{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:18:04Z","timestamp":1785752284989,"version":"3.56.0"},"reference-count":119,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Canine Research Foundation (PW)","award":["RA399"],"award-info":[{"award-number":["RA399"]}]},{"name":"Australian Canine Research Foundation (PW)","award":["D1350"],"award-info":[{"award-number":["D1350"]}]},{"name":"Australian Canine Research Foundation (PW)","award":["D1312"],"award-info":[{"award-number":["D1312"]}]},{"name":"Border Collie Club of New South Wales","award":["RA399"],"award-info":[{"award-number":["RA399"]}]},{"name":"Border Collie Club of New South Wales","award":["D1350"],"award-info":[{"award-number":["D1350"]}]},{"name":"Border Collie Club of New South Wales","award":["D1312"],"award-info":[{"award-number":["D1312"]}]},{"name":"Mac and Jetty lymphoma research fund","award":["RA399"],"award-info":[{"award-number":["RA399"]}]},{"name":"Mac and Jetty lymphoma research fund","award":["D1350"],"award-info":[{"award-number":["D1350"]}]},{"name":"Mac and Jetty lymphoma research fund","award":["D1312"],"award-info":[{"award-number":["D1312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>There has been considerable interest in studying cancer in dogs and its potential as a model system for humans. One area of research has been the search for genetic risk variants in canine lymphoma, which is amongst the most common canine cancers. Previous studies have focused on a limited number of breeds, but none have included Border Collies. The aims of this study were to identify relationships between Border Collie lymphoma cases through an extensive pedigree investigation and to utilise relationship information to conduct genome-wide association study (GWAS) analyses to identify risk regions associated with lymphoma. The expanded pedigree analysis included 83,000 Border Collies, with 71 identified lymphoma cases. The analysis identified affected close relatives, and a common ancestor was identified for 54 cases. For the genomic study, a GWAS was designed to incorporate lymphoma cases, putative \u201ccarriers\u201d, and controls. A case-control GWAS was also conducted as a comparison. Both analyses showed significant SNPs in regions on chromosomes 18 and 27. Putative top candidate genes from these regions included DLA-79, WNT10B, LMBR1L, KMT2D, and CCNT1.<\/jats:p>","DOI":"10.3390\/vetsci10090581","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T23:17:20Z","timestamp":1695165440000},"page":"581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-6556","authenticated-orcid":false,"given":"Pamela Xing Yi","family":"Soh","sequence":"first","affiliation":[{"name":"School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-1404","authenticated-orcid":false,"given":"Mehar Singh","family":"Khatkar","sequence":"additional","affiliation":[{"name":"Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia"},{"name":"School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-9529","authenticated-orcid":false,"given":"Peter","family":"Williamson","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia"},{"name":"Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1748-5827.2002.tb00066.x","article-title":"Canine neoplasia in the UK: Estimates of incidence rates from a population of insured dogs","volume":"43","author":"Dobson","year":"2002","journal-title":"J. Small Anim. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1476-5810.2003.00025.x","article-title":"Breed incidence of lymphoma in a UK population of insured dogs","volume":"1","author":"Edwards","year":"2003","journal-title":"Vet. Comp. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Comazzi, S., Marelli, S., Cozzi, M., Rizzi, R., Finotello, R., Henriques, J., Pastor, J., Ponce, F., Rohrer-Bley, C., and Rutgen, B.C. (2018). Breed-associated risks for developing canine lymphoma differ among countries: An European canine lymphoma network study. BMC Vet. Res., 14.","DOI":"10.1186\/s12917-018-1557-2"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tvjl.2019.01.003","article-title":"Incidence, characteristics and geographical distributions of canine and human non-Hodgkin\u2019s lymphoma in the Porto region (North West Portugal)","volume":"245","author":"Pinello","year":"2019","journal-title":"Vet. