\u00e9, J.-L. (2020). Itch Processing in the Brain. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.17029"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000446011","article-title":"Central Mechanisms of Itch","volume":"50","author":"Carstens","year":"2016","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-3-662-46450-2_14","article-title":"Itch and Pain Differences and Commonalities","volume":"227","author":"Schmelz","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jdermsci.2015.06.004","article-title":"Experimental Elicitation of Itch: Evoking and Evaluation Techniques","volume":"80","author":"Fostini","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.1900818","article-title":"Unraveling the Plastic Peripheral Neuroimmune Interactome","volume":"204","author":"Jain","year":"2020","journal-title":"J. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ana.25912","article-title":"Keratinocytes Communicate with Sensory Neurons via Synaptic-like Contacts","volume":"88","author":"Talagas","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/jdv.15973","article-title":"Neuroimmune Interactions in Chronic Itch of Atopic Dermatitis","volume":"34","author":"Yosipovitch","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-662-44605-8_10","article-title":"Interactions between Keratinocytes and Somatosensory Neurons in Itch","volume":"226","author":"Wilson","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E7572","DOI":"10.1073\/pnas.1606608113","article-title":"IL-33\/ST2 Signaling Excites Sensory Neurons and Mediates Itch Response in a Mouse Model of Poison Ivy Contact Allergy","volume":"113","author":"Liu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The Epithelial Cell-derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/exd.12828","article-title":"Increase in Pruritogenic Kallikrein 5 in the Skin of NC Mice with Chronic Dermatitis","volume":"24","author":"Andoh","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jid.2019.10.022","article-title":"Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation","volume":"140","author":"Guo","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7864","DOI":"10.1038\/ncomms8864","article-title":"Redefining the Concept of Protease-activated Receptors: Cathepsin S Evokes Itch via Activation of Mrgprs","volume":"6","author":"Reddy","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100032","DOI":"10.1016\/j.ynpai.2019.100032","article-title":"Cathepsin S Acts via Protease-activated Receptor 2 to Activate Sensory Neurons and Induce Itch-like Behaviour","volume":"6","author":"Chung","year":"2019","journal-title":"Neurobiol. Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107472","DOI":"10.1016\/j.celrep.2020.03.036","article-title":"Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch","volume":"31","author":"Mishra","year":"2020","journal-title":"Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1172\/JCI58978","article-title":"Periostin Promotes Chronic Allergic Inflammation in Response to Th2 Cytokines","volume":"122","author":"Masuoka","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/exd.14034","article-title":"Interleukin-4 and Interleukin-13 Evoke Scratching Behaviour in Mice","volume":"28","author":"Campion","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cyto.2015.05.008","article-title":"The Differential Expression of IL-4 and IL-13 and Its Impact on Type-2 Immunity","volume":"75","author":"Bao","year":"2015","journal-title":"Cytokine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","article-title":"IL-31: A New Link between T Cells and Pruritus in Atopic Skin Inflammation","volume":"117","author":"Sonkoly","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A Sensory Neuron-expressed IL-31 Receptor Mediates T Helper Cell-dependent Itch: Involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cytogfr.2008.08.003","article-title":"Structures and Biological Functions of IL-31 and IL-31 Receptors","volume":"19","author":"Zhang","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/imr.12558","article-title":"IL-25 in Allergic Inflammation","volume":"278","author":"Xu","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cytogfr.2017.09.005","article-title":"Pathophysiology of IL-33 and IL-17 in Allergic Disorders","volume":"38","author":"Gupta","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Thangam, E.B., Jemima, E.A., Singh, H., Baig, M.S., Khan, M., Mathias, C.B., Church, M.K., and Saluja, R. (2018). The Role of Histamine and Histamine Receptors in Mast Cell-mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01873"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/all.12316","article-title":"Interleukin-31 Does not Induce Immediate Itch in Atopic Dermatitis Patients and Healthy Controls after Skin Challenge","volume":"69","author":"Hawro","year":"2014","journal-title":"Allergy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.62.2.212","article-title":"Painful Stimuli Evoke Itch in Patients with Chronic Pruritus: Central Sensitization for Itch","volume":"62","author":"Ikoma","year":"2004","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ejpain.2006.03.005","article-title":"Chronic Itch and Pain - Similarities and Differences","volume":"10","author":"Schmelz","year":"2006","journal-title":"Eur. J. