{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:53:52Z","timestamp":1792806832803,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico, Brazil)","id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"FAPEMIG (Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais, Brazil)","id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brazil)","id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Pseudoplacentational endometrial hyperplasia (PEH) and cystic endometrial hyperplasia (CEH) are both hyperplastic conditions that may occur in the canine uterus during diestrus. CEH can impair fertility, and, although the consequences of PEH are poorly known, this condition is significantly associated with pyometra. The aim of this study was to investigate frequencies of both PEH and CEH in female dogs according to age, size, breed, and breed group. Uteri from 300 female dogs were sampled and processed for histopathologic analyses. Lesions were identified, and frequencies were statistically compared. PEH was significantly more frequent in dogs between 4 and 12 years of age and significantly less frequent in Yorkshires than Shih-tzus, as well as in the breed group that includes Brazilian Terriers and Yorkshires. CEH was significantly more frequent in dogs older than 12 years, but no breed predisposition was observed. The frequency of PEH was significantly higher than that of CEH. The frequency of pyometra in PEH cases was significantly higher than endometritis or uterus without inflammation. This study identified age, breed group, and size as predisposing factors for PEH and further demonstrated the association between this condition and pyometra in dogs.<\/jats:p>","DOI":"10.3390\/vetsci12010001","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:10:49Z","timestamp":1735182649000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predisposing Factors for Pseudoplacentational Endometrial Hyperplasia or Cystic Endometrial Hyperplasia in Dogs and Their Association with Pyometra"],"prefix":"10.3390","volume":"12","author":[{"given":"Clarissa Helena","family":"Santana","sequence":"first","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique Ferreira","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-5953","authenticated-orcid":false,"given":"Laice Alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-5348","authenticated-orcid":false,"given":"Lucas dos Reis","family":"de Souza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Marcos","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria, Campus Regional de Umuarama, Universidade Estadual de Maring\u00e1, Umuarama 87506-370, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayisa Rodrigues","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Alves","family":"da Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-0470","authenticated-orcid":false,"given":"Renato Lima","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","unstructured":"McEntee, K. 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