{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:23:43Z","timestamp":1773005023141,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>A 3-year-old spayed male mixed-breed Labrador presented to the Emergency and Critical Care Unit with lethargy, loss of appetite, vomiting, a recent history of presyncopal episodes, and severe exercise intolerance. On admission, the patient had bradycardia, low blood pressure, and mild abdominal pain. Serum biochemistry information revealed severe hyperkalemia, hyponatremia, hypoglycemia, and mildly increased liver and kidney parameters. Upon taking these findings into consideration, hypoadrenocorticism was suspected, and a basal cortisol level was determined; it was below 1.0 \u00b5g\/dL. Upon examination with ultrasound, we observed that the size of the adrenal glands was considerably reduced. Due to the bradycardia, a complete cardiologic examination consisting of 5 min of six-lead electrocardiography and echocardiography (ECG) was performed. Six-lead ECG revealed a complete atrio-ventricular block with an atrial rate of 140 bpm and a ventricular rate of 60 bpm. The PQ interval was variable, without any evidence of atrio-ventricular conduction. Treatment for hyperkalemia was initiated immediately after admission, followed by dexamethasone sodium phosphate administration, which led to an improvement in the patient\u2019s general condition, and the normalization of the ECG readings, after 24 h of therapy. Afterward, prednisolone (0.5 mg\/kg\/24 h p.o.) and desoxycorticosterone pivalate (2.2 mg\/kg s.c.) were administered. This case shows that a third-degree atrioventricular block might be a reversible problem in dogs with hypoadrecorticism that can be managed with specific treatment for this disorder, without requiring pacemaker implantation.<\/jats:p>","DOI":"10.3390\/vetsci12010063","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:46:10Z","timestamp":1737009970000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient Third-Degree Atrioventricular Block in a Dog with Addisonian Crisis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9487-9144","authenticated-orcid":false,"given":"Paula Maria","family":"Pa\u0219ca","sequence":"first","affiliation":[{"name":"Department of Clinics, Faculty of Veterinary Medicine, \u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-9574","authenticated-orcid":false,"given":"Gheorghe","family":"Solcan","sequence":"additional","affiliation":[{"name":"Department of Clinics, Faculty of Veterinary Medicine, \u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Blageanu","sequence":"additional","affiliation":[{"name":"Department of Clinics, Faculty of Veterinary Medicine, \u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Maria","family":"L\u0103c\u0103tu\u0219","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-8305","authenticated-orcid":false,"given":"Petru Cosmin","family":"Pe\u0219tean","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin Adrian","family":"Stancu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Life Sciences \u201cKing Mihai I\u201d, 300645 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7054-4650","authenticated-orcid":false,"given":"Andrei Radu","family":"Baisan","sequence":"additional","affiliation":[{"name":"Department of Clinics, Faculty of Veterinary Medicine, \u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.tcam.2014.10.001","article-title":"Canine hypoadrenocorticism: Pathogenesis, diagnosis, and treatment","volume":"29","author":"Sande","year":"2014","journal-title":"Top. Companion Anim. Med."},{"key":"ref_2","first-page":"63","article-title":"Canine hypoadrenocorticism: Part I","volume":"51","author":"Klein","year":"2010","journal-title":"Can. Vet. J."},{"key":"ref_3","unstructured":"Ettinger, S.J., Feldman, E.C., and Cote, E. (2017). Textbook of Veterinary Internal Medicine, Elsevier. [8th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1196\/annals.1353.038","article-title":"Biochemical diagnosis and localization of pheochromocytoma: Can we reach a consensus?","volume":"1073","author":"Grossman","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1939-1676.1997.tb00464.x","article-title":"Pheochromocytoma in dogs: 61 cases (1984\u20131995)","volume":"11","author":"Barthez","year":"1997","journal-title":"J. Vet. Intern. Med."