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jid.2019.05.029","article-title":"Peripheral Sensitization and Loss of Descending Inhibition Is a Hallmark of Chronic Pruritus","volume":"140","author":"Pereira","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/j.pain.0000000000001220","article-title":"Alloknesis and Hyperknesis-mechanisms, Assessment Methodology, and Clinical Implications of Itch Sensitization","volume":"159","author":"Andersen","year":"2018","journal-title":"Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1097\/j.pain.0000000000001678","article-title":"Itch Sensitization? A Systematic Review of Studies Using Quantitative Sensory Testing in Patients with Chronic Itch","volume":"160","author":"Marker","year":"2019","journal-title":"Pain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The Itch\u2013Scratch Cycle: A Neuroimmune Perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaci.2016.02.020","article-title":"The Pruritus- and TH2-associated Cytokine IL-31 Promotes Growth of Sensory Nerves","volume":"138","author":"Feld","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1346-8138.12317","article-title":"Itch and Nerve Fibers with Special Reference to Atopic Dermatitis: Therapeutic Implications","volume":"41","author":"Tominaga","year":"2014","journal-title":"J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.4049\/jimmunol.1300300","article-title":"TRPA1-Dependent Pruritus in IL-13\u2013Induced Chronic Atopic Dermatitis","volume":"191","author":"Oh","year":"2013","journal-title":"J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/apm.12934","article-title":"Personalized Medicine-concepts, Technologies, and Applications in Inflammatory Skin Diseases","volume":"127","author":"Litman","year":"2019","journal-title":"APMIS"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaci.2020.05.009","article-title":"Mechanisms of Skin Autoimmunity: Cellular and Soluble Immune Components of the Skin","volume":"146","author":"Gudjonsson","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/jdv.16003","article-title":"The Patient-reported Disease Burden in Adults with Atopic Dermatitis: A Cross-sectional Study in Europe and Canada","volume":"34","author":"Gadkari","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/14728214.2020.1801632","article-title":"Emerging Drugs for the Treatment of Chronic Pruritic Diseases","volume":"25","author":"Fourzali","year":"2020","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-3024.2010.01218.x","article-title":"The Immunology of Susceptibility and Resistance to Scabies","volume":"32","author":"Walton","year":"2010","journal-title":"Parasite Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1645\/GE-214R","article-title":"Skewed Th1\/Th2 Immune Response to Sarcoptes scabiei","volume":"90","author":"Lalli","year":"2004","journal-title":"J. Parasitol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1128\/CVI.00195-10","article-title":"Increased Allergic Immune Response to Sarcoptes scabiei Antigens in Crusted versus Ordinary Scabies","volume":"17","author":"Walton","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s13071-017-2320-4","article-title":"Host Immune Responses to the Itch Mite, Sarcoptes scabiei, in Humans","volume":"10","author":"Bhat","year":"2017","journal-title":"Parasit. Vectors"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"He, R., Gu, X., Lai, W., Peng, X., and Yang, G. (2017). Transcriptome-microRNA Analysis of Sarcoptes scabiei and Host Immune Response. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177733"},{"key":"ref_52","first-page":"1","article-title":"Itch in Scabies\u2014What Do We Know?","volume":"8","year":"2021","journal-title":"Front. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Mounsey, K.E., Murray, H.C., Bielefeldt-Ohmann, H., Pasay, C., Holt, D.C., Currie, B.J., Walton, S.F., and McCarthy, J.S. (2015). Prospective Study in a Porcine Model of Sarcoptes scabiei Indicates the Association of Th2 and Th17 Pathways with the Clinical Severity of Scabies. