{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:04:37Z","timestamp":1794287077190,"version":"4.9.0"},"reference-count":21,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>To protect against COVID-19, SARS-CoV-2 vaccines have been widely used. Besides anaphylaxis, some less severe adverse effects may occur at higher frequencies. It remains unclear whether present or past histories of allergic diseases exert effects on local and systemic reactions. We conducted a questionnaire survey among workers in our hospital. We analyzed the adverse effects occurring after the first and second doses of the Pfizer\u2013BioNTech vaccine in 955 subjects. The presence or absence of local injection reactions and systemic reactions (headache, fatigability, fever, muscle pain, and joint pain) was questioned. The intensities of these reactions were graded on a scale of 0\u20134 (except fever) or 0\u20132 (fever). The allergic diseases that we focused on were bronchial asthma, atopic dermatitis, food allergy, pollinosis, and hand eczema. For the systemic reactions, fatigability after the first dose tended to be more severe in the bronchial asthma than in the non-allergic group. Headache, joint pain, and fever tended to be more severe in the food allergy than in the non-allergic group after the second dose. For the local skin reactions, atopic dermatitis subjects tended to show rather less severe local skin reactions after the second dose. The results contribute to the guidelines for the care of individuals with different allergy histories, so that they may safely receive their vaccine.<\/jats:p>","DOI":"10.3390\/vaccines9121421","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T02:56:14Z","timestamp":1638413774000},"page":"1421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Questionnaire Survey of Possible Association of Allergic Diseases with Adverse Reactions to SARS-CoV-2 Vaccination"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-8394","authenticated-orcid":false,"given":"Hiroki","family":"Morimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology & Skin Oncology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-5755","authenticated-orcid":false,"given":"Satoshi","family":"Hayano","sequence":"additional","affiliation":[{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Department of Pediatrics, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-2125","authenticated-orcid":false,"given":"Naoya","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Department of Respiratory Internal Medicine, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Skin Oncology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Usui","sequence":"additional","affiliation":[{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Department of Otolaryngology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Usami","sequence":"additional","affiliation":[{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Department of Ophthalmology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ohse","sequence":"additional","affiliation":[{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Department of General Practice, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Skin Oncology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-6919","authenticated-orcid":false,"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Skin Oncology, Chutoen General Medical Center, Kakegawa 436-0040, Japan"},{"name":"Allergic Disease Research Center, Chutoen General Medical Center, Kakegawa 436-0040, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jaip.2020.12.047","article-title":"mRNA vaccines to prevent COVID-19 disease and reported allergic reactions: Current evidence and suggested approach","volume":"9","author":"Banerji","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.alit.2021.04.003","article-title":"Allergy to COVID-19 vaccines: A current update","volume":"70","author":"Cabanillas","year":"2021","journal-title":"Allergol. Int."},{"key":"ref_6","first-page":"1663","article-title":"COVID-19 vaccines: Comparison of biological, pharmacological characteristics and adverse effects of Pfizer\/BioNTech and Moderna Vaccines","volume":"25","author":"Meo","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.15585\/mmwr.mm7008e3","article-title":"First month of COVID-19 vaccine safety monitoring\u2014United States, 14 December 2020\u201313 January 2021","volume":"70","author":"Gee","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Caminati, M., Guarnieri, G., Batani, V., Scarpieri, E., Finocchiaro, A., Chieco-Bianchi, F., Senna, G., and Vianello, A. (2021). COVID-19 vaccination in patients with severe asthma on biologic treatment: Safety, tolerability, and impact on disease control. Vaccines, 9.","DOI":"10.3390\/vaccines9080853"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fimmu.2020.00513","article-title":"Virus-induced T cell-mediated heterologous immunity and vaccine development","volume":"11","author":"Balz","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/all.14426","article-title":"Is asthma protective against COVID-19?","volume":"76","author":"Carli","year":"2021","journal-title":"Allergy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaci.2020.06.001","article-title":"Association of asthma and its genetic predisposition with the risk of severe COVID-19","volume":"146","author":"Zhu","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1038\/s41598-021-84320-8","article-title":"Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses","volume":"11","author":"Balz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jaci.2017.07.025","article-title":"Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness","volume":"140","author":"Edwards","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jaci.2020.05.013","article-title":"ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19","volume":"146","author":"Bradding","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaci.2020.04.009","article-title":"Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2","volume":"146","author":"Jackson","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jaci.2021.01.006","article-title":"Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies","volume":"147","author":"Patrick","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cia2.12033","article-title":"Atopic dermatitis as Th2 disease revisited","volume":"1","author":"Tokura","year":"2018","journal-title":"J. Cutan. Immunol. Allergy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12016-020-08797-3","article-title":"COVID-19 and asthma: Reflection during the pandemic","volume":"59","author":"Liu","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.alit.2015.05.004","article-title":"Hierarchy and molecular properties of house dust mite allergens","volume":"64","author":"Thomas","year":"2015","journal-title":"Allergol. Int."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/9\/12\/1421\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:38:25Z","timestamp":1760168305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/9\/12\/1421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["vaccines9121421"],"URL":"https:\/\/doi.org\/10.3390\/vaccines9121421","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}