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Methods: Daily milk yield was recorded and weekly milk samples collected for the first 70 days of lactation from MgB supplemented (MgB, n = 34), and unsupplemented (Control, n = 31) multiparous Holstein-Friesian cows. During a period from week 3 to week 10 postpartum, blood samples were taken and analyzed for various parameters, and ruminant activity was measured. Results: The MgB group yielded 25.2% more milk than the Control during week 1, and had increased milk fat and protein concentrations over a longer duration. Somatic cell counts (SCC) were decreased in the MgB group independent of days in milk. No differences were observed between groups in terms of plasma non-esterified fatty acids, \u03b2-hydroxybutyrate, glucose, or blood iCa levels. The MgB group had lower haptoglobin (Hp) levels during lactation relative to the Control group. Time spent ruminating increased after calving with MgB due to a shorter post calving rumination delay relative to the Control group. Conclusions: Prepartum MgB supplementation improved lactation performance without affecting blood energy analytes. The basis by which MgB also improved rumination activity remains to be determined, as DMI could not be assessed. As MgB lowered SCC and Hp concentrations, it is speculated that MgB may help minimize postpartum inflammatory processes.<\/jats:p>","DOI":"10.3390\/vetsci10040276","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:42:44Z","timestamp":1680673364000},"page":"276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Prepartum Magnesium Butyrate Supplementation on Rumination Time, Milk Yield and Composition, and Blood Parameters in Dairy Cows"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-0664","authenticated-orcid":false,"given":"Hedvig","family":"F\u00e9bel","sequence":"first","affiliation":[{"name":"Institute of Physiology and Nutrition, Kaposv\u00e1r Campus, Hungarian University of Agriculture and Life Sciences, Geszteny\u00e9s \u00fat 1, H-2053 Herceghalom, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0759-633X","authenticated-orcid":false,"given":"Joan","family":"Edwards","sequence":"additional","affiliation":[{"name":"Palital Feed Additives B.V., De Tweede Geerden 11, 5334 LH Velddriel, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-0968","authenticated-orcid":false,"given":"Ferenc","family":"Pajor","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, G\u00f6d\u00f6ll\u0151 Campus, Hungarian University of Agriculture and Life Sciences, P\u00e1ter K\u00e1roly utca 1, H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-3508","authenticated-orcid":false,"given":"Viktor","family":"Jurkovich","sequence":"additional","affiliation":[{"name":"Department of Animal Hygiene, Herd Health and Mobile Clinic, University of Veterinary Medicine, Istv\u00e1n utca 2, H-1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikolt","family":"Bakony","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Veterinary Medicine, Istv\u00e1n utca 2, H-1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, G\u00f6d\u00f6ll\u0151 Campus, Hungarian University of Agriculture and Life Sciences, P\u00e1ter K\u00e1roly utca 1, H-2100 G\u00f6d\u00f6ll\u0151, Hungary"},{"name":"Bona Adventure Ltd., Peres utca 44, H-2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3168\/jds.S0022-0302(06)72198-1","article-title":"Major advances in nutrition: Impact on milk composition","volume":"89","author":"Jenkins","year":"2006","journal-title":"J. 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