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1158\/0008-5472.CAN-04-4613","article-title":"Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk","volume":"65","author":"Modiano","year":"2005","journal-title":"Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1939-1676.2008.0255.x","article-title":"Genetic and environmental risk indicators in canine non-Hodgkin\u2019s lymphomas: Breed associations and geographic distribution of 608 cases diagnosed throughout France over 1 year","volume":"23","author":"Pastor","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.vetimm.2014.02.016","article-title":"Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: Recent progress and applications","volume":"159","author":"Ito","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/imr.12238","article-title":"Man\u2019s best friend: What can pet dogs teach us about non-Hodgkin\u2019s lymphoma?","volume":"263","author":"Richards","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/sj.bjc.6601275","article-title":"Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes","volume":"89","author":"Thomas","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ferraresso, S., Bresolin, S., Arico, A., Comazzi, S., Gelain, M.E., Riondato, F., Bargelloni, L., Marconato, L., Kronnie, G., and Aresu, L. (2014). Epigenetic silencing of TFPI-2 in canine diffuse large B-cell lymphoma. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092707"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11591","DOI":"10.1038\/s41598-017-11724-w","article-title":"DNA methylation profiling reveals common signatures of tumorigenesis and defines epigenetic prognostic subtypes of canine Diffuse Large B-cell Lymphoma","volume":"7","author":"Ferraresso","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cascione, L., Giudice, L., Ferraresso, S., Marconato, L., Giannuzzi, D., Napoli, S., Bertoni, F., Giugno, R., and Aresu, L. (2019). Long Non-Coding RNAs as Molecular Signatures for Canine B-Cell Lymphoma Characterization. Noncoding RNA, 5.","DOI":"10.3390\/ncrna5030047"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Craig, K.K.L., Wood, G.A., Keller, S.M., Mutsaers, A.J., and Wood, R.D. (2019). MicroRNA profiling in canine multicentric lymphoma. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0226357"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Epiphanio, T.M.F., Fernandes, N., de Oliveira, T.F., Lopes, P.A., Ressio, R.A., Goncalves, S., Scattone, N.V., Tedardi, M.V., Kulikowski, L.D., and Damasceno, J. (2019). Global DNA methylation of peripheral blood leukocytes from dogs bearing multicentric non-Hodgkin lymphomas and healthy dogs: A comparative study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211898"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1101\/gr.194449.115","article-title":"Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background","volume":"25","author":"Elvers","year":"2015","journal-title":"Genome Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/sj.onc.1201489","article-title":"Mutations of the p53 gene in canine lymphoma and evidence for germ line p53 mutations in the dog","volume":"16","author":"Veldhoen","year":"1998","journal-title":"Oncogene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/jsap.13075","article-title":"Geographic distribution and environmental risk factors of lymphoma in dogs under primary-care in the UK","volume":"60","author":"Schofield","year":"2019","journal-title":"J. Small Anim. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.14202\/vetworld.2017.1307-1313","article-title":"Immunocytochemical study of canine lymphomas and its correlation with exposure to tobacco smoke","volume":"10","author":"Pinello","year":"2017","journal-title":"Vet. World"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.envres.2011.12.003","article-title":"Household chemical exposures and the risk of canine malignant lymphoma, a model for human non-Hodgkin\u2019s lymphoma","volume":"112","author":"Barber","year":"2012","journal-title":"Environ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1939-1676.2001.tb02310.x","article-title":"Association between canine malignant lymphoma, living in industrial areas, and use of chemicals by dog owners","volume":"15","author":"Gavazza","year":"2001","journal-title":"J. Vet. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1939-1676.2009.0278.x","article-title":"Association between waste management and cancer in companion animals","volume":"23","author":"Marconato","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., Sarver, A.L., Swofford, R., Frantz, A.M., and Ito, D. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1004922"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1038\/ncomms10460","article-title":"Complex disease and phenotype mapping in the domestic dog","volume":"7","author":"Hayward","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Labadie, J.D., Elvers, I., Feigelson, H.S., Magzamen, S., Yoshimoto, J., Dossey, J., Burnett, R., and Avery, A.C. (2020). Genome-wide association analysis of canine T zone lymphoma identifies link to hypothyroidism and a shared association with mast-cell tumors. BMC Genom., 21.","DOI":"10.1186\/s12864-020-06872-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1016\/j.cell.2022.11.003","article-title":"Domestic dog lineages reveal genetic drivers of behavioral diversification","volume":"185","author":"Dutrow","year":"2022","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/s41598-023-28826-3","article-title":"Analysis of dog breed diversity using a composite selection index","volume":"13","author":"Hsu","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/age.12834","article-title":"A comprehensive biomedical variant catalogue based on whole genome sequences of 582 dogs and eight wolves","volume":"50","author":"Jagannathan","year":"2019","journal-title":"Anim. