{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:21:19Z","timestamp":1787509279206,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This retrospective study described the aetiologies of neonatal diarrhoea cases and their associations with histological findings. A total of 106 diarrhoeic neonatal piglets were selected. Cultures, MALDI typings, PCRs and evaluation of intestinal lesions were performed. A total of 51 cases (48.1%) were positive for only one pathogen and 54 (50.9%) were positive for more than one pathogen. Clostridium perfringens type A was the most frequently detected pathogen (61.3%), followed by Enterococcus hirae (43.4%), rotavirus type A (38.7%), rotavirus type C (11.3%) and enterotoxigenic Escherichia coli (3.8%). Only lesions in the small intestine were correlated with detected pathogens. The detection of rotavirus was associated with an increased probability of observing villous atrophy (p &lt; 0.001), crypt hyperplasia (p = 0.01) and leucocyte necrosis in the lamina propria (p = 0.05). The detection of Clostridium perfringens type A was associated with an increased probability of observing bacilli in close proximity to the mucosa (p &lt; 0.001) and a decreased probability of observing epithelial necrosis (p = 0.04). Detection of Enterococcus hirae was associated with an increased probability of observing enteroadherent cocci (p &lt; 0.001). Multivariate regression logistic models revealed that epithelial necrosis was more likely to occur in Enterococcus hirae-positive piglets (p &lt; 0.02) and neutrophilic infiltrate was more likely to occur in Clostridium perfringens type A- and Enterococcus hirae-positive piglets (p = 0.04 and p = 0.02, respectively).<\/jats:p>","DOI":"10.3390\/vetsci10040304","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T10:11:25Z","timestamp":1682071885000},"page":"304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microbiological Findings and Associated Histopathological Lesions in Neonatal Diarrhoea Cases between 2020 and 2022 in a French Veterinary Pig Practice"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-4420","authenticated-orcid":false,"given":"Gwena\u00ebl","family":"Boulbria","sequence":"first","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"},{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4890-8891","authenticated-orcid":false,"given":"Charlotte","family":"Teixeira Costa","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Amenna-Bernard","sequence":"additional","affiliation":[{"name":"LABOCEA, 22440 Ploufragan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-2127","authenticated-orcid":false,"given":"Sophie","family":"Labrut","sequence":"additional","affiliation":[{"name":"LABOCEA, 22440 Ploufragan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Normand","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"},{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9o","family":"Nicolazo","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Chocteau","sequence":"additional","affiliation":[{"name":"CRCI<sup>2<\/sup>NA, INSERM U1307, CNRS UMR6075, Nantes University, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Chevance","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"},{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Jeusselin","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"},{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Brissonnier","sequence":"additional","affiliation":[{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Lebret","sequence":"additional","affiliation":[{"name":"REZOOLUTION Pig Consulting Services, 56920 Noyal-Pontivy, France"},{"name":"PORC.SPECTIVE Swine Vet Practice, 56920 Noyal-Pontivy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105678","DOI":"10.1016\/j.prevetmed.2022.105678","article-title":"A Field Trial on the Effect of Cross-Fostering on Performance, Clinical Health and Antibiotic Usage during the Suckling Period of Pigs","volume":"205","author":"Nielsen","year":"2022","journal-title":"Prev. 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