{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:14:31Z","timestamp":1787030071988,"version":"build-2736575974"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agria Pet Insurance Research Foundation","award":["N2013-0005"],"award-info":[{"award-number":["N2013-0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>(1) Background: The aim of the current pilot study was to describe the long-term effects of a single intra-articular injection of autologous stromal vascular fraction (SVF) with platelet-rich plasma (PRP) in dogs with confirmed elbow OA, using orthopedic lameness scoring and kinetic and kinematic gait analysis. For comparison of normal long-term variation of gait over time, a group of healthy control dogs (CDs) was also evaluated. (2) Methods: A prospective longitudinal clinical pilot study investigating 19 client-owned dogs with elbow OA (OADs) treated with SVF and PRP and eight CDs not receiving treatment. The OAD and CD groups were evaluated before and after 6 and at least 12 months following treatment with SVF and PRP (OAD group) and twice with a six-month interval (CD group), respectively, through orthopedic examinations, goniometry, and kinetic and kinematic analyses (seven variables). (3) Results: The OAD had an increase in fore\u2013hind peak force symmetry \u226512 months after treatment (p &lt; 0.05), but no other objective variables changed over time. Orthopedic consensus scores had improved at \u2265six months follow-up evaluation (p &lt; 0.05). None of the investigated gait variables had changed at \u2265six months follow-up evaluation in the CD group. (4) Conclusions: The current study could not confirm a significant benefit from SVF and PRP treatment in OADs, but future studies should be conducted in order to fully evaluate the potential of the treatment. The improvement seen in fore\u2013hindlimb symmetry may represent an improvement in gait or an incidental finding.<\/jats:p>","DOI":"10.3390\/vetsci11070296","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T08:17:29Z","timestamp":1719821849000},"page":"296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Effect of Intra-Articular Adipose-Derived Stromal Vascular Fraction and Platelet-Rich Plasma in Dogs with Elbow Joint Disease\u2014A Pilot Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-8747","authenticated-orcid":false,"given":"Annika","family":"Bergstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, P.O. Box 7070, 75007 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kj\u00f6rk Granstr\u00f6m","sequence":"additional","affiliation":[{"name":"University Animal Hospital, Swedish University of Agricultural Sciences, Ultunaall\u00e9n 5A, P.O. Box 7070, 75007 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-9284","authenticated-orcid":false,"given":"Lars","family":"Roepstorff","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Biochemistry, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, P.O. Box 7070, 75007 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-6122","authenticated-orcid":false,"given":"Mohammad J.","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Agnes Sj\u00f6berginkatu 2, P.O. Box 66, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjerstin","family":"Pettersson","sequence":"additional","affiliation":[{"name":"University Animal Hospital, Swedish University of Agricultural Sciences, Ultunaall\u00e9n 5A, P.O. Box 7070, 75007 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6617-0454","authenticated-orcid":false,"given":"Ingrid","family":"Ljungvall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, P.O. Box 7070, 75007 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref_1","first-page":"711","article-title":"Elbow Incongruity and Developmental Elbow Diseases in the Dog: Part 1","volume":"22","author":"Wind","year":"1986","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_2","first-page":"725","article-title":"Elbow Incongruity and Deveopmental Elbow Diseases in the Dog: Part II","volume":"22","author":"Wind","year":"1986","journal-title":"J. Am. Anim. Hosp. 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