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mortlock, S.A., Khatkar, M.S., and Williamson, P. (2016). Comparative Analysis of Genome Diversity in Bullmastiff Dogs. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147941"},{"key":"ref_29","first-page":"37","article-title":"Visualization of Genome Diversity in German Shepherd Dogs","volume":"9","author":"Mortlock","year":"2016","journal-title":"Bioinform. Biol. Insights"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1038\/s41598-021-85262-x","article-title":"Evaluation of genetic diversity and management of disease in Border Collie dogs","volume":"11","author":"Soh","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Rosengren Pielberg, G., Sigurdsson, S., Fall, T., Seppala, E.H., Hansen, M.S., and Lawley, C.T. (2011). Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002316"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tvjl.2011.06.020","article-title":"A genealogical survey of Australian registered dog breeds","volume":"189","author":"Shariflou","year":"2011","journal-title":"Vet. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00335-011-9387-6","article-title":"Genomic analyses of modern dog breeds","volume":"23","author":"Parker","year":"2012","journal-title":"Mamm. Genome"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.celrep.2017.03.079","article-title":"Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development","volume":"19","author":"Parker","year":"2017","journal-title":"Cell Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"H\u00e9dan, B., Cadieu, \u00c9., Rimbault, M., Vaysse, A., Dufaure de Citres, C., Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., and Derrien, T. (2021). Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009395"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1111\/jvim.15306","article-title":"Demographic risk factors for lymphoma in Australian dogs: 6201 cases","volume":"32","author":"Bennett","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/avj.12780","article-title":"Lymphoma in Australian Border Collies: Survey results and pedigree analyses","volume":"97","author":"Cheng","year":"2019","journal-title":"Aust. Vet. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000363105","article-title":"The kinship2 R package for pedigree data","volume":"78","author":"Sinnwell","year":"2014","journal-title":"Hum. Hered."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/bioinformatics\/btw019","article-title":"FamAgg: An R package to evaluate familial aggregation of traits in large pedigrees","volume":"32","author":"Rainer","year":"2016","journal-title":"Bioinformatics"},{"key":"ref_40","unstructured":"Coster, A.J.R. (2020, January 08). Pedigree: Pedigree Functions. R Package, Version 1.4. 2013, Volume 1. Available online: https:\/\/cran.r-project.org\/web\/packages\/pedigree\/index.html."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ajhg.2018.07.015","article-title":"A One-Penny Imputed Genome from Next-Generation Reference Panels","volume":"103","author":"Browning","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/jbg.12203","article-title":"Half of 23 Belgian dog breeds has a compromised genetic diversity, as revealed by genealogical and molecular data analysis","volume":"133","author":"Wijnrocx","year":"2016","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Bennett, P., Williamson, P., and Taylor, R. (2023). Review of Canine Lymphoma Treated with Chemotherapy-Outcomes and Prognostic Factors. Vet. Sci., 10.","DOI":"10.3390\/vetsci10050342"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/vco.12058","article-title":"Levels of evidence in canine oncology trials--a case in point","volume":"11","author":"Vail","year":"2013","journal-title":"Vet. Comp. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yexmp.2018.11.008","article-title":"Molecular and cellular genetics of non-Hodgkin lymphoma: Diagnostic and prognostic implications","volume":"106","author":"Pratap","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"731","DOI":"10.21105\/joss.00731","article-title":"qqman: An R package for visualizing GWAS results using Q-Q and manhattan plots","volume":"3","author":"Turner","year":"2018","journal-title":"J. Open. Source Softw."