{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:20:49Z","timestamp":1768342849228,"version":"3.49.0"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Cocaine is one of the most widely used drugs that, due to its molecular properties, causes various behavioral alterations, including sexual behavior. In vivo and in vitro studies conducted mainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has been shown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug alters the formation of the meiotic spindle as well as may obstruct the ovulation mechanism of mature oocytes. The data provided in this review, in addition to reviewing the current literature on the main effects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully provide a basic overview that may help and support further future studies on the molecular interaction of cocaine and its metabolites with germ cells.<\/jats:p>","DOI":"10.3390\/vetsci10080484","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:09:01Z","timestamp":1690333741000},"page":"484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cocaine Effects on Reproductive Behavior and Fertility: An Overview"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-0435","authenticated-orcid":false,"given":"Luigi","family":"Rosati","sequence":"first","affiliation":[{"name":"Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy"},{"name":"Centro Interdipartimentale di Ricerca \u201cAmbiente\u201d (CIRAM), University Federico II, 80134 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Chianese","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-8107","authenticated-orcid":false,"given":"Aldo","family":"Mileo","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4617-8360","authenticated-orcid":false,"given":"Maria","family":"De Falco","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy"},{"name":"Istituto Nazionale Biostrutture e Biosistemi (INBB), 00136 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9044-2280","authenticated-orcid":false,"given":"Anna","family":"Capaldo","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","unstructured":"UNODC (2022). 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