{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:33:46Z","timestamp":1771878826921,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Southern Medical University; Scientific Research Foundation of Zhejiang University City College","award":["C1034211 and C1051004; J-202106"],"award-info":[{"award-number":["C1034211 and C1051004; J-202106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Zika virus (ZIKV) is an arbovirus first discovered in the Americas. ZIKV infection is insidious based on its mild clinical symptoms observed after infection. In Brazil, after 2015, ZIKV infection broke out on a large scale, and many infected pregnant women gave birth to babies with microcephaly. The teratogenic effects of the virus on the fetus and its effects on nerves and the immune system have attracted great attention. Currently, no specific prophylactics or therapeutics are clinically available to treat ZIKV infection. Development of a safe and effective vaccine is essential to prevent the rise of any potential pandemic. In this review, we summarize the latest research on Zika vaccine development based on different strategies, including DNA vaccines, subunit vaccines, live-attenuated vaccines, virus-vector-based vaccines, inactivated vaccines, virus-like particles (VLPs), mRNA-based vaccines, and others. We anticipate that this review will facilitate further progress toward the development of effective and safe vaccines against ZIKV infection.<\/jats:p>","DOI":"10.3390\/vaccines9091004","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T21:36:58Z","timestamp":1631223418000},"page":"1004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Current Progress in the Development of Zika Virus Vaccines"],"prefix":"10.3390","volume":"9","author":[{"given":"Kehui","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-8197","authenticated-orcid":false,"given":"Kutty Selva","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8283-7135","authenticated-orcid":false,"given":"Shibo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology (MOE\/NHC\/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-1453","authenticated-orcid":false,"given":"Naru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biotechadv.2017.09.004","article-title":"Zika virus structural biology and progress in vaccine development","volume":"36","author":"Lin","year":"2018","journal-title":"Biotechnol. 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