{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:23:39Z","timestamp":1760149419178,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>A 10-year-old, female spayed Labrador Retriever was referred for acute hepatopathy and urinary retention. Blood work from the initial presentation (day 0) revealed a severe, mixed hepatopathy. Over the course of the patient\u2019s hospitalization, the patient developed liver insufficiency. Urine was submitted for toxicological screening and revealed detection of a trace concentration of alpha-amanitin. The patient was treated supportively for alpha-amanitin intoxication and was discharged from the hospital on day 8, with most biochemical parameters being markedly improved. The patient was persistently hyporexic at the time of discharge. On day 15, at a recheck appointment, the patient had lost 2.4 kg and liver enzymology revealed improved values. On day 24, the patient was presented for anorexia and vomiting and had lost another 2.3 kg. Blood work and endocrinological testing at that time were consistent with hypoadrenocorticism. The patient was started on glucocorticoids and mineralocorticoids. At day 106, the patient was doing well clinically while receiving monthly mineralocorticoids and daily glucocorticoids. This case report is the first to describe the chronological association between alpha-amanitin-induced liver dysfunction and the subsequent development of adrenal insufficiency in a dog.<\/jats:p>","DOI":"10.3390\/vetsci10080500","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T11:23:03Z","timestamp":1691061783000},"page":"500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoadrenocorticism in a Dog Following Recovery from Alpha-Amanitin Intoxication"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5183-2462","authenticated-orcid":false,"given":"Emily A.","family":"Cohen","sequence":"first","affiliation":[{"name":"William Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney M.","family":"Moeller","sequence":"additional","affiliation":[{"name":"William Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-1442","authenticated-orcid":false,"given":"Jonathan D.","family":"Dear","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/21501203.2015.1042536","article-title":"A review on the diversity, phylogeography and population genetics of Amanita mushrooms","volume":"6","author":"Zhang","year":"2015","journal-title":"Mycology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19097","DOI":"10.1073\/pnas.0707340104","article-title":"Gene family encoding the major toxins of lethal Amanita mushrooms","volume":"104","author":"Hallen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2460\/javma.258.5.502","article-title":"Physical examination, serum biochemical, and coagulation abnormalities, treatments, and outcomes for dogs with toxicosis from \u03b1-amanitin\u2013containing mushrooms: 59 cases (2006\u20132019)","volume":"258","author":"Kaae","year":"2021","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.15585\/mmwr.mm6621a1","article-title":"Amanita phalloides Mushroom Poisonings\u2014Northern California, December 2016","volume":"66","author":"Vo","year":"2017","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Walton, J. (2018). 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Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1354\/vp.42-1-52","article-title":"Metastatic Tumors to the Adrenal Glands in Domestic Animals","volume":"42","author":"Labelle","year":"2005","journal-title":"Vet. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1111\/jvim.16531","article-title":"Presumptive nontraumatic adrenal hemorrhage preceding hypoadrenocorticism in a dog","volume":"36","author":"Lee","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/jvim.16564","article-title":"Characterization of clinicopathologic and abdominal ultrasound findings in dogs with glucocorticoid deficient hypoadrenocorticism","volume":"36","author":"Reagan","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/vr.c4235","article-title":"Ultrasonographic evaluation of adrenal glands in dogs with primary hypoadrenocorticism or mimicking diseases","volume":"167","author":"Wenger","year":"2010","journal-title":"Vet. Rec."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archinte.1935.00160230066005","article-title":"Mushroom poisoning (Mycetismus)\u2014Report of four cases","volume":"55","author":"Veer","year":"1935","journal-title":"Arch. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/104063870701900317","article-title":"Diagnosis of Amanita Toxicosis in a Dog with Acute Hepatic Necrosis","volume":"19","author":"Puschner","year":"2007","journal-title":"J. Vet. Diagn. 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