{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:33:54Z","timestamp":1773833634383,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Urine test strips are commercially available and can be assessed with semi-automated analyzers or by visual assessment. This study aimed to compare the visual and automated evaluations of dipstick variables in canine urine samples. One hundred and nineteen urine samples were evaluated. Automated analysis was performed on a veterinary urine analyzer URIT-50Vet (URIT Medical Electronic) with UC VET13 Plus strips. Multistix 10 SG dipsticks (Siemens Healthcare GmbH, Erlangen, Germany) were used for visual evaluation, along with a refractometer (Clinical Refractometer Atago T2-Ne, Atago Co., Tokyo, Japan) for urine specific gravity measurements. A linear relationship was observed between the pH measurements (p = 0.2) of the two methods; the Passing\u2013Bablok procedure was valid since neither proportional nor systematic significant errors were observed. Comparing the two methods, the correlation for urine specific gravity was poor (p = 0.01, CI 0.667\u20131.000). Moderate agreement was demonstrated for proteins (\u03ba = 0.431), bilirubin (\u03ba = 0.434) and glucose (\u03ba = 0.450). Agreement was substantial for blood (\u03ba = 0.620) and poor for leukocytes (\u03ba = 0.100). Poor agreement was observed for ketones (\u03ba = \u22120.006). Apart from the pH analysis, visual and automated dipstick urinalyses should not be used interchangeably. Multiple urine samples obtained from the same dog during the day should be evaluated using the same method to overcome erroneous results.<\/jats:p>","DOI":"10.3390\/vetsci10040284","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T05:59:33Z","timestamp":1681106373000},"page":"284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Evaluation between Visual and Automated Dipstick Urinalyses in Dogs"],"prefix":"10.3390","volume":"10","author":[{"given":"Erasmia D.","family":"Smyroglou","sequence":"first","affiliation":[{"name":"Diagnostic Laboratory, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-2629","authenticated-orcid":false,"given":"Labrini V.","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Trikalon 224, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-4522","authenticated-orcid":false,"given":"Rania D.","family":"Baka","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratory, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-2398","authenticated-orcid":false,"given":"Zoe S.","family":"Polizopoulou","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratory, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bartges, J., and Polzin, D.J. (2011). Nephrology and Urology of Small Animals, Blackwell Publishing Ltd.","DOI":"10.1002\/9781118785546"},{"key":"ref_2","unstructured":"Osborne, C.A., and Stevens, J.B. (1999). Urinalysis: A Clinical Guide to Compassionate Patient Care, Bayer Corporation and Bayer AG."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Elliott, J., Grauer, G.F., and Westropp, J.L. (2017). BSAVA Manual of Canine and Feline Nephrology and Urology, British Small Animal Veterinary Association.","DOI":"10.22233\/20412495.1117.12"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.14202\/vetworld.2020.2133-2141","article-title":"Urinalysis in Dog and Cat: A Review","volume":"13","author":"Yadav","year":"2020","journal-title":"Vet. World"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2460\/javma.2003.222.176","article-title":"Effects of Storage Time and Temperature on PH, Specific Gravity, and Crystal Formation in Urine Samples from Dogs and Cats","volume":"222","author":"Albasan","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_6","unstructured":"Vaden, S.L., Knoll, J.S., Smith, F.W.K., and Tilley, L.P. (2009). Blackwell\u2019s Five-Minute Veterinary Consult: Laboratory Tests and Diagnostic Procedures, Canine and Feline, Wiley-Blackwell."},{"key":"ref_7","unstructured":"Bellwood, B.A.-C. (2014). Veterinary Technician\u2019s Handbook of Laboratory Procedures, John Wiley & Sons, Inc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cvsm.2018.10.005","article-title":"Importance of Urinalysis","volume":"49","author":"Piech","year":"2019","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"ref_9","first-page":"2897","article-title":"Correlation of a Quantitative and a Semi-Quantitative Method for Proteinuria Detection in Chronic Kidney Disease in Dogs","volume":"72","author":"Baka","year":"2021","journal-title":"J. Hell. Vet. Med. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1309\/15R1-46YG-CV95-C36K","article-title":"Technology behind Diagnostic Reagent Strips","volume":"31","author":"Pugia","year":"2000","journal-title":"Lab. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/vr.104841","article-title":"Urine Dipstick Precision with Standard Visual and Automated Methods within a Small Animal Teaching Hospital","volume":"183","author":"Ferreira","year":"2018","journal-title":"Vet. Rec."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3343\/alm.2019.39.1.15","article-title":"Progress in Automated Urinalysis","volume":"39","author":"Oyaert","year":"2018","journal-title":"Ann. Lab. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.rvsc.2013.01.002","article-title":"Automated and Visual Analysis of Commercial Urinary Dipsticks in Dogs, Cats and Cattle","volume":"94","author":"Defontis","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/vcp.12899","article-title":"Basal Glucose Excretion in Dogs: The Impact of Feeding, Obesity, Sex, and Age","volume":"49","author":"Zeugswetter","year":"2020","journal-title":"Vet. Clin. