{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:07:27Z","timestamp":1774778847351,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This retrospective cohort study included one hundred fifty-seven medium and large-size dogs with the aim of evaluating the effect of signalment and echocardiographic features on complications, outcomes and left ventricular modifications before and after patent ductus arteriosus (PDA) closure. The patients were divided in two groups based on the heart remodeling after closure: Group A included dogs that had a reduction in the end-systolic volume index (ESVI) after closure compared to the ESVI measured before; Group B included dogs without a reduction in ESVI after closure. Body weight, minimal ductal diameter (MDD) of PDA, end-diastolic volume index and presence of arrhythmias at presentation were significantly higher in Group B compared to Group A. The shortening fraction and ejection fraction after closure were reduced in both groups, but in Group B there was a major reduction, and the mean values indicated a possible systolic dysfunction. Complications during the procedure and death due to cardiac reasons were greater in Group B compared to Group A. In conclusion, a higher body weight, a larger MDD, a more severe heart enlargement or arrhythmias at presentation increased the risk of developing a worsening structural and functional condition after ductal closure, and this can be associated with perioperative complications and cardiac death.<\/jats:p>","DOI":"10.3390\/vetsci10120669","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T03:54:35Z","timestamp":1700798075000},"page":"669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Retrospective Cohort Evaluation of Left Ventricular Remodeling, Perioperative Complications and Outcome in Medium and Large Size Dogs with Patent Ductus Arteriosus after Percutaneous Closure"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-8334","authenticated-orcid":false,"given":"Melissa","family":"Papa","sequence":"first","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Scarpellini","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danitza","family":"Pradelli","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Zanaboni","sequence":"additional","affiliation":[{"name":"Computer Science Department, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy"},{"name":"Data Science Research Center DSRC, Universit\u00e0 degli Studi di Milano, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Mattia","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Boz","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Forti","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Longobardi","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Pasquinelli","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Celeste","family":"Gendusa","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Gamba","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Maria","family":"Bussadori","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Gran Sasso, 20134 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1939-1676.2011.0711.x","article-title":"Retrospective Review of Congenital Heart Disease in 976 Dogs: Congenital Heart Disease in 976 Dogs","volume":"25","author":"Oliveira","year":"2011","journal-title":"J. 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