{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T02:41:41Z","timestamp":1764470501659,"version":"build-2065373602"},"reference-count":112,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Timisoara University of Life Sciences \u201cKing Mihai I\u201d","award":["PNURSP2024R318","RSP-2024\/R232"],"award-info":[{"award-number":["PNURSP2024R318","RSP-2024\/R232"]}]},{"name":"Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia","award":["PNURSP2024R318","RSP-2024\/R232"],"award-info":[{"award-number":["PNURSP2024R318","RSP-2024\/R232"]}]},{"name":"King Saud University, Riyadh, Saudi Arabia","award":["PNURSP2024R318","RSP-2024\/R232"],"award-info":[{"award-number":["PNURSP2024R318","RSP-2024\/R232"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Determining the gene expression and serum profile of the indicators linked to clinical endometritis susceptibility in Egyptian buffalo cows was the aim of this investigation. The buffalo cows that were enrolled were divided into two groups: forty infected buffalo cows with clinical endometritis and forty seemingly healthy buffalo cows that served as the control group. For the purposes of gene expression and biochemical analysis, ten milliliters of blood was obtained via jugular venipuncture from each buffalo cow. TLR4, IL-8, IL-17, NFKB, SLCA11A1, NCF4, Keap1, HMOX1, OXSR1, ST1P1, and SERP1 were manifestly expressed at much higher levels in the buffaloes with endometritis. On the other hand, the genes that encode SOD, CAT, NDUFS6, Nrf2, and PRDX2 were down-regulated. There was a significant (p &lt; 0.05) elevation of the serum levels of non-esterified fatty acids (NEFAs), beta hydroxy butyric acid (BHBA), triglycerides (TGs), globulin, creatinine, and cortisol, along with a reduction in the serum levels of glucose, cholesterol, total protein albumin, urea, estrogen (E2), progesterone (P4), follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroxine (T4), prostaglandin F2 \u03b1 (PGF2\u03b1), calcium, iron, and selenium, in the endometritis group in comparison with the control. However, no significant change was observed in the values of phosphorus, magnesium, copper, or zinc in either group. Within the selective breeding of naturally resistant animals, the variation in the genes under study and the changes in the serum profiles of the indicators under investigation may serve as a reference guide for reducing endometritis in Egyptian buffalo cows.<\/jats:p>","DOI":"10.3390\/vetsci11080340","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T09:50:05Z","timestamp":1722246605000},"page":"340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Transcript Levels and the Serum Profile of Biomarkers Associated with Clinical Endometritis Susceptibility in Buffalo Cows"],"prefix":"10.3390","volume":"11","author":[{"given":"Ahmed","family":"El-Sayed","sequence":"first","affiliation":[{"name":"Department of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC), Cairo 11753, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-7396","authenticated-orcid":false,"given":"Salah H.","family":"Faraj","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Misan, Maysan 62001, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-3885","authenticated-orcid":false,"given":"Basma H.","family":"Marghani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Physiology, and Pharmacology, Faculty of Veterinary Medicine, King Salman International University, South of Sinai 46612, Egypt"},{"name":"Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-614X","authenticated-orcid":false,"given":"Fatmah A.","family":"Safhi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-3420","authenticated-orcid":false,"given":"Mohamed","family":"Abdo","sequence":"additional","affiliation":[{"name":"Department of Animal Histology and Anatomy, School of Veterinary Medicine, Badr University in Cairo (BUC), Cairo 11829, Egypt"},{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana","family":"Fericean","sequence":"additional","affiliation":[{"name":"Department of Biology and Plant Protection, Faculty of Agricultural Sciences, University of Life Sciences King Michael I, 300645 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioan","family":"Banatean-Dunea","sequence":"additional","affiliation":[{"name":"Department of Biology and Plant Protection, Faculty of Agricultural Sciences, University of Life Sciences King Michael I, 300645 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cucui-Cozma","family":"Alexandru","sequence":"additional","affiliation":[{"name":"Tenth Department of Surgery, Victor Babe\u0219 University of Medicine and Pharmacy, 300645 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad R.","family":"Alhimaidi","sequence":"additional","affiliation":[{"name":"Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-8446","authenticated-orcid":false,"given":"Aiman A.","family":"Ammari","sequence":"additional","affiliation":[{"name":"Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-5044","authenticated-orcid":false,"given":"Attia","family":"Eissa","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine, Arish University, Arish 45511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Ateya","sequence":"additional","affiliation":[{"name":"Department of Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.anireprosci.2010.08.022","article-title":"Reproductive cycles of buffalo","volume":"124","author":"Perera","year":"2011","journal-title":"Anim. Reprod. 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