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fgene.2020.00260","article-title":"IntAssoPlot: An R Package for Integrated Visualization of Genome-Wide Association Study Results with Gene Structure and Linkage Disequilibrium Matrix","volume":"11","author":"He","year":"2020","journal-title":"Front. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"108145","DOI":"10.1016\/j.celrep.2020.108145","article-title":"Identification of a Core Module for Bone Mineral Density through the Integration of a Co-expression Network and GWAS Data","volume":"32","author":"Sabik","year":"2020","journal-title":"Cell Rep."},{"key":"ref_52","unstructured":"Tenenbaum, D. (2020, January 08). KEGGREST. R Package Version 1.24.1. Available online: https:\/\/bioconductor.riken.jp\/packages\/3.8\/bioc\/manuals\/KEGGREST\/man\/KEGGREST.pdf."},{"key":"ref_53","first-page":"1","article-title":"Viral Causes of Lymphoma: The History of Epstein-Barr Virus and Human T-Lymphotropic Virus 1","volume":"8","author":"Esau","year":"2017","journal-title":"Virol. Res. Treat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3816\/CLM.2006.n.016","article-title":"Cytomegalovirus infection in patients with lymphoma: An important cause of morbidity and mortality","volume":"6","author":"Torres","year":"2006","journal-title":"Clin. Lymphoma Myeloma"},{"key":"ref_55","first-page":"593","article-title":"Association of Human Cytomegalovirus with Hodgkin\u2019s Disease and Non-Hodgkin\u2019s lymphomas","volume":"18","author":"Mehravaran","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_56","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: Predicting amino acid changes that affect protein function","volume":"31","author":"Ng","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-0998.12442","article-title":"netview p: A network visualization tool to unravel complex population structure using genome-wide SNPs","volume":"16","author":"Steinig","year":"2016","journal-title":"Mol. Ecol. Resour."},{"key":"ref_60","unstructured":"Allaire, J.J., Gandrud, C., Russell, K., and Yetman, C. (2020, January 08). networkD3: D3 JavaScript Network Graphs from R. R Package Version 0.4. Available online: https:\/\/cran.r-project.org\/package=networkD3."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajhg.2011.02.002","article-title":"Estimating missing heritability for disease from genome-wide association studies","volume":"88","author":"Lee","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_62","first-page":"e1","article-title":"Breed prevalence of canine lymphoma in South Africa","volume":"89","author":"Hooijberg","year":"2018","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"ref_63","first-page":"909","article-title":"A prospective survey of familial canine lymphosarcoma","volume":"72","author":"Onions","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4102\/jsava.v80i2.180","article-title":"Lymphoma in 3 related Rottweilers from a single household","volume":"80","author":"Lobetti","year":"2009","journal-title":"J. S. Afr. Vet. Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/geno.1998.5359","article-title":"cDNA sequencing and analysis of POV1 (PB39): A novel gene up-regulated in prostate cancer","volume":"51","author":"Cole","year":"1998","journal-title":"Genomics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/jnci\/djt042","article-title":"Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations","volume":"105","author":"Xu","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1158\/0008-5472.CAN-15-0418","article-title":"NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma","volume":"75","author":"Shimozono","year":"2015","journal-title":"Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3892\/or.2017.5982","article-title":"SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway","volume":"38","author":"Liao","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1111\/jcmm.14134","article-title":"SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p","volume":"23","author":"Wu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/21541264.2022.2069995","article-title":"The histone chaperone FACT: A guardian of chromatin structure integrity","volume":"13","author":"Jeronimo","year":"2022","journal-title":"Transcription"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mt.2016.9","article-title":"SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497","volume":"24","author":"Ding","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/jhered\/esg002","article-title":"Molecular Organization of the Canine Major Histocompatibility Complex","volume":"94","author":"Wagner","year":"2003","journal-title":"J. Hered."