{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:26:16Z","timestamp":1779927976748,"version":"3.53.1"},"reference-count":258,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The medical and veterinary public health importance of ticks and tick-borne pathogens is increasing due to the expansion of the geographic ranges of both ticks and pathogens, increasing tick populations, growing incidence of tick-borne diseases, emerging tick transmitted pathogens, and continued challenges of achieving effective and sustained tick control. The past decades show an increasing interest in the immune-mediated control of tick infestations and pathogen transmission through the use of vaccines. Bovine tick resistance induced by repeated infestations was reported over a century ago. This review addresses the phenomena and immunological underpinning of resistance to tick infestation by livestock and laboratory animals; the scope of tick countermeasures to host immune defenses; and the impact of genomics, functional genomics, and proteomics on dissecting complex tick\u2013host\u2013pathogen interactions. From early studies utilizing tick tissue extracts to salivary gland derived molecules and components of physiologically important pathways in tick gut and other tissues, an increased understanding of these relationships, over time, impacted the evolution of anti-tick vaccine antigen selection. Novel antigens continue to emerge, including increased interest in the tick microbiome. Anti-tick and transmission blocking vaccines targeting pathogen reservoirs have the potential to disrupt enzootic cycles and reduce human, companion, domestic animal, and wildlife exposure to infected ticks.<\/jats:p>","DOI":"10.3390\/vaccines9070725","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T22:35:22Z","timestamp":1625438122000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Resistance to Ticks and the Path to Anti-Tick and Transmission Blocking Vaccines"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2282-6121","authenticated-orcid":false,"given":"Jolieke G.","family":"van Oosterwijk","sequence":"first","affiliation":[{"name":"US Biologic Inc., 20 Dudley Street, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Wikel","sequence":"additional","affiliation":[{"name":"US Biologic Inc., 20 Dudley Street, Memphis, TN 38103, USA"},{"name":"Department of Medical Sciences, School of Medicine, Quinnipiac University, Hamden, CT 06518, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2004","journal-title":"Parasitology."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ijppaw.2015.07.001","article-title":"Climate changes, biodiversity, ticks and tick-borne diseases: The butterfly effect","volume":"4","year":"2015","journal-title":"Int. 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