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003498"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/all.13870","article-title":"Pruritus in Ordinary Scabies: IL-31 from Macrophages Induced by Overexpression of Thymic Stromal Lymphopoietin and Periostin","volume":"74","author":"Hashimoto","year":"2019","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jid.2018.09.032","article-title":"Non-Histaminergic Itch Mediators Elevated in the Skin of a Porcine Model of Scabies and of Human Scabies Patients","volume":"139","author":"Sanders","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/PAP.0000000000000183","article-title":"Parasitic Infections of the Skin and Subcutaneous Tissues","volume":"25","author":"Norgan","year":"2018","journal-title":"Adv. Anat. Pathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.12788\/j.sder.0108","article-title":"Helminths: A Clinical Review and Update","volume":"33","author":"Prickett","year":"2014","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jaad.2016.04.032","article-title":"Emerging Infectious Diseases with Cutaneous Manifestations: Fungal, Helminthic, Protozoan and Ectoparasitic Infections","volume":"75","author":"Kollipara","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1017\/S0031182017000488","article-title":"The Role of Rare Innate Immune Cells in Type 2 Immune Activation Against Parasitic Helminths","volume":"144","author":"Webb","year":"2017","journal-title":"Parasitology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110257","DOI":"10.1016\/j.mehy.2020.110257","article-title":"Mites, Ticks, Anaphylaxis and allergy: The Acari Hypothesis","volume":"144","author":"Retzinger","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1080\/23744235.2016.1194529","article-title":"Molecular Events by Which Dendritic Cells Promote Th2 Immune Protection in Helmith Infection","volume":"48","year":"2016","journal-title":"Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2016.04.010","article-title":"Clinical Categories of Exaggerated Skin Reactions to Mosquito Bites and Their Pathophysiology","volume":"82","author":"Tatsuno","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.en.29.010184.000403","article-title":"Allergic and Toxic Reactions to Non-stinging Arthropods","volume":"29","author":"Wirtz","year":"1984","journal-title":"Annu. Rev. Entomol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1254\/jjp.86.97","article-title":"Roles of Mast Cells and Histamine in Mosquito Bite-induced Allergic Itch-associated Responses in Mice","volume":"86","author":"Ohtsuka","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.immuni.2013.10.015","article-title":"A Sting in the Tale of TH2 Immunity","volume":"39","author":"Gutierrez","year":"2013","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12016-017-8597-4","article-title":"Immunology of Bee Venom","volume":"54","author":"Shafaghat","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/eji.1830270513","article-title":"Insect Venom Immunotherapy Induces Interleukin-10 Production and a Th2-to-Th1 Shift, and Changes Surface Marker Expression in Venom-allergic Subjects","volume":"27","author":"Bellinghausen","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/all.13401","article-title":"Epidemiology of Atopic Dermatitis in Adults: Results from an International Survey","volume":"73","author":"Barbarot","year":"2018","journal-title":"Allergy"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1080\/09546634.2019.1612836","article-title":"Dupilumab Improves Patient-reported Symptoms of Atopic Dermatitis, Symptoms of Anxiety and Depression, and Health-related Quality of Life in Moderate-to-severe Atopic Dermatitis: Analysis of Pooled Data from the Randomized Trials SOLO 1 and SOLO 2","volume":"31","author":"Cork","year":"2020","journal-title":"J. Dermatolog. Treat."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clindermatol.2013.11.007","article-title":"Atopic Dermatitis as a Systemic Disease","volume":"32","author":"Darlenski","year":"2014","journal-title":"Clin. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2020.06.012","article-title":"Atopic Dermatitis Displays Stable and Dynamic Skin Transcriptome Signatures","volume":"147","author":"Rodriguez","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/ITT.S260370","article-title":"Targeting IL-4 for the Treatment of Atopic Dermatitis","volume":"9","author":"Chiricozzi","year":"2020","journal-title":"ImmunoTargets Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2019.11.047","article-title":"Progression of Acute-to-chronic Atopic Dermatitis is Associated with Quantitative Rather Than Qualitative Changes in Cytokine Responses","volume":"145","author":"Tsoi","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jid.2018.12.018","article-title":"Atopic Dermatitis is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis","volume":"139","author":"Tsoi","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tubau, C., and Puig, L. (2020). Therapeutic Targeting of the IL-13 Pathway in Skin Inflammation. Expert Rev. Clin. Immunol., 1\u201311.","DOI":"10.1080\/1744666X.2020.1858802"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Xuemin, X., Lihang, L., Changhua, Z., Xiaofang, Y., Yongshan, N., Zhipeng, L., Chong, J., and Yue, H. (2021). Efficacy and Safety of Nemolizumab for Adult Atopic Dermatitis Treatment: A Meta-analysis of Randomized Clinical Trials. J. Investig. Allergol. Clin. Immunol., 31.","DOI":"10.18176\/jiaci.0672"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Cartron, A.M., Nguyen, T.H., Roh, Y.S., Kwatra, M.M., and Kwatra, S.G. (2021). JAK Inhibitors for Atopic Dermatitis: A Promising Treatment Modality. Clin. Exp. Dermatol.","DOI":"10.1111\/ced.14567"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/jdv.14570","article-title":"European