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.22870","article-title":"Semiquantitative, Fully Automated Urine Test Strip Analysis","volume":"33","author":"Oyaert","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/vcp.12594","article-title":"Evaluation of the Analytical Variability of Dipstick Protein Pads in Canine Urine","volume":"47","author":"Giraldi","year":"2018","journal-title":"Vet. Clin. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Van Delft, S., Goedhart, A., Spigt, M., Van Pinxteren, B., De Wit, N., and Hopstaken, R. (2016). Prospective, Observational Study Comparing Automated and Visual Point-of-Care Urinalysis in General Practice. BMJ Open, 6.","DOI":"10.1136\/bmjopen-2016-011230"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.preghy.2017.01.005","article-title":"Visual or Automated Dipstick Testing for Proteinuria in Pregnancy?","volume":"7","author":"Correa","year":"2017","journal-title":"Pregnancy Hypertens"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/clinchem\/23.12.2242","article-title":"Semi-Automated vs. Visual Reading of Urinalysis Dipsticks","volume":"23","author":"Peele","year":"1977","journal-title":"Clin. Chem."},{"key":"ref_20","unstructured":"Villiers, E., and Risti\u0107, J. (2016). BSAVA Manual of Canine and Feline Clinical Pathology, British Small Animal Veterinary Association."},{"key":"ref_21","unstructured":"Villiers, E., and Risti\u0107, J. (2016). BSAVA Manual of Canine and Feline Clinical Pathology, British Small Animal Veterinary Association."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Elliott, J., Grauer, G.F., and Westropp, J.L. (2017). BSAVA Manual of Canine and Feline Nephrology and Urology, British Small Animal Veterinary Association.","DOI":"10.22233\/20412495.1117.12"},{"key":"ref_23","unstructured":"Chew, D.J., DiBartola, S.P., and Schenck, P.A. (2011). Canine and Feline Nephrology and Urology, Elsevier."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/vcp.12892","article-title":"Comparison of Canine Urine Specific Gravity Measurements between Various Refractometers in a Clinical Setting","volume":"49","author":"Boustead","year":"2020","journal-title":"Vet. Clin. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/vcp.12730","article-title":"Evaluation of the Effect of Urine Dip vs Urine Drip on Multi-Test Strip Results","volume":"48","author":"Boag","year":"2019","journal-title":"Vet. Clin. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1162\/coli.07-034-R2","article-title":"Inter-Coder Agreement for Computational Linguistics","volume":"34","author":"Artstein","year":"2008","journal-title":"Comput. Linguist."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.rvsc.2008.02.003","article-title":"Evaluation the Clinitek StatusTM Automated Dipstick Analysis Device for Semiquantitative Testing of Canine Urine","volume":"85","author":"Bauer","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rizzi, T.E., Valenciano, A., Bowles, M., Cowell, R., Tyler, R., and DeNicola, D.B. (2017). Atlas of Canine and Feline Urinalysis, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781119365693"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cvsm.2015.02.001","article-title":"Urinalysis","volume":"45","author":"Callens","year":"2015","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/ijpvm.IJPVM_353_17","article-title":"How Sensitive Are Dipstick Urinalysis and Microscopy in Making Diagnosis of Urinary Tract Infection in Children?","volume":"10","author":"Maduemem","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_31","first-page":"108","article-title":"Comparison of Urine Dipstick Test with Conventional Urine Culture in Diagnosis of Urinary Tract Infection","volume":"25","author":"Najeeb","year":"2015","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_32","first-page":"1","article-title":"Validity of the Urinary Dipstick Test in the Diagnosis of Urinary Tract Infections in Adults","volume":"69","author":"Chernaya","year":"2022","journal-title":"Dan. Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2460\/javma.257.4.391","article-title":"Accuracy of Urine Dipstick Tests and Urine Glucose-to-Creatinine Ratios for Assessment of Glucosuria in Dogs and Cats","volume":"257","author":"Aldridge","year":"2020","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.5326\/JAAHA-MS-6128","article-title":"Assessment of a Veterinary Dipstick for Determination of Urine Protein\/Creatinine Ratio in Canines","volume":"50","author":"Mamone","year":"2014","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_35","first-page":"52","article-title":"Prevalence Of Colour Vision Deficiency Among Medical Students And Health Personnel","volume":"1","author":"Balasundaram","year":"2006","journal-title":"Malaysian Fam. physician Off. J. Acad. Fam. Physicians Malays."},{"key":"ref_36","first-page":"393","article-title":"Doctors and the Assessment of Blood Glucose Testing Sticks: Does Colour Blindness Matter?","volume":"50","author":"Campbell","year":"2000","journal-title":"Br. J. Gen. Pract."},{"key":"ref_37","first-page":"469","article-title":"Colour Vision Deficiency in the Medical Profession","volume":"49","author":"Spalding","year":"1999","journal-title":"Br. J. Gen. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1258\/0004563001899041","article-title":"Urine Dipstick Testing: Comparison of Results Obtained by Visual Reading and with the Bayer CLINITEK 50","volume":"37","author":"Rumley","year":"2000","journal-title":"Ann. Clin. Biochem."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/4\/284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:13:12Z","timestamp":1760123592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/4\/284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["vetsci10040284"],"URL":"https:\/\/doi.org\/10.3390\/vetsci10040284","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}