{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:46:18Z","timestamp":1760147178606,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Pyometra is a uterine disease typical of the luteal phase of the estrus cycle. For selected patients, such as breeding subjects, ovariohysterectomy is not a valid resolutive option. Medical treatments involving cloprostenol and aglepristone have been developed for the cats, but they can be ineffective in rare cases. Transcervical drainage and flushing have been described for the dogs, as well as for large wild cats. However, to the author\u2019s knowledge, there are no report of uterine drainage in cats. The present case describes an alternative treatment of pyometra in a 3-year-old Main Coon previously treated with aglepristone. The patient underwent a laparotomy: the uterus was exposed, and a sterile urinary catheter was inserted into each horn, through the wall of the uterus, to allow the drainage of pathological collection and a subsequent lavage with lukewarm sterile saline. Medical treatment with aglepristone and marbofloxacin was associated. After treatment, no recurrence was reported, and the cat had an uneventful pregnancy. Although it is a unique case report, the results presented are promising, as the technique appears to have provided healing and preserved fertility. Further studies are needed to confirm its efficacy in the long-term prevention of recurrence.<\/jats:p>","DOI":"10.3390\/vetsci10010060","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:31:32Z","timestamp":1673843492000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of a Recurrent Pyometra by Surgical Uterine Drainage in a Main Coon Cat"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-9657","authenticated-orcid":false,"given":"Gianluca","family":"Martini","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Borghesiana, 00133 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-4933","authenticated-orcid":false,"given":"Roberta","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Parrillo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2283-6146","authenticated-orcid":false,"given":"Augusto","family":"Carluccio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Piano d\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-8503","authenticated-orcid":false,"given":"Maria Carmela","family":"Pisu","sequence":"additional","affiliation":[{"name":"VRC\u2014Centro di Referenza Veterinario, 10138 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.theriogenology.2014.03.007","article-title":"Incidence of pyometra in Swedish insured cats","volume":"82","author":"Hagman","year":"2014","journal-title":"Theriogenology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/1098612X15623114","article-title":"Pyometra in the queen: To spay or not to spay?","volume":"18","author":"Hollinshead","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Melo, R.T., Oliveira, R.P., Silva, B.F., Monteiro, G.P., Saut, J.P.E., Costa, L.R., Dias, S.D.C., and Rossi, D.A. (2022). Phylogeny and Virulence Factors of Escherichia coli Isolated from Dogs with Pyometra. Vet. Sci., 9.","DOI":"10.3390\/vetsci9040158"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/00480169.1980.34714","article-title":"Treatment of feline pyometra with dinoprost","volume":"28","author":"Wiessing","year":"1980","journal-title":"N. Z. Vet. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cvsm.2022.01.004","article-title":"Pyometra in Small Animals 2.0","volume":"52","author":"Hagman","year":"2022","journal-title":"Vet. Clin. Small Anim. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/01652176.2002.9695198","article-title":"Cystic endometrial hyperplasia-pyometra complex in cats. A review","volume":"27","author":"Agudelo","year":"2005","journal-title":"Vet. Q."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jfms.2008.09.006","article-title":"Follow-up examinations after medical treatment of pyometra in cats with the progesterone-antagonist aglepristone","volume":"11","author":"Nak","year":"2009","journal-title":"J. Feline Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S0093-691X(01)00498-8","article-title":"Cystic endometrial hyperplasia-pyometra complex in the bitch: Should the two entities be disconnected?","volume":"55","author":"Ducatelle","year":"2001","journal-title":"Theriogenology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.21608\/jcvr.2020.90228","article-title":"Pyometra in Cats: Medical versus Surgical Treatment","volume":"2","author":"Misk","year":"2020","journal-title":"J. Curr. Vet. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.theriogenology.2015.10.010","article-title":"Aglepristone: A review on its clinical use in animals","volume":"85","author":"Gogny","year":"2016","journal-title":"Theriogenology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1098612X13498248","article-title":"Cloprostenol treatment of feline open-cervix pyometra","volume":"16","author":"Stornelli","year":"2014","journal-title":"J. Feline Med. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Attard, S., Bucci, R., Parrillo, S., and Pisu, M.C. (2022). Effectiveness of a Modified Administration Protocol for the Medical Treatment of Feline Pyometra. Vet. Sci., 9.","DOI":"10.3390\/vetsci9100517"},{"key":"ref_13","unstructured":"Aglepristone (2022, August 22). Scientific Update 2010. Virbac. Available online: https:\/\/es.virbac.com\/files\/live\/sites\/virbac-es\/files\/Elementos%20p%C3%A1ginas\/amvac\/Archivos\/Aglepristone%20Scientific%20update.