{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:48:15Z","timestamp":1790876895257,"version":"4.1.0"},"reference-count":113,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PhD Scientific Research and Innovation Foundation of Sanya Yazhou Bay Science and Technology City","award":["HSPHDSRF-2023-04-014"],"award-info":[{"award-number":["HSPHDSRF-2023-04-014"]}]},{"name":"PhD Scientific Research and Innovation Foundation of Sanya Yazhou Bay Science and Technology City","award":["ZDYF2024XDNY240"],"award-info":[{"award-number":["ZDYF2024XDNY240"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["HSPHDSRF-2023-04-014"],"award-info":[{"award-number":["HSPHDSRF-2023-04-014"]}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2024XDNY240"],"award-info":[{"award-number":["ZDYF2024XDNY240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Seminal plasma, traditionally regarded as a passive transport medium for sperm, has emerged as a sophisticated biofluid orchestrating critical dialogues in reproductive physiology. Contemporary research reveals its multifunctional role in modulating endometrial receptivity through molecular priming of the female reproductive tract, a process essential for successful embryo implantation. Notably, seminal plasma contains numerous extracellular vesicles (EVs) that serve as critical mediators of intercellular communication via the regulation of biological processes in target cells. Through this sophisticated vesicular communication system, seminal plasma extracellular vesicles (SPEVs) coordinate critical reproductive events. Thus, it will be important to elucidate the molecular mechanisms by which SPEVs mediate reproductive processes, to provide knowledge that may improve fertility outcomes. Herein, we elucidated the emerging potential of SPEVs as non-invasive biomarkers for male fertility assessment and infertility diagnosis. Furthermore, this review systematically summarized current advances in SPEVs, highlighting their multifaceted roles in mediating sperm maturation, regulating sperm capacitation, and modulating embryo implantation through targeted delivery of bioactive signaling molecules.<\/jats:p>","DOI":"10.3390\/vetsci12060585","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:51:24Z","timestamp":1749808284000},"page":"585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Seminal Plasma Extracellular Vesicles: Key Mediators of Intercellular Communication in Mammalian Reproductive Systems"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-7498","authenticated-orcid":false,"given":"Yanshe","family":"Xie","sequence":"first","affiliation":[{"name":"Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya 572000, China"},{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7338-6313","authenticated-orcid":false,"given":"Chen","family":"Peng","sequence":"additional","affiliation":[{"name":"Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya 572000, China"},{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"He","sequence":"additional","affiliation":[{"name":"Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya 572000, China"},{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-3668","authenticated-orcid":false,"given":"Zhengguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Institute, Zhejiang University, Yongyou Industry Park, Yazhou Bay Sci-Tech City, Sanya 572000, China"},{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Huzhou Miemie Sheep Husbandry Co., Ltd., Huzhou 313023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, D., Wang, Z., Luo, X., Guo, H., Qiu, G., Gong, Y., Gao, H., and Cui, S. 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