{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:18:19Z","timestamp":1784128699987,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","award":["RGNS 64-020"],"award-info":[{"award-number":["RGNS 64-020"]}],"id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Vascular neoplasms, including hemangiosarcoma (HSA) and hemangioma (HMA), are more common in dogs than other domestic animal species; however, comprehensive laboratory screening tests for early diagnosis are currently limited. The aims of this study were to investigate general signalments, anatomic locations, and clinicopathological abnormalities of dogs diagnosed with vascular neoplasms and to determine the diagnostic significance of these abnormalities. Retrospective data of dogs with HMA, HSA, and healthy dogs were analyzed. Dogs with HMA and HSA were seniors, with mixed breeds being most affected. HMA affected predominantly non-visceral sites, while HSA was more common in visceral sites, particularly the spleen. In multivariate model analyses, the odds of HMA diagnosis were 5.5 times higher in anemic dogs and 33.0 times higher in lymphopenic dogs compared to dogs without the abnormalities. The odds of HSA diagnosis were 42.5 times higher in anemic dogs, 343 times higher in lymphopenic dogs and 92.7 times higher in dogs with hyperfibrinogenemia compared to dogs without the abnormalities. The study suggested that these identified abnormalities were nonspecific and commonly observed in various chronic diseases, and hence their combination with clinical information, such as diagnostic imaging and histopathology, is important to facilitate a more precise diagnosis of canine vascular neoplasms.<\/jats:p>","DOI":"10.3390\/vetsci11050189","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retrospective Study of Clinicopathological Changes and Prediction Model for Canine Vascular Neoplasms"],"prefix":"10.3390","volume":"11","author":[{"given":"Jidapa","family":"Suphonkhan","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chananchida","family":"Klaymongkol","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wijittra","family":"Khomsiri","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jedsada","family":"Wanprom","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saharuetai","family":"Jeamsripong","sequence":"additional","affiliation":[{"name":"Research Unit in Microbial Food Safety and Antimicrobial Resistance, Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisara","family":"Chimnakboon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-969X","authenticated-orcid":false,"given":"Anudep","family":"Rungsipipat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"},{"name":"Center of Excellence for Companion Animal Cancer, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-3287","authenticated-orcid":false,"given":"Araya","family":"Radtanakatikanon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"},{"name":"Center of Excellence for Companion Animal Cancer, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1002\/vetr.585","article-title":"Canine and feline haemangiosarcoma","volume":"189","author":"Griffin","year":"2021","journal-title":"Vet. Rec."},{"key":"ref_2","unstructured":"Vail, D.M., Thamm, D.H., and Liptak, J.M. (2020). Withrow & MacEwen\u2019s Small animal Clinical Oncology, Elsevier, Inc.. [6th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Muller, J., Henrich, M., Hoogen-Merkel, J., and Hartung, S. (2022). Granulation tissue-type hemangioma in a 6-week-old puppy\u2014A case report. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03503-1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.exphem.2006.04.013","article-title":"Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation","volume":"34","author":"Helm","year":"2006","journal-title":"Exp. Hematol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/vetsci2040388","article-title":"Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives","volume":"2","author":"Kim","year":"2015","journal-title":"Vet. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Choi, E.W. (2019). Deep dermal and subcutaneous canine hemangiosarcoma in the perianal area: Diagnosis of perianal mass in a dog. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-019-1852-6"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2460\/javma.1991.198.05.891","article-title":"Evaluation of hemostatic defects secondary to vascular tumors in dogs: 11 cases (1983\u20131988)","volume":"198","author":"Hargis","year":"1991","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1939-1676.1991.tb00923.x","article-title":"Hemostatic abnormalities in dogs with hemangiosarcoma","volume":"5","author":"Hammer","year":"1991","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1292\/jvms.66.573","article-title":"The incidence of disseminated intravascular coagulation in dogs with malignant tumor","volume":"66","author":"Maruyama","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2460\/javma.232.4.553","article-title":"Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003\u20132005)","volume":"232","author":"Hammond","year":"2008","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Meuten, D.J. (2017). Tumors in Domestic Animals, Wiley-Blackwell. [5th ed.].","DOI":"10.1002\/9781119181200"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1939-165X.2005.tb00005.x","article-title":"Canine angiosarcoma: Cytologic, histologic, and immunohistochemical correlations","volume":"34","author":"Bertazzolo","year":"2008","journal-title":"Vet. Clin. Path."