{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:30:15Z","timestamp":1766068215876,"version":"build-2065373602"},"reference-count":83,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This study aimed to investigate the effects of 1,25-Dihydroxycholecalciferol glycoside (1,25(OH)2D3-G) supplementation on the performance, biochemical blood, bone health, intestinal histomorphometry, and gene expressions in broilers from breeders supplemented or not with 1,25(OH)2D3-G. A total of 1152 one-day-old, male Ross 308 AP chicks were distributed in a completely randomized design with a 2 \u00d7 3 factorial arrangement. One factor was the inclusion or not of 1,25(OH)2D3-G in the breeders\u2019 diets from 21 to 62 weeks of age. The other factor involved three levels (0, 50, and 100 mg\/kg) of 1,25(OH)2D3-G inclusion in the broilers\u2019 diets from 1 to 21 days of age. The study totaled six treatments, with eight replicates and 24 birds per experimental unit. Breeders supplemented with of 1,25(OH)2D3-G resulted in heavier broiler chicks at hatch, better feed conversion, and higher concentrations of calbindin D28K, interleukin 10, and interleukin 1\u03b2 at 21 days of age. Villus height and absorption area in the jejunum showed interactions between breeder supplementation and broiler diets. The inclusion of this additive in both diets was not sufficient to increase villus height and absorption area in broilers at 21 days of age. It is concluded that supplementation in breeders improves growth and immunity in broilers.<\/jats:p>","DOI":"10.3390\/vetsci12050434","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:44:58Z","timestamp":1746171898000},"page":"434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of 1,25-Dihydroxycholecalciferol Glycoside Supplementation on the Growth, Intestinal Health, and Immunity of Broilers from Breeders Supplemented or Not with the Same Additive"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-2059","authenticated-orcid":false,"given":"Thiago S.","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-7295","authenticated-orcid":false,"given":"Nilton","family":"Rohloff Junior","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9273-3209","authenticated-orcid":false,"given":"Paulo L. O.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-0565","authenticated-orcid":false,"given":"Bruno S.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Federal University of Uberlandia, Uberlandia 38408-100, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-5629","authenticated-orcid":false,"given":"Jos\u00e9 G.","family":"Vargas Junior","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Federal University of Esp\u00edrito Santo, Alegre 29500-00, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-3580","authenticated-orcid":false,"given":"Arele A.","family":"Calderano","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa 36570-900, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-7371","authenticated-orcid":false,"given":"Paulo C.","family":"Pozza","sequence":"additional","affiliation":[{"name":"Department of Animal Science, State University of Maring\u00e1, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-2839","authenticated-orcid":false,"given":"Leandro D.","family":"Castilha","sequence":"additional","affiliation":[{"name":"Department of Animal Science, State University of Maring\u00e1, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-0584","authenticated-orcid":false,"given":"Elcio S.","family":"Klosowski","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-3758","authenticated-orcid":false,"given":"Cinthia","family":"Eyng","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-2826","authenticated-orcid":false,"given":"Ricardo V.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Western Parana State University (Unioeste), Marechal Candido Rondon 85960-000, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5433\/1679-0359.2016v37n1p381","article-title":"Caracter\u00edsticas \u00d3sseas de Frangos de Corte Alimentados Com Ra\u00e7\u00f5es Suplementadas Com Solanum Glaucophyllum","volume":"37","author":"Vieites","year":"2016","journal-title":"Semin. 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