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1182\/blood-2010-01-266775","article-title":"Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology","volume":"115","author":"Wang","year":"2010","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1080\/10428194.2019.1617858","article-title":"The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population","volume":"60","author":"Zhong","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1046\/j.1365-2141.1998.00631.x","article-title":"Loss of HLA molecules in B lymphomas is associated with an aggressive clinical course","volume":"100","author":"Amiot","year":"1998","journal-title":"Br. J. Haematol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.13308","article-title":"Protein palmitoylation in cancer: Molecular functions and therapeutic potential","volume":"17","author":"Zhou","year":"2023","journal-title":"Mol. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.febslet.2013.03.024","article-title":"Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death","volume":"587","author":"Yamashita","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbamcr.2015.10.008","article-title":"Phosphorylation and isoform use in p120-catenin during development and tumorigenesis","volume":"1863","author":"Hong","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1158\/1078-0432.CCR-10-2320","article-title":"Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer","volume":"17","author":"Noordhuis","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e22055","DOI":"10.1002\/jcla.22055","article-title":"CTNND(1) 755 T>G Promoter Polymorphism and Risk of Pancreatic Carcinoma in Chinese","volume":"31","author":"Wang","year":"2017","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2019). TMEM16F\/Anoctamin 6 in Ferroptotic Cell Death. Cancers, 11.","DOI":"10.3390\/cancers11050625"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41419-018-0373-8","article-title":"Contribution of TMEM16F to pyroptotic cell death","volume":"9","author":"Ousingsawat","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev-biochem-040320-103615","article-title":"The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators","volume":"91","author":"Rim","year":"2022","journal-title":"Annu. Rev. Biochem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1111\/bph.13949","article-title":"Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas","volume":"174","author":"Bryja","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/bs.pmbts.2017.11.002","article-title":"Wnt Signaling in Hematological Malignancies","volume":"153","author":"Grainger","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/onc.2016.183","article-title":"WNT5A: A motility-promoting factor in Hodgkin lymphoma","volume":"36","author":"Linke","year":"2017","journal-title":"Oncogene"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1158\/0008-5472.CAN-18-1069","article-title":"The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer","volume":"79","author":"Fatima","year":"2019","journal-title":"Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"37201","DOI":"10.1038\/srep37201","article-title":"Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia","volume":"6","author":"Lazzaroni","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"eaau0812","DOI":"10.1126\/science.aau0812","article-title":"LMBR1L regulates lymphopoiesis through Wnt\/\u03b2-catenin signaling","volume":"364","author":"Choi","year":"2019","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.1121343109","article-title":"Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing","volume":"109","author":"Lohr","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","first-page":"13043","article-title":"MLL2 protein is a prognostic marker for gastrointestinal diffuse large B-cell lymphoma","volume":"8","author":"Ye","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nm.3943","article-title":"The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development","volume":"21","author":"Boss","year":"2015","journal-title":"Nat. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/ng.3442","article-title":"The mutational landscape of cutaneous T cell lymphoma and S\u00e9zary syndrome","volume":"47","author":"Abate","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"62627","DOI":"10.18632\/oncotarget.11548","article-title":"Recurrent mutations in NF-\u03baB pathway components, KMT2D, and NOTCH1\/2 in ocular adnexal MALT-type marginal zone lymphomas","volume":"7","author":"Johansson","year":"2016","journal-title":"Oncotarget"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.gene.2017.06.056","article-title":"Histone H3 lysine 4 methyltransferase KMT2D","volume":"627","author":"Froimchuk","year":"2017","journal-title":"Gene"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3324\/haematol.2017.182444","article-title":"Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified","volume":"103","author":"Ji","year":"2018","journal-title":"Haematologica"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/path.1588","article-title":"CDK9\/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation","volume":"203","author":"Bellan","year":"2004","journal-title":"J. