{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:16Z","timestamp":1760147656145,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>A nine year old cross-breed dog was presented with a two week history of ambulatory tetraparesis and proprioceptive ataxia affecting all four limbs. Meningomyelitis of Unknown Origin (MUO) was presumptively diagnosed based on the magnetic resonance imaging (MRI) findings and cerebrospinal fluid (CSF) analysis. The dog received a tapering dose of glucocorticoids and cyclosporine, showing significant improvement and the stabilization of the clinical signs for seven months. After this period, the dog showed an acute clinical deterioration and a follow-up MRI revealed new multiple lesions affecting different spinal nerve roots along the cervicothoracic spinal cord. Following euthanasia, a final diagnose of multiple malignant peripheral nerve sheath tumors (MPNSTs) was made based on the histopathological examination. MPNSTs can affect the cranial nerves, spinal nerves or the associated nerve roots at any location and can lead to secondary spinal cord compression. The aim of the present case report is to describe the clinical presentation and atypical MRI findings of a dog with histologically confirmed multiple MPNSTs. According to the reviewed literature, this is the first reported case of simultaneous MPNSTs in the cervicothoracic spinal cord of a dog.<\/jats:p>","DOI":"10.3390\/vetsci10020170","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T01:39:28Z","timestamp":1676943568000},"page":"170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic Multifocal Malignant Peripheral Nerve Sheath Tumour in the Cervicothoracic Spinal Cord of a Dog Initially Mimicking Meningomyelitis"],"prefix":"10.3390","volume":"10","author":[{"given":"Javier","family":"Espinosa","sequence":"first","affiliation":[{"name":"Neurology and Neurosurgery Service of Centro Cl\u00ednico Veterinario Indautxu, Alameda de San Mam\u00e9s 38, 48010 Bilbao, Spain"},{"name":"Neurology and Neurosurgery Service, Pride Referrals, Derby DE248 HX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-0322","authenticated-orcid":false,"given":"Mar\u00eda","family":"Ortega","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Service of Centro Cl\u00ednico Veterinario Indautxu, Alameda de San Mam\u00e9s 38, 48010 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-7941","authenticated-orcid":false,"given":"Mart\u00ed","family":"Pumarola","sequence":"additional","affiliation":[{"name":"Mouse and Comparative Pathology Unit, Department of Animal Medicine and Surgery, Veterinary Faculty, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Campus UAB, Universitat Aut\u00f2noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Fraga","sequence":"additional","affiliation":[{"name":"Fraga Diagnostic Espa\u00f1a, S.L., Mijas Costa, 29649 Malaga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-6576","authenticated-orcid":false,"given":"Laura","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Service of Centro Cl\u00ednico Veterinario Indautxu, Alameda de San Mam\u00e9s 38, 48010 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4314\/ovj.v9i1.9","article-title":"Central Nervous System Metastasis of an Intradural Malignant Peripheral Nerve Sheath Tumour in a Dog","volume":"9","author":"Poli","year":"2019","journal-title":"Open Vet. 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