{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:23:27Z","timestamp":1781227407514,"version":"3.54.1"},"reference-count":18,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Myocardial protection has become an essential adjunctive procedure in veterinary cardiac surgery. Del Nido cardioplegia is a good alternative to the traditional St. Thomas II (ST) cardioplegia in open heart surgery in humans. This study aims to compare intra- and postoperative results between ST cardioplegia and modified del Nido (mDN) cardioplegia in mitral valve surgery in dogs with myxomatous mitral valve disease (MMVD). This retrospective study was conducted using clinical records of 16 MMVD dogs that underwent either ST or mDN cardioplegia. We measured cardiopulmonary bypass (CPB) time, aortic cross-clamp (ACC) time, total operation time, the number of cardioplegia doses, total amount of cardioplegia, required defibrillations, in-hospital mortality and pre- and one-month postoperative echocardiographic variables. CPB (159.4 \u00b1 16.1 vs. 210.1 \u00b1 34.0 min), ACC (101.4 \u00b1 7.0 vs. 136.0 \u00b1 24.8 min) and total operation time (262.3 \u00b1 13.1 vs. 327.0 \u00b1 45.4 min) were significantly shorter in the mDN group (p &lt; 0.05). The number of cardioplegia doses (3.25 \u00b1 0.4 vs. 6.25 \u00b1 1.2) and total amount of cardioplegia (161.3 \u00b1 51.5 vs. 405.0 \u00b1 185.9 mL) in the mDN group were also significantly smaller than the ST group (p &lt; 0.05). No difference was observed in the requirement of defibrillation, in-hospital mortality and pre- and postoperative echocardiographic variables. The utilization of mDN cardioplegia was associated with shorter operative time in mitral valve surgery in dogs.<\/jats:p>","DOI":"10.3390\/vetsci11050201","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:27:00Z","timestamp":1715002020000},"page":"201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of St. Thomas II Cardioplegia and Modified Del Nido Cardioplegia in Dogs Undergoing Mitral Valve Surgery"],"prefix":"10.3390","volume":"11","author":[{"given":"Yuki","family":"Onuma","sequence":"first","affiliation":[{"name":"VCA Japan Shiraishi Animal Hospital, Sayamadai, 4\u221233\u22122, Sayama 350-1304, Saitama, Japan"},{"name":"VCA Japan Ozenji Pet Clinic, Ozenjinishi 3-27-1, Asaoku, Kawasaki 215-0017, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-9311","authenticated-orcid":false,"given":"Tomohiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11, Inada, Obihiro 080-8555, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6047-2865","authenticated-orcid":false,"given":"Katsuhiro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Aboshi","sequence":"additional","affiliation":[{"name":"VCA Japan Shiraishi Animal Hospital, Sayamadai, 4\u221233\u22122, Sayama 350-1304, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"VCA Japan Shiraishi Animal Hospital, Sayamadai, 4\u221233\u22122, Sayama 350-1304, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusaku","family":"Yamada","sequence":"additional","affiliation":[{"name":"VCA Japan Shiraishi Animal Hospital, Sayamadai, 4\u221233\u22122, Sayama 350-1304, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youta","family":"Yaginuma","sequence":"additional","affiliation":[{"name":"VCA Japan Shiraishi Animal Hospital, Sayamadai, 4\u221233\u22122, Sayama 350-1304, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/jvim.15488","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene","year":"2019","journal-title":"J. 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Dev."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/5\/201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:39:50Z","timestamp":1760107190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/5\/201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,5]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["vetsci11050201"],"URL":"https:\/\/doi.org\/10.3390\/vetsci11050201","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,5]]}}}