{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:19:21Z","timestamp":1760059161261,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Hepatic sarcomas are rare and aggressive tumors in veterinary medicine, with limited reports in the literature. This case report describes a canine hepatic myofibroblastic sarcoma in a 5-year-old spayed female Dobermann. The dog presented with abdominal enlargement and was diagnosed with a large hepatic mass following comprehensive diagnostic evaluations, including blood tests, imaging, and histopathology. Histological and immunohistochemical analyses confirmed the tumor\u2019s myofibroblastic origin, characterized by positivity for markers such as vimentin, glial fibrillary acidic protein (GFAP), nerve growth factor receptor (NGFR), alpha-smooth muscle actin (SMA), and muscular actin (HHF35). Treatment involved a combination of intense-dose chemotherapy using doxorubicin and a subsequent metronomic chemotherapy protocol, which resulted in prolonged survival of over 690 days at the time this manuscript was written. This case highlights the importance of extensive diagnostic and immunohistochemical profiling in the accurate classification of and treatment planning for hepatic sarcomas, and emphasizes the role of advanced veterinary diagnostics in improving patient outcomes. Future studies with larger sample sizes are needed to enhance understanding of the biological behavior and optimal therapeutic strategies for such rare tumors.<\/jats:p>","DOI":"10.3390\/vetsci12060521","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:52:08Z","timestamp":1748404328000},"page":"521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Histological, and Immunohistochemical Insights into a Canine Hepatic Myofibroblastic Sarcoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5651-1358","authenticated-orcid":false,"given":"Valentina","family":"Rinaldi","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-4071","authenticated-orcid":false,"given":"Laura","family":"Nordio","sequence":"additional","affiliation":[{"name":"San Marco Veterinary Clinic and Laboratory, Division of Pathology, 35030 Veggiano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-4051","authenticated-orcid":false,"given":"Massimo","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Masci","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Colli Innamorati, Via Colli Innamorati 21, 65125 Pescara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Ressel","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Physiology and Pathology, Institute of Infection, Veterinary and Ecological Science, Faculty of Health and Life Science, University of Liverpool, Chester High Road, Neston CH64 7TE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-0059","authenticated-orcid":false,"given":"Paolo Emidio","family":"Crisi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Teramo, Localit\u00e0 Piano D\u2019Accio, 64100 Teramo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1532-950X.1994.tb00496.x","article-title":"Nonlymphomatous Hepatobiliary Masses in Cats: 41 Cases (1972 to 1991)","volume":"23","author":"Lawrence","year":"1994","journal-title":"Vet. 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