Academy of Dermatology and Venereology European Prurigo Project: Expert Consensus on the Definition, Classification and Terminology of Chronic Prurigo","volume":"32","author":"Pereira","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jaad.2018.04.047","article-title":"Ethnic Differences and Comorbidities of 909 Prurigo Nodularis Patients","volume":"79","author":"Boozalis","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1111\/jdv.16309","article-title":"Chronic Nodular Prurigo: Clinical Profile and Burden. A European Cross-sectional Study","volume":"34","author":"Pereira","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1684\/ejd.2010.1196","article-title":"Increased Expression of mRNAs for IL-4, IL-17, IL-22 and IL-31 in Skin Lesions of Subacute and Chronic Forms of Prurigo","volume":"21","author":"Park","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2340\/00015555-3150","article-title":"Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis","volume":"99","author":"Zhong","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"adv00375","DOI":"10.2340\/00015555-3702","article-title":"Dermal Periostin: A New Player in Itch of Prurigo Nodularis","volume":"101","author":"Hashimoto","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0560.2000.027007359.x","article-title":"CGRP-immunoreactive Nerves in Prurigo Nodularis\u2013an Exploration of Neurogenic Inflammation","volume":"27","author":"Liang","year":"2000","journal-title":"J. Cutan. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00403-001-0285-8","article-title":"Increased Nerve Growth Factor- and Tyrosine Kinase A-like Immunoreactivities in Prurigo Nodularis Skin\u2013an Exploration of the Cause of Neurohyperplasia","volume":"293","author":"Johansson","year":"2002","journal-title":"Arch. Dermatol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Hashimoto, T., Nattkemper, L.A., Kim, H.S., Kursewicz, C.D., Fowler, E., Shah, S.M., Nanda, S., Fayne, R.A., Paolini, J.F., and Romanelli, P. (2021). Itch Intensity in Prurigo Nodularis is Closely Related to Dermal Interleukin-31, Oncostatin M, IL-31 Receptor Alpha and Oncostatin M Receptor Beta. Exp. Dermatol.","DOI":"10.1111\/exd.14279"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaad.2020.03.049","article-title":"Dupilumab Improves Clinical Manifestations, Symptoms, and Quality of Life in Adult Patients with Chronic Nodular Prurigo","volume":"83","author":"Chiricozzi","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJMoa1908316","article-title":"Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis","volume":"382","author":"Yosipovitch","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/cup.12673","article-title":"Identification of a Th2- and Th17-skewed Immune Phenotype in Chronic Urticaria with Th22 Reduction Dependent on Autoimmunity and Thyroid Disease Markers","volume":"43","author":"Moy","year":"2016","journal-title":"J. Cutan. Pathol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Murdaca, G., Greco, M., Tonacci, A., Negrini, S., Borro, M., Puppo, F., and Gangemi, S. (2019). IL-33\/IL-31 Axis in Immune-Mediated and Allergic Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235856"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/cea.12875","article-title":"Human Basophils are a Source of - and are Differentially Activated by - IL-31","volume":"47","author":"Raap","year":"2017","journal-title":"Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.anai.2019.08.014","article-title":"New Treatments for Chronic Urticaria","volume":"124","author":"Kolkhir","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/09546634.2019.1689227","article-title":"Dupilumab Use in Dermatologic Conditions Beyond Atopic Dermatitis - a Systematic Review","volume":"32","author":"Hendricks","year":"2021","journal-title":"J. Dermatolog. Treat."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Bellinato, F., Maurelli, M., Schena, D., Gisondi, P., and Girolomoni, G. (2020). Clinical and Immunological Profile of Patients with Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid. G. Ital. Dermatol. Venereol. Organo Uff. Soc. Ital. Dermatol. Sifilogr.","DOI":"10.23736\/S2784-8671.20.06562-1"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.3389\/fimmu.2019.02331","article-title":"The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid","volume":"10","author":"Messingham","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1684\/ejd.2018.3366","article-title":"Immunoglobulin E and Bullous Pemphigoid","volume":"28","author":"Cozzani","year":"2018","journal-title":"Eur. J. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Tabatabaei-Panah, P.