{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:44:59Z","timestamp":1789083899492,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Researchers Supporting Project (RSP2024R25), King Saud University, Riyadh, Saudi Arabia","award":["RSP2024R25"],"award-info":[{"award-number":["RSP2024R25"]}]},{"name":"Researchers Supporting Project (RSP2024R25), King Saud University, Riyadh, Saudi Arabia","award":["PNURSP2024R96"],"award-info":[{"award-number":["PNURSP2024R96"]}]},{"name":"Princess Nourah bint Abdulrahman University Researchers Supporting Project (PNURSP2024R96), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia","award":["RSP2024R25"],"award-info":[{"award-number":["RSP2024R25"]}]},{"name":"Princess Nourah bint Abdulrahman University Researchers Supporting Project (PNURSP2024R96), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia","award":["PNURSP2024R96"],"award-info":[{"award-number":["PNURSP2024R96"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Eimeria is a parasite that causes coccidiosis in a variety of animals, leading to nutritional imbalances, issues with food digestion and absorption, low weight, and intestinal inflammation of varying degrees in its hosts. Anticoccidial medication resistance has become a significant obstacle to disease control efforts, leading to a renewed focus on discovering novel chemicals for alternative therapeutic approaches. The purpose of this study was to determine the efficacy of Holothuria polii extract (HpE) in treating eimeriosis in mice. Five groups of mice were studied, with E. papillata sporulated oocysts (1 \u00d7 103) used to infect three groups experimentally. The first group was treated with 200 mg\/kg of HpE, the second group with Amprolium (120 mg\/kg), and the third group was left untreated as a control. The fourth and fifth groups were uninfected, with one of them treated with 200 mg\/kg of HpE and the other used as a negative control. The results revealed that HpE has 10 phytochemical compounds according to GC-MS analysis. Treatment with HpE resulted in a substantial decrease in oocyst output in feces. Also, the parasitic stages showed morphometric alterations, with reductions in the measurements compared with the infected, untreated mice. Moreover, expression of the mucin gene (MUC2) was higher in treated mice compared to infected ones, with significant increases in goblet cell numbers, which provided additional evidence for the activity of HpE as an anticoccidial product. In conclusion, there are a wide variety of natural products and many have been employed in folk medicine for treating a range of parasitic diseases.<\/jats:p>","DOI":"10.3390\/vetsci11100490","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T07:53:05Z","timestamp":1728546785000},"page":"490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Holothuria polii Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum"],"prefix":"10.3390","volume":"11","author":[{"given":"Youssef A.","family":"El-Sayed","sequence":"first","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11759, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-2591","authenticated-orcid":false,"given":"Ahmed E.","family":"Abdel-Moneim","sequence":"additional","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11759, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania G.","family":"Taha","sequence":"additional","affiliation":[{"name":"Biological and Geological Sciences Department, Faculty of Education, Ain Shams University, Roxy, Heliopolis, Cairo 11757, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona F.","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11759, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-6871","authenticated-orcid":false,"given":"Rewaida","family":"Abdel-Gaber","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2463","authenticated-orcid":false,"given":"Felwa A.","family":"Thagfan","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8178-8395","authenticated-orcid":false,"given":"Esam S.","family":"Al-Malki","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science in Zulfi, Majmaah 11952, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":false,"given":"Mohamed A.","family":"Dkhil","sequence":"additional","affiliation":[{"name":"Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11759, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0020-7519(99)00086-7","article-title":"A compartmentalised model for the estimation of the cost of coccidiosis to the world\u2019s chicken reproduction industry","volume":"29","author":"Williams","year":"1999","journal-title":"Int. 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