{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:59:54Z","timestamp":1790823594391,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Pseudomonas\u00a0aeruginosa is a highly pathogenic bacterium with high pathogenicity, that can cause serious infections in all species and especially in dogs. Treatment of the infection induced by this bacterium can be a challenge considering that some strains have developed resistance to most classes of antimicrobials. The use of bacteriophages to alleviate infections caused by Pseudomonas aeruginosa has demonstrated their potential for both internal and external applications. This study aimed to illustrate the treatment with bacteriophages in bacterially complicated skin lesions that do not respond to antimicrobial therapy.<\/jats:p>","DOI":"10.3390\/vetsci10110642","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T07:35:06Z","timestamp":1699169706000},"page":"642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Bacteriophages Therapy of Interdigital Pyoderma Complicated by Cellulitis with Antibiotic-Resistant Pseudomonas aeruginosa in a Dog\u2014Case Report"],"prefix":"10.3390","volume":"10","author":[{"given":"Mariana","family":"Grecu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-040X","authenticated-orcid":false,"given":"M\u0103d\u0103lina-Elena","family":"Henea","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-0040","authenticated-orcid":false,"given":"Cristina Mihaela","family":"R\u00eembu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina","family":"Simion","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eusebiu-Viorel","family":"\u015eindilar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-9574","authenticated-orcid":false,"given":"Gheorghe","family":"Solcan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine, Ia\u0219i University of Life Sciences \u201cIon Ionescu de la Brad\u201d, 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,5]]},"reference":[{"key":"ref_1","first-page":"7310","article-title":"Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016\/429): Antimicrobial-resistant Pseudomonas aeruginosa in dogs and cats","volume":"20","author":"Nielsen","year":"2022","journal-title":"EFSA J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S1466252319000161","article-title":"Efficacy of experimental phage therapies in livestock","volume":"21","author":"Dec","year":"2020","journal-title":"Anim. Health Res. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1155\/2006\/329465","article-title":"Phage Therapy\u2014Everything Old is New Again","volume":"17","author":"Kropinski","year":"2006","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nrmicro3096","article-title":"Revenge of the phages: Defeating bacterial defences","volume":"11","author":"Samson","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Beschastnov, V.V., Egorikhina, M.N., Tulupov, A.A., Pogodin, I.E., Orlinskaya, N.Y., Antoshina, V.V., Shirokova, I.Y., and Ryabkov, M.G. (2023). Immobilization of Bacteriophages in Ex Tempore Hydrogel for the Treatment of Burn Wound Infection. Gels, 9.","DOI":"10.3390\/gels9080625"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Loponte, R., Pagnini, U., Iovane, G., and Pisanelli, G. (2021). Phage Therapy in Veterinary Medicine. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040421"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Batinovic, S., Wassef, F., Knowler, S.A., Rice, D.T.F., Stanton, C.R., Rose, J., Tucci, J., Nittami, T., Vinh, A., and Drummond, G.R. (2019). Bacteriophages in Natural and Artificial Environments. Pathogens, 8.","DOI":"10.3390\/pathogens8030100"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.17352\/ijvsr.000126","article-title":"Review of bacteriophage and its applications","volume":"8","author":"Gamachu","year":"2022","journal-title":"Int. J. Vet. Sci. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1586\/eri.11.90","article-title":"Bacteriophage Therapy: Potential uses in the control of antibiotic-resistant pathogens","volume":"9","author":"Burrowes","year":"2011","journal-title":"Expert. Rev. Anti-Infect. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rvsc.2018.11.008","article-title":"Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius","volume":"122","author":"Moodley","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/00480169.2018.1491348","article-title":"Bacteriophage Therapy for Management of Bacterial Infections in Veterinary Practice: What Was Once Old Is New Again","volume":"66","author":"Squires","year":"2018","journal-title":"N. Z. Vet. J."},{"key":"ref_12","unstructured":"EUCAST (2023, February 01). Antimicrobial Susceptibility Testing EUCAST Disk Diffusion Method, Version 11 (January 2023). Available online: https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Disk_test_documents\/2023_manuals\/Manual_v_11.0_EUCAST_Disk_Test_2023.pdf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/jam.15284","article-title":"Hypochlorous acid solution is a potent antiviral agent against SARS-CoV-2","volume":"132","author":"Hatanaka","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"ref_14","unstructured":"Miller, W.H., Griffin, C.E., and Campbell, K.L. (2013). Muller & Kirk\u2019s Small Animal Dermatology, Elsevier Mosby."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-3164.2007.00635.x","article-title":"First report of multiresistant, mecA-positive Staphylococcus intermedius in Europe: 12 cases from a veterinary dermatology referral clinic in Germany","volume":"18","author":"Loeffler","year":"2007","journal-title":"Vet. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vetmic.2017.09.015","article-title":"Frequency, antimicrobial susceptibility and clonal distribution of methicillin-resistant Staphylococcus pseudintermedius in canine clinical samples submitted to a veterinary diagnostic laboratory in Italy: A 3-year retrospective investigation","volume":"211","author":"Ventrella","year":"2017","journal-title":"Vet. Microbiol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fvets.2020.00414","article-title":"Geographical Variations in Virulence Factors and Antimicrobial Resistance Amongst Staphylococci Isolated from Dogs From the United Kingdom and Romania","volume":"7","author":"Hritcu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.micinf.2003.08.009","article-title":"Antimicrobial resistance of Pseudomonas aeruginosa biofilms","volume":"5","author":"Drenkard","year":"2003","journal-title":"Microbes Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1348-0421.2011.00416.x","article-title":"Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: Current status of antimicrobial resistance and prevailing resistance mechanisms","volume":"56","author":"Harada","year":"2012","journal-title":"Microbiol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Poole, K. (2011). Pseudomonas aeruginosa: Resistance to the max. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00065"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ferriol-Gonz\u00e1lez, C., and Domingo-Calap, P. (2021). Phage Therapy in Livestock and Companion Animals. Antibiotics, 10.","DOI":"10.3390\/antibiotics10050559"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.vetmic.2010.05.014","article-title":"Topical treatment of Pseudomonas aeruginosa otitis of dogs with a bacteriophage mixture: A before\/after clinical trial","volume":"146","author":"Hawkins","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1292\/jvms.15-0310","article-title":"Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases","volume":"78","author":"Furusawa","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1749-4486.2009.01973.x","article-title":"A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy","volume":"34","author":"Wright","year":"2009","journal-title":"Clin. Otolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ferriol-Gonz\u00e1lez, C., and Domingo-Calap, P. (2020). Phages for Biofilm Removal. Antibiotics, 9.","DOI":"10.3390\/antibiotics9050268"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mib.2017.09.004","article-title":"Phage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections","volume":"39","author":"Pires","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nature11723","article-title":"Bacteriophage genes that inactivate the CRISPR\/Cas bacterial immune system","volume":"493","author":"Pawluk","year":"2013","journal-title":"Nature"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/11\/642\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:17:47Z","timestamp":1760131067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/10\/11\/642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,5]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["vetsci10110642"],"URL":"https:\/\/doi.org\/10.3390\/vetsci10110642","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,5]]}}}