{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:28:47Z","timestamp":1791239327258,"version":"4.1.0"},"reference-count":144,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Due to the aging population, modern society is facing an increasing prevalence of neurological diseases such as Alzheimer\u2019s disease (AD). AD is an age-related chronic neurodegenerative disorder for which no satisfying therapy exists. Understanding the mechanisms underlying the onset of AD is necessary to find targets for protective treatment. There is growing awareness of the essential role of the immune system in the early AD pathology. Amyloidopathy, the main feature of early-stage AD, has a deregulating effect on the immune function. This is reciprocal as the immune system also affects amyloidopathy. It seems that the inflammatory reaction shows a heterogeneous pattern depending on the stage of the disease and the variation between individuals, making not only the target but also the timing of treatment important. The lack of relevant translational animal models that faithfully reproduce clinical and pathogenic features of AD is a major cause of the delay in developing new disease-modifying therapies and their optimal timing of administration. This review describes the communication between amyloidopathy and inflammation and the possibility of using nonhuman primates as a relevant animal model for preclinical AD research.<\/jats:p>","DOI":"10.3390\/vaccines9040388","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T21:35:13Z","timestamp":1618522513000},"page":"388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Preclinical Marmoset Model for Targeting Chronic Inflammation as a Strategy to Prevent Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"9","author":[{"given":"Ingrid H. C. H. M.","family":"Philippens","sequence":"first","affiliation":[{"name":"Animal Science Department, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-4412","authenticated-orcid":false,"given":"Jan A. M.","family":"Langermans","sequence":"additional","affiliation":[{"name":"Animal Science Department, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands"},{"name":"Department Population Health Sciences, Unit Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"(2016). Alzheimer\u2019s disease facts and figures. 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