-S., Moravvej, H., Alirajab, M., Etaaty, A., Geranmayeh, M., Hosseine, F., Khansari, A., Mahdian, M., Mirhashemi, M., and Parvizi, S. (2020). Association between TH2 Cytokine Gene Polymorphisms and Risk of Bullous Pemphigoid. Immunol. Investig., 1\u201313.","DOI":"10.1080\/08820139.2020.1832113"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2340\/00015555-2951","article-title":"Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid","volume":"98","author":"Gehring","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaad.2019.07.060","article-title":"Pathophysiologic Mechanisms of Itch in Bullous Pemphigoid","volume":"83","author":"Hashimoto","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaad.2020.01.089","article-title":"Dupilumab as a Novel Therapy for Bullous Pemphigoid: A Multicenter Case Series","volume":"83","author":"Abdat","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_101","unstructured":"(2021, February 16). A Study to Investigate the Use of Benralizumab in Patients with Bullous Pemphigoid, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04612790."},{"key":"ref_102","unstructured":"(2021, February 16). A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients with Bullous Pemphigoid, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04206553."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1684\/ejd.2017.3183","article-title":"Incidence and Ten-year Follow-up of Primary Cutaneous Lymphomas: A Single-centre Cohort Study","volume":"28","author":"Maurelli","year":"2018","journal-title":"Eur. J. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/1346-8138.13083","article-title":"New Aspects of the Clinicopathological Features and Treatment of Mycosis Fungoides and S\u00e9zary Syndrome","volume":"42","author":"Furue","year":"2015","journal-title":"J. Dermatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/jdv.15075","article-title":"Inflammatory Cytokines and Peripheral Mediators in the Pathophysiology of Pruritus in Cutaneous T-cell Lymphoma","volume":"32","author":"Lewis","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1158\/0008-5472.CAN-16-0992","article-title":"Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma","volume":"76","author":"Takahashi","year":"2016","journal-title":"Cancer Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/bjd.16237","article-title":"Interleukin-25 is Involved in Cutaneous T-cell Lymphoma Progression by Establishing a T helper 2-dominant Microenvironment","volume":"178","author":"Nakajima","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1684\/ejd.2019.3560","article-title":"Mechanisms of Itching in Mycosis Fungoides: Grade of Itching Correlates with Eosinophil Infiltration and Kallikrein 5 Expression","volume":"29","author":"Shimizu","year":"2019","journal-title":"Eur. J. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2340\/00015555-2417","article-title":"Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin","volume":"96","author":"Nattkemper","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2015.02.014","article-title":"Improved Pruritus Correlates with Lower Levels of IL-31 in CTCL Patients under Different Therapeutic Modalities","volume":"158","author":"Singer","year":"2015","journal-title":"Clin. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Steck, O., Bertschi, N.L., Luther, F., van den Berg, J., Winkel, D.J., Holbro, A., and Schlapbach, C. (2020). Rapid and Sustained Control of Itch and Reduction in Th2 Bias by Dupilumab in a Patient with S\u00e9zary Syndrome. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.17001"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.jaad.2019.06.038","article-title":"Chronic Pruritus of Unknown Origin (CPUO): Uniform Nomenclature and Diagnosis as a Pathway to Standardized Understanding and Treatment","volume":"81","author":"Kim","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Andrade, A., Kuah, C.Y., Martin-Lopez, J.E., Chua, S., Shpadaruk, V., Sanclemente, G., and Franco, J.V.A. (2020). Interventions for Chronic Pruritus of Unknown Origin. Cochrane Database Syst. Rev., 2020.","DOI":"10.1002\/14651858.CD013128.pub2"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Roh, Y.S., Khanna, R., Patel, S.P., Gopinath, S., Williams, K.A., Khanna, R., Pritchard, T., Sutaria, N., Choi, J., and Alphonse, M.P. (2021). Circulating Blood Eosinophils as a Biomarker for Variable Clinical Presentation and Therapeutic Response in Patients with Chronic Pruritus of Unknown Origin. J. Allergy Clin. Immunol. Pract.","DOI":"10.1016\/j.jaip.2021.01.034"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Zhai, L.L., Savage, K.T., Qiu, C.C., Jin, A., Valdes-Rodriguez, R., and Mollanazar, N.K. (2019). Chronic Pruritus Responding to Dupilumab\u2014A Case Series. Medicines, 6.","DOI":"10.3390\/medicines6030072"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1177271920940712","DOI":"10.1177\/1177271920940712","article-title":"Interleukin-31 and Chronic Pruritus of Unknown Origin","volume":"15","author":"Salao","year":"2020","journal-title":"Biomark. Insights"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Wang, F., Morris, C., Bodet, N.D., and Kim, B.S. (2019). Treatment of Refractory Chronic Pruritus of Unknown Origin With Tofacitinib in Patients With Rheumatoid Arthritis. 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