{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:34:01Z","timestamp":1770226441732,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Choroid plexus tumors are commonly described as intraventricular mass lesions and account for 7\u201310% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and cognitive deficits. On magnetic resonance imaging, a subdural fluid accumulation (SFA) overlying and compressing the left parietotemporal lobe as well as multifocal changes consisting of cyst-like lesions, supposed intra-axial brain lesions and mild, multifocal meningeal thickening and generalized contrast enhancement were identified. Cerebrospinal fluid (CSF) analysis showed a mononuclear pleocytosis with negative results for infectious agents. The dog was treated with prednisolone followed by burr hole craniotomy with puncture of the SFA, which macroscopically appeared to be CSF-like fluid. After initial improvement, the dog deteriorated despite continuation of prednisolone and cytarabine therapy and was euthanized four weeks after surgery. Histopathology was consistent with a disseminated, neuroinvasive choroid plexus carcinoma (CPC) that involved the entire neuroaxis including the meninges of the brain and spinal cord. Immunohistochemical examination showed a strong Kir7.1 and a heterogenous cytokeratin-immunoreactivity in neoplastic cells. In conclusion, a CPC should be considered as a possible cause of a SFA even in the absence of an intraventricular mass lesion.<\/jats:p>","DOI":"10.3390\/vetsci10010024","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:18:18Z","timestamp":1672370298000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog"],"prefix":"10.3390","volume":"10","author":[{"given":"Nina","family":"Schneider","sequence":"first","affiliation":[{"name":"Small Animal Clinic Oberhaching, Bajuwarenring 10, 82041 Oberhaching, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Blutke","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, Veterin\u00e4rstr. 13, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Matiasek","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, Veterin\u00e4rstr. 13, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Parzefall","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Oberhaching, Bajuwarenring 10, 82041 Oberhaching, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1939-1676.2006.tb02913.x","article-title":"Canine Intracranial Primary Neoplasia: 173 Cases (1986\u20132003)","volume":"20","author":"Snyder","year":"2006","journal-title":"J. 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