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/rda.12302","article-title":"Medical treatment for pyometra in dogs","volume":"49","author":"Fieni","year":"2014","journal-title":"Reprod. Domest. Anim."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.theriogenology.2014.08.011","article-title":"A retrospective study of bitches with pyometra, medically treated with aglepristone","volume":"82","author":"Ros","year":"2014","journal-title":"Theriogenology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.4142\/jvs.2019.20.e39","article-title":"Fertility outcome after medically treated pyometra in dogs","volume":"20","author":"Melandri","year":"2019","journal-title":"J. Vet. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1556\/avet.47.1999.1.10","article-title":"Intravaginal prostaglandin f 2\u03b1 for the treatment of metritis and pyometra in the bitch","volume":"47","author":"Gabor","year":"1999","journal-title":"Acta Vet. Hung."},{"key":"ref_18","first-page":"72","article-title":"Intra-uterine Drainage for Treatment of Pyometra in the Bitch","volume":"30","author":"Funkquist","year":"1983","journal-title":"Zent. Vet. Reihe A"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1748-5827.1987.tb05988.x","article-title":"Uterine drainage in the bitch for treatment of pyometra refractory to prostaglandin F2\u03b1","volume":"28","author":"Lagerstedt","year":"1987","journal-title":"J. Small Anim. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1439-0442.1987.tb00260.x","article-title":"Uterine cannulation in the bitch","volume":"34","author":"Lagerstedt","year":"1987","journal-title":"J. Vet. Med. Ser. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1556\/AVet.53.2005.2.10","article-title":"Use of aglepristone and aglepristone+ intrauterine antibiotic for the treatment of pyometra in bitches","volume":"53","author":"Pancarci","year":"2005","journal-title":"Acta Vet. Hung."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4102\/jsava.v81i3.143","article-title":"Surgical uterine drainage and lavage as treatment for canine pyometra: Clinical communication","volume":"81","year":"2010","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.theriogenology.2006.02.018","article-title":"A non-surgical uterine lavage technique in large cats intended for treatment of uterine infection-induced infertility","volume":"66","author":"Hildebrandt","year":"2006","journal-title":"Theriogenology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/avj.12146","article-title":"Vaginal cytology after induction of ovulation in the queen: Comparison of postoestrus and dioestrus","volume":"92","author":"Kanca","year":"2014","journal-title":"Aust. Vet. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.theriogenology.2011.06.002","article-title":"Follicular growth monitoring in the female cat during estrus","volume":"76","author":"Malandain","year":"2011","journal-title":"Theriogenology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.theriogenology.2008.05.040","article-title":"The diagnosis and treatment of endometritis in the mare: Yesterday and today","volume":"70","author":"Liu","year":"2008","journal-title":"Theriogenology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.theriogenology.2005.05.020","article-title":"Transcervical artificial insemination in the cat","volume":"64","author":"Zambelli","year":"2005","journal-title":"Theriogenology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/rda.12442","article-title":"Endoscopic transcervical catheterization in the domestic cat","volume":"50","author":"Zambelli","year":"2015","journal-title":"Reprod. Domest. Anim."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.theriogenology.2006.01.053","article-title":"Cervical patency during non-ovulatory and ovulatory estrus cycles in domestic cats","volume":"66","author":"Chatdarong","year":"2006","journal-title":"Theriogenology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1292\/jvms.62.1247","article-title":"Unilateral intrauterine horn insemination of frozen semen in cats","volume":"62","author":"Tsutsui","year":"2000","journal-title":"J. Vet. Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.theriogenology.2005.05.034","article-title":"Endometritis in the mare: A diagnostic study comparing cultures from swab and biopsy","volume":"64","author":"Nielsen","year":"2005","journal-title":"Theriogenology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.21836\/PEM19970516","article-title":"Uterine lavage with saline in mares as treatment for endometritis","volume":"13","author":"Mattos","year":"1997","journal-title":"Pferdeheilkunde"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/1\/60\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:06:28Z","timestamp":1760119588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/1\/60"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,15]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["vetsci10010060"],"URL":"https:\/\/doi.org\/10.3390\/vetsci10010060","relation":{},"ISSN":["2306-7381"],"issn-type":[{"type":"electronic","value":"2306-7381"}],"subject":[],"published":{"date-parts":[[2023,1,15]]}}}