{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:21:14Z","timestamp":1792387274251,"version":"4.4.0"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This study evaluates the effectiveness and financial impact of treating anoestrus dairy cows using a modified DO protocol. Among the 350 cows included in the study, 142 (40.6%) were identified as anoestrus. The average daily milk production, days in milk at artificial insemination (AI), number of AIs, and parity were 33.8 \u00b1 6.8 kg, 152.6 \u00b1 24.4 days, 1.3 \u00b1 0.2 AIs, and 1.9 \u00b1 0.8 lactations, respectively. To assess embryo survival in anoestrus dairy cows undergoing the modified DO protocol, two groups were established. The experimental group (E group, n = 74) received the GnRH agonist gonadorelin five days after TAI as part of the DO protocol. The control group (C group, n = 68) received only the DO protocol. The pregnancy rates and cumulative pregnancy rates were significantly higher in the E group (35.1% and 56.8%) compared with the C group (26.5% and 45.6%, p &lt; 0.05). A binary logistic regression analysis indicated that the interaction between treatment and anoestrus status considerably affected the pregnancy rate (p &lt; 0.001) and the occurrence of accessory corpus luteum (aCL, p &lt; 0.0001). The UW-DairyRepro$ decision support tool utilized in this study, indicated that implementing this approach could increase the net present value (NPV) by USD 54.2\/anoestrus cow\/year.<\/jats:p>","DOI":"10.3390\/vetsci12070648","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:31:57Z","timestamp":1751959917000},"page":"648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Economics of Using GnRH on Day 5 After Timed Artificial Insemination in a Modified Double-Ovsynch Protocol at a Low-Fertility Dairy Farm"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-0788","authenticated-orcid":false,"given":"Silviu-Ionu\u021b","family":"Bor\u0219","sequence":"first","affiliation":[{"name":"Research and Development Station for Cattle Breeding Dancu, 707252 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina-Mirela","family":"Ariton","sequence":"additional","affiliation":[{"name":"Research and Development Station for Cattle Breeding Dancu, 707252 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Bor\u0219","sequence":"additional","affiliation":[{"name":"\u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia-Ioana","family":"H\u00e2rbu","sequence":"additional","affiliation":[{"name":"\u201cIon Ionescu de la Brad\u201d Iasi University of Life Sciences, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Vintil\u0103","sequence":"additional","affiliation":[{"name":"Research and Development Station for Cattle Breeding Dancu, 707252 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.3168\/jds.2011-5214","article-title":"A simple formulation and solution to the replacement problem: A practical tool to assess the economic cow value, the value of a new pregnancy, and the cost of a pregnancy loss","volume":"95","author":"Cabrera","year":"2012","journal-title":"J. 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