{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:16:20Z","timestamp":1789197380839,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The present study aimed to evaluate the effects of chronic pimobendan monotherapy on cardiac size in dogs with stage B2 myxomatous mitral valve disease (MMVD). Data from 31 dogs diagnosed with MMVD and cardiomegaly (LA\/Ao \u2265 1.6 and LVIDdn \u2265 1.7) were included. The intervention group were dogs treated with pimobendan (n = 24). Dogs not receiving any cardiac medication were controls (n = 7). Echocardiographic changes in left atrial and left ventricular dimensions were compared over time. There was significant group \u00d7 time interaction for LVIDdN (p = 0.011) between diagnosis and initial follow-up (median 3\u20136 months). There was a significant reduction in LVIDdN over time in the pimobendan group (p = 0.038) but not in the control group (p = 0.216). There was no significant group \u00d7 time interaction for LA\/Ao, and there was no effect of group (p = 0.561), but LA\/Ao in both groups decreased over time (p = 0.01). Restraint is advised when prescribing pimobendan based on the detection of a heart murmur where echocardiographic staging is an option. Some stage B2 dogs that received pimobendan no longer met the echocardiographic classification criteria for stage B2 MMVD and could have been misclassified as stage B1 and had their medication inappropriately withdrawn. We suggest these dogs are referred to as reverse remodelled stage B2.<\/jats:p>","DOI":"10.3390\/vetsci11120594","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T09:59:34Z","timestamp":1732528774000},"page":"594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Echocardiographic Changes in Dogs with Stage B2 Myxomatous Mitral Valve Disease Treated with Pimobendan Monotherapy"],"prefix":"10.3390","volume":"11","author":[{"given":"Andrew","family":"Crosland","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Science, School of Veterinary Science, University of Liverpool, Cardiology Service, Small Animal Teaching Hospital, Chester High Road, Neston CH64 7TE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Manuel","family":"Cortes-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, School of Veterinary Science, University of Liverpool, Cardiology Service, Small Animal Teaching Hospital, Chester High Road, Neston CH64 7TE, UK"},{"name":"The Royal (Dick) School of Veterinary Studies, Easter Bush Campus, The University of Edinburgh, Cardiology Service, Hospital for Small Animals, Midlothian EH25 9RG, UK"},{"name":"Peripatetic Cardiology, Casar de Periedo, Cabez\u00f3n de la Sal, 39591 Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Sudunagunta","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, School of Veterinary Science, University of Liverpool, Cardiology Service, Small Animal Teaching Hospital, Chester High Road, Neston CH64 7TE, UK"},{"name":"Willows Veterinary Centre and Referral Service, Highlands Road, Shirley, Solihull B90 4NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bouvard","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies, Easter Bush Campus, The University of Edinburgh, Cardiology Service, Hospital for Small Animals, Midlothian EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Bode","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, School of Veterinary Science, University of Liverpool, Cardiology Service, Small Animal Teaching Hospital, Chester High Road, Neston CH64 7TE, UK"},{"name":"ChesterGates Veterinary Specialists, Units E & F, Telford Court, Gates Lane, Chester CH1 6LT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-6178","authenticated-orcid":false,"given":"Geoff","family":"Culshaw","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies, Easter Bush Campus, The University of Edinburgh, Cardiology Service, Hospital for Small Animals, Midlothian EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-8251","authenticated-orcid":false,"given":"Joanna","family":"Dukes-McEwan","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, School of Veterinary Science, University of Liverpool, Cardiology Service, Small Animal Teaching Hospital, Chester High Road, Neston CH64 7TE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cvsm.2010.03.008","article-title":"Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy","volume":"40","author":"Borgarelli","year":"2010","journal-title":"Vet. 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