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Brooks, M.B., Harr, K.E., Seelig, D.M., Wardrop, K.J., and Weiss, D.J. (2022). Schalm\u2019s Veterinary Hematology, Wiley-Blackwel. [7th ed.].","DOI":"10.1002\/9781119500537"},{"key":"ref_14","unstructured":"Thrall, M.A., Weiser, G., Allison, R.W., and Campbell, T.W. (2022). Veterinary Hematology, Clinical Chemistry, and Cytology, Wiley-Blackwell. [3rd ed.]."},{"key":"ref_15","first-page":"63","article-title":"Canine neoplasia--population-based incidence of vascular tumours","volume":"125","author":"Moe","year":"2008","journal-title":"APMIS Suppl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/vco.12574","article-title":"Refining the \u201cdouble two-thirds\u201d rule: Genotype-based breed grouping and clinical presentation help predict the diagnosis of canine splenic mass lesions in 288 dogs","volume":"18","author":"Davies","year":"2020","journal-title":"Vet. Comp. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/030098589202900406","article-title":"A retrospective clinicopathologic study of 212 dogs with cutaneous hemangiomas and hemangiosarcomas","volume":"29","author":"Hargis","year":"1992","journal-title":"Vet. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0463.2008.125m4.x","article-title":"Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs","volume":"125","author":"Gamlem","year":"2008","journal-title":"APMIS Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1902\/jop.2002.73.7.701","article-title":"Pathogenetic roles of angiogenic factors in pyogenic granulomas in pregnancy are modulated by female sex hormones","volume":"73","author":"Yuan","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"645678","DOI":"10.1155\/2012\/645678","article-title":"Hemangiomas and vascular malformations: Current theory and management","volume":"2012","author":"Richter","year":"2012","journal-title":"Int. J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gross, T.L., Ihrke, P.J., Walder, E.J., and Affolter, V.K. (2005). Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis, Blackwell Science Ltd.. [2nd ed.].","DOI":"10.1002\/9780470752487"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/104063870401600606","article-title":"A retrospective study of visceral and nonvisceral hemangiosarcoma and hemangiomas in domestic animals","volume":"16","author":"Schultheiss","year":"2004","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cvsm.2019.04.009","article-title":"Histiocytic Sarcoma and Hemangiosarcoma Update","volume":"49","author":"Mullin","year":"2019","journal-title":"Vet. Clin. North. Am. Small Anim. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5326\/0450072","article-title":"Prognosis for acute nontraumatic hemoperitoneum in the dog: A retrospective analysis of 60 cases (2003\u20132006)","volume":"45","author":"Aronsohn","year":"2009","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1292\/jvms.13-0064","article-title":"Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: A review of 51 cases","volume":"75","author":"Yamamoto","year":"2013","journal-title":"J. Vet. Med. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/vco.12167","article-title":"A descriptive review of cardiac tumours in dogs and cats","volume":"15","author":"Treggiari","year":"2017","journal-title":"Vet. Comp. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5326\/JAAHA-MS-5603","article-title":"Concurrent splenic and right atrial mass at presentation in dogs with HSA: A retrospective study","volume":"47","author":"Boston","year":"2011","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/vsu.12361","article-title":"Erythrocyte and Biochemical Abnormalities as Diagnostic Markers in Dogs With Hemangiosarcoma Related Hemoabdomen","volume":"44","author":"Wong","year":"2015","journal-title":"Vet. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cvsm.2011.09.009","article-title":"Hematologic abnormalities in the small animal cancer patient","volume":"42","author":"Childress","year":"2012","journal-title":"Vet. Clin. North. Am. Small Anim. Pract."},{"key":"ref_30","first-page":"889","article-title":"Hemangiosarcoma in a geriatric Labrador retriever","volume":"53","author":"Sharma","year":"2012","journal-title":"Can. Vet. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2460\/javma.258.6.630","article-title":"Retrospective evaluation of thrombocytopenia and tumor stage as prognostic indicators in dogs with splenic hemangiosarcoma","volume":"258","author":"Masyr","year":"2021","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/jvim.16828","article-title":"A prospective evaluation of the prevalence of thromboemboli and associated hemostatic dysfunction in dogs with carcinoma or sarcoma","volume":"37","author":"Pazzi","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1751-0147-54-3","article-title":"Haemostatic alterations in a group of canine cancer patients are associated with cancer type and disease progression","volume":"54","author":"Andreasen","year":"2012","journal-title":"Acta Vet. Scand."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/5\/189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:54Z","timestamp":1760106834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/5\/189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["vetsci11050189"],"URL":"https:\/\/doi.org\/10.3390\/vetsci11050189","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}