{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:42:26Z","timestamp":1793695346545,"version":"4.5.1"},"reference-count":247,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T00:00:00Z","timestamp":1673654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry for Education and Research (BMBF)","award":["01DH21010A"],"award-info":[{"award-number":["01DH21010A"]}]},{"name":"German Federal Ministry for Education and Research (BMBF)","award":["01DH21010B"],"award-info":[{"award-number":["01DH21010B"]}]},{"name":"German Federal Ministry for Education and Research (BMBF)","award":["01DH21010C"],"award-info":[{"award-number":["01DH21010C"]}]},{"name":"German Federal Ministry for Education and Research (BMBF)","award":["031B0823D"],"award-info":[{"award-number":["031B0823D"]}]},{"name":"Ma\u00dfgeschneiderte Inhaltsstoffe 2","award":["01DH21010A"],"award-info":[{"award-number":["01DH21010A"]}]},{"name":"Ma\u00dfgeschneiderte Inhaltsstoffe 2","award":["01DH21010B"],"award-info":[{"award-number":["01DH21010B"]}]},{"name":"Ma\u00dfgeschneiderte Inhaltsstoffe 2","award":["01DH21010C"],"award-info":[{"award-number":["01DH21010C"]}]},{"name":"Ma\u00dfgeschneiderte Inhaltsstoffe 2","award":["031B0823D"],"award-info":[{"award-number":["031B0823D"]}]},{"name":"Hans-Fischer-Gesellschaft","award":["01DH21010A"],"award-info":[{"award-number":["01DH21010A"]}],"id":[{"id":"https:\/\/ror.org\/021fnc616","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hans-Fischer-Gesellschaft","award":["01DH21010B"],"award-info":[{"award-number":["01DH21010B"]}],"id":[{"id":"https:\/\/ror.org\/021fnc616","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hans-Fischer-Gesellschaft","award":["01DH21010C"],"award-info":[{"award-number":["01DH21010C"]}],"id":[{"id":"https:\/\/ror.org\/021fnc616","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hans-Fischer-Gesellschaft","award":["031B0823D"],"award-info":[{"award-number":["031B0823D"]}],"id":[{"id":"https:\/\/ror.org\/021fnc616","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Chronic stress is recognized as a secret killer in poultry. It is associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative stress reactions that damage the barrier function of the cells lining the gut wall. Poultry, especially the genetically selected broiler breeds, frequently suffer from these chronic stress symptoms when exposed to multiple stressors in their growing environments. Since oxidative stress reactions and inflammatory damages are multi-stage and long-term processes, overshooting immune reactions and their down-stream effects also negatively affect the animal\u2019s microbiota, and finally impair its performance and commercial value. Means to counteract oxidative stress in poultry and other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids and phenolic compounds, are known to exert anti-inflammatory and antioxidant effects. In this review, firstly, the main stressors in poultry, such as heat stress, mycotoxins, dysbiosis and diets that contain oxidized lipids that trigger oxidative stress and inflammation, are discussed, along with the key transcription factors involved in the related signal transduction pathways. Secondly, the most promising phytogenic substances and their current applications to ameliorate oxidative stress and inflammation in poultry are highlighted.<\/jats:p>","DOI":"10.3390\/vetsci10010055","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:31:32Z","timestamp":1673843492000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-7912","authenticated-orcid":false,"given":"Shereen","family":"Basiouni","sequence":"first","affiliation":[{"name":"Institute of Molecular Physiology, Johannes-Gutenberg University, 55128 Mainz, Germany"},{"name":"Clinical Pathology Department, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-2747","authenticated-orcid":false,"given":"Guillermo","family":"Tellez-Isaias","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-566X","authenticated-orcid":false,"given":"Juan D.","family":"Latorre","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-716X","authenticated-orcid":false,"given":"Brittany D.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Arkansas Agricultural Experiment Station, Fayetteville, AR 72701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-6366","authenticated-orcid":false,"given":"Victor M.","family":"Petrone-Garcia","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico (UNAM), Cuautitlan Izcalli 58190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham R.","family":"El-Seedi","sequence":"additional","affiliation":[{"name":"Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, SE 751 24 Uppsala, Sweden"},{"name":"International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China"},{"name":"International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing 210024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-2729","authenticated-orcid":false,"given":"Sakine","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Ankara University (AU), 06110 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2947-6737","authenticated-orcid":false,"given":"Amr Abd","family":"El-Wahab","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hanover, Germany"},{"name":"Department of Nutrition and Nutritional Deficiency Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-5709","authenticated-orcid":false,"given":"Christian","family":"Visscher","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"May-Simera","sequence":"additional","affiliation":[{"name":"Institute of Molecular Physiology, Johannes-Gutenberg University, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-8162","authenticated-orcid":false,"given":"Claudia","family":"Huber","sequence":"additional","affiliation":[{"name":"Structural Biochemistry of Membranes, Bavarian NMR Center, Technical University of Munich (TUM), D-85747 Garching, 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