{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:42Z","timestamp":1787030142556,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Intracranial granular cell tumours (GCT) are uncommon neoplasms of uncertain cellular origin that are rarely reported in dogs. This case series describes three aged dogs that presented with neurological signs in which magnetic resonance (MR) imaging revealed plaquelike extra-axial lesions that were hypointense on T2-weighted (T2w) images. The surgical biopsy of the lesions and necropsies were followed by histochemical characterisation with periodic acid\u2013Schiff (PAS) staining and immunohistochemistry with ubiquitin, S-100, and SOX-10 to elucidate the cellular origin. The immunohistochemical study indicated that these intracranial GCTs were not of Schwann cell origin. In conclusion, GCTs should be considered a differential diagnosis of intracranial, extra-axial hypointense brain lesions on T2w MR images.<\/jats:p>","DOI":"10.3390\/vetsci10020134","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:37:07Z","timestamp":1675906627000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intracranial Granular Cell Tumours in Three Dogs: Atypical Magnetic Resonance Imaging Features and Immunohistochemical Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-7026","authenticated-orcid":false,"given":"Cl\u00e0udia","family":"Mayor","sequence":"first","affiliation":[{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Verd\u00e9s","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7203-0634","authenticated-orcid":false,"given":"Jaume","family":"Alomar","sequence":"additional","affiliation":[{"name":"Servei de Diagn\u00f2stic de Patologia Veterin\u00e0ria, Departament de Sanitat i Anatomia d\u2019Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Novellas","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-7941","authenticated-orcid":false,"given":"Mart\u00ed","family":"Pumarola","sequence":"additional","affiliation":[{"name":"Unitat de Patologia Murina i Comparada, Departament de Sanitat i Anatomia d\u2019Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f2nia","family":"A\u00f1or","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Departament de Medicina i Cirurgia Animals, Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1354\/vp.43-5-797","article-title":"A Cerebral Granular Cell Tumor in a Cat","volume":"43","author":"Mandara","year":"2006","journal-title":"Vet. 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