},{"key":"ref_6","unstructured":"Santilli, R., Mo\u00efse, S., Pariaut, R., and Perego, M. (2018). Electrocardiography of the Dog and Cat, EDRA. [2nd ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1740-8261.2002.tb01051.x","article-title":"Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in cavalier King Charles spaniels with and without left atrial enlargement","volume":"43","author":"Hansson","year":"2002","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_8","first-page":"311","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2460\/javma.231.3.413","article-title":"Use of basal serum or plasma cortisol concentrations to rule out a diagnosis of hypoadrenocorticism in dogs: 123 cases (2000\u20132005)","volume":"231","author":"Lennon","year":"2007","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5326\/JAAHA-MS-5868","article-title":"American Association of Feline Practicioners; American Animal Hospital Association. 2013 AAHA\/AAFP fluid therapy guidelines for dogs and cats","volume":"49","author":"Davis","year":"2013","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/vru.13151","article-title":"ACVR and ECVDI consensus statement for the standardization of the abdominal ultrasound examination","volume":"63","author":"Seiler","year":"2022","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2460\/ajvr.1990.51.04.625","article-title":"X-ray-computed tomography, nephrotomography, and ultrasonography of the adrenal glands of healthy dogs","volume":"51","author":"Voorhout","year":"1990","journal-title":"Am. J. Vet. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0195-5616(98)50082-4","article-title":"Ultrasonography of the adrenal glands in the dog, cat, and ferret","volume":"28","author":"Barthez","year":"1998","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13256-020-02644-x","article-title":"Transient complete atrioventricular block and ST-segment elevation induced by coronary vasospasm due to iatrogenic hyperkalemia: A case report","volume":"15","author":"Cao","year":"2021","journal-title":"J. Med. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2460\/javma.248.6.652","article-title":"Associations between sex, body weight, age, and ultrasonographically determined adrenal gland thickness in dogs with non-adrenal gland illness","volume":"248","author":"Bento","year":"2016","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1136\/hrt.2004.046524","article-title":"Hyperkalaemia induced complete atrioventricular block with a narrow QRS complex","volume":"91","author":"Kim","year":"2005","journal-title":"Heart"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1751-0813.2003.tb11544.x","article-title":"Complete heart block associated with lupus in a dog","volume":"81","author":"Malik","year":"2003","journal-title":"Aust. Vet. J."},{"key":"ref_18","first-page":"25","article-title":"Infection and Twiddler syndrome in a dog with Addison\u2019s disease, complete heart block, and wandering artificial pacemakers","volume":"26","author":"Buchanan","year":"1990","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2460\/javma.244.9.1033","article-title":"ECG of the Month. Third degree atrioventricular block","volume":"244","author":"Cook","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/jsap.13464","article-title":"Third-degree atrioventricular block with narrow QRS complexes in a case of hypoadrenocorticism in a dog","volume":"63","author":"McGrath","year":"2022","journal-title":"J. Small Anim. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/vr.c4235","article-title":"Ultrasonographic evaluation of adrenal glands in dogs with primary hypoadrenocorticism or mimicking diseases","volume":"167","author":"Wenger","year":"2010","journal-title":"Vet. Rec."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5326\/15473317-35-3-214","article-title":"Ultrasonographic evaluation of the adrenal glands in six dogs with hypoadrenocorticism","volume":"35","author":"Hoerauf","year":"1999","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_23","unstructured":"Feldman, E.C., Nelson, R.W., Reusch, C.E., and Scott-Moncrieff, J.C.R. (2015). Canine and Feline Endocrinology, Elsevier."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1939-1676.2007.tb01933.x","article-title":"Abnormalities of serum electrolyte concentrations in dogs with hypoadrenocorticism","volume":"21","author":"Adler","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/jvim.12415","article-title":"Basal serum cortisol concentration as a screening test for hypoadrenocorticism in dogs","volume":"28","author":"Bovens","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1002\/vetr.80","article-title":"Ultrasound evaluation of adrenal gland size in clinically healthy dogs and in dogs with hyperadrenocorticism","volume":"188","author":"Saavedra","year":"2021","journal-title":"Vet. Rec."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2460\/ajvr.1993.54.11.1954","article-title":"Toxicity of desoxycorticosterone pivalate given at high dosages to clinically normal beagles for six months","volume":"54","author":"Chow","year":"1993","journal-title":"Am. J. Vet. 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