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jcp.21311","article-title":"Cdk9\/Cyclin T1 complex: A key player during the activation\/differentiation process of normal lymphoid B cells","volume":"215","author":"Leucci","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"\u0160merc, A., Sodja, E., and Legi\u0161a, M. (2011). Posttranslational modification of 6-phosphofructo-1-kinase as an important feature of cancer metabolism. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019645"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41467-019-08759-0","article-title":"MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jb\/mvn040","article-title":"Heparan sulphate biosynthesis and disease","volume":"144","author":"Nadanaka","year":"2008","journal-title":"J. Biochem."},{"key":"ref_105","first-page":"6491","article-title":"EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1\/2 Signaling Pathway in Acute Lymphoblastic Leukemia","volume":"25","author":"Liu","year":"2019","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00064.2017","article-title":"DEPTOR at the Nexus of Cancer, Metabolism, and Immunity","volume":"98","author":"Caron","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-019-0754-1","article-title":"Targeting mTOR for cancer therapy","volume":"12","author":"Hua","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3892\/ijmm.2013.1299","article-title":"Knockdown of DEPTOR induces apoptosis, increases chemosensitivity to doxorubicin and suppresses autophagy in RPMI-8226 human multiple myeloma cells in vitro","volume":"31","author":"Zhang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/01652176.2016.1152633","article-title":"Canine lymphoma: A review","volume":"36","author":"Zandvliet","year":"2016","journal-title":"Vet. Q."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exphem.2020.07.005","article-title":"DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells","volume":"88","year":"2020","journal-title":"Exp. Hematol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1182\/blood-2011-08-370536","article-title":"miR-155 regulates HGAL expression and increases lymphoma cell motility","volume":"119","author":"Dagan","year":"2012","journal-title":"Blood"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Due, H., Svendsen, P., B\u00f8dker, J.S., Schmitz, A., B\u00f8gsted, M., Johnsen, H.E., El-Galaly, T.C., Roug, A.S., and Dybk\u00e6r, K. (2016). miR-155 as a Biomarker in B-Cell Malignancies. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/9513037"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.leukres.2018.05.006","article-title":"Over expression of circulating miR-155 predicts prognosis in diffuse large B-cell lymphoma","volume":"70","author":"Ahmadvand","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12185-015-1847-4","article-title":"Oncogenic microRNA-155 and its target PU.1: An integrative gene expression study in six of the most prevalent lymphomas","volume":"102","author":"Huskova","year":"2015","journal-title":"Int. J. Hematol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cellsig.2015.02.015","article-title":"Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways","volume":"27","author":"Tanaka","year":"2015","journal-title":"Cell Signal."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10495-016-1230-9","article-title":"Sec6\/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells","volume":"21","author":"Tanaka","year":"2016","journal-title":"Apoptosis Int. J. Program. Cell Death"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2016.06.001","article-title":"Functional Implications of the spectrum of BCL2 mutations in Lymphoma","volume":"769","author":"Singh","year":"2016","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/leu.2011.378","article-title":"BCL2 mutations in diffuse large B-cell lymphoma","volume":"26","author":"Schuetz","year":"2012","journal-title":"Leukemia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ng.3766","article-title":"Case-control association mapping by proxy using family history of disease","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/9\/581\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:53:37Z","timestamp":1760129617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/9\/581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":119,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["vetsci10090581"],"URL":"https:\/\/doi.org\/10.3390\/vetsci10090581","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]}}}