{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:13Z","timestamp":1760144113629,"version":"build-2065373602"},"reference-count":83,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wildlife Disease Association\u2014Australasia Section Small Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Julia Creek dunnarts are an endangered species of carnivorous marsupials and the focus of multiple conservation strategies involving significant resources such as captive breeding programs. Despite the relevance for conservation, no study to date has focused on evaluating geriatric diseases in dunnarts. This study describes the pathology findings in a group of one wild and thirty-five captive-born, mostly geriatric Julia Creek dunnarts that failed to produce offspring over multiple breeding periods. A total of 20 females and 16 males were submitted for a postmortem examination, with ages ranging from 9 to 42 and 12 to 42 months for females and males, respectively. Of these, 10 had unremarkable findings. The most common condition in females was cystic glandular hyperplasia (n = 8), typical of hormonal dysregulation profiles in senescence, particularly hyperestrogenism. Rarely, cutaneous disease represented by unidentified dermal round cell infiltrates was observed in females (n = 2). Primary reproductive hormonal dysregulation was also suspected in males diagnosed with testicular degeneration, aspermatogenesis and\/or atrophy (n = 3). Cutaneous round cell infiltrates, possibly compatible with epitheliotropic lymphomas, were seen in males (n = 3), and 2\/3 affected males also had concurrent testicular degeneration or atrophy, indicating male sex could be a predictor for lymphoid neoplasia in aged dunnarts, especially in individuals with concurrent testosterone-luteinizing hormone dysregulation as it occurs in gonadectomized animals. The role of an underlying viral etiology is also explored. This study is the first to describe major spontaneous diseases in endangered aged Julia Creek dunnarts, providing an important understanding of senescence and geriatric diseases within a conservation context.<\/jats:p>","DOI":"10.3390\/vetsci11040142","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T05:10:53Z","timestamp":1711084253000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis douglasi, Archer 1979) with Emphasis in Reproductive Pathology"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-361X","authenticated-orcid":false,"given":"Viviana","family":"Gonzalez-Astudillo","sequence":"first","affiliation":[{"name":"School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Schaffer-White","sequence":"additional","affiliation":[{"name":"Independent Veterinary Pathology, 3245 Logan Road, Underwood, Brisbane, QLD 4119, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Noble","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"O\u2019Hara","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Sustainability, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"},{"name":"Biological Resources, The University of Queensland, Brisbane, QLD 4072, Australia"},{"name":"School of Agriculture and Environmental Science, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-2147","authenticated-orcid":false,"given":"Tamsin S.","family":"Barnes","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-7125","authenticated-orcid":false,"given":"Rachel","family":"Allavena","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Benirschke, K. 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