{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:35:07Z","timestamp":1792290907867,"version":"4.4.0"},"reference-count":97,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The concerns regarding Fowl Adenoviruses have gained significance in the poultry industry due to their association with various diseases, including Inclusion Body Hepatitis, Hepatitis-Hydropericardium Syndrome, and Adenoviral Gizzard Erosion (AGE). AGE is an emerging disease reported in several countries, particularly in Asia and Europe, causing significant economic losses in the poultry industry. In 2001, Fowl Adenovirus Serotype 1 was identified as the etiological agent of AGE in Japan. Since then, it has been spreading to other countries due to its transmission mode. Although Adenoviral Gizzard Erosion has been mostly described in broilers, it has also been observed in layers and pullets. This review offers a comprehensive analysis of Fowl Adenovirus Serotype 1, encompassing various key aspects of the virus. We also examine the pathogenesis and epidemiology of the virus, providing an overview of its distribution and prevalence in avian populations worldwide. Highlighting the most recent developments in serological and molecular techniques for virus detection, quantification, and genotyping and comparing them to conventional tests, this review aims to contribute to the understanding of the diagnostic workflow for this virus. Lastly, this review sheds light on some vaccine strategies to prevent Adenoviral Gizzard Erosion.<\/jats:p>","DOI":"10.3390\/vetsci12040378","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T20:50:46Z","timestamp":1744923046000},"page":"378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fowl Adenovirus Serotype 1: From Gizzard Erosion to Comprehensive Insights into Genome Organization, Epidemiology, Pathogenesis, Diagnosis, and Prevention"],"prefix":"10.3390","volume":"12","author":[{"given":"Amina","family":"Kardoudi","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology and Public Health, Agronomy and Veterinary Institute Hassan II, Rabat-Instituts, Rabat 10101, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelouhab","family":"Benani","sequence":"additional","affiliation":[{"name":"Medical Biology Department, Molecular Biology Laboratory, Pasteur Institute of Morocco, Casablanca 20360, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmounaaim","family":"Allaoui","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory\/African Genome Center, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-9128","authenticated-orcid":false,"given":"Faouzi","family":"Kichou","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology and Public Health, Agronomy and Veterinary Institute Hassan II, Rabat-Instituts, Rabat 10101, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-0792","authenticated-orcid":false,"given":"Latefa","family":"Biskri","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory\/African Genome Center, Mohammed VI Polytechnic University, Ben Guerir 43150, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Ouchhour","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology and Public Health, Agronomy and Veterinary Institute Hassan II, Rabat-Instituts, Rabat 10101, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-3746","authenticated-orcid":false,"given":"Siham","family":"Fellahi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology and Public Health, Agronomy and Veterinary Institute Hassan II, Rabat-Instituts, Rabat 10101, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2307\/1593040","article-title":"Epizootic Outbreaks of Gizzard Erosion Associated with Adenovirus Infection in Chickens","volume":"45","author":"Ono","year":"2001","journal-title":"Avian Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.meegid.2016.12.008","article-title":"Whole genome sequencing of Fowl aviadenovirus A\u2014A causative agent of gizzard erosion and ulceration, in adult laying hens","volume":"48","author":"Matczuk","year":"2017","journal-title":"Infect. 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