{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:37:30Z","timestamp":1784835450965,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Veterinary Medicine Hannover, Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Since the first emergence of the Bluetongue virus (BTV) in 2006 in Northern Europe, there has been a reported association between BTV Serotype 8 (BTV-8) and brain malformations in calves. The first BTV-3 outbreak in Germany was registered in October 2023. Since then, numbers have increased steadily. In a suckler cow herd in the Lower Saxony region, two Angus calves with clinical signs of diffuse encephalopathy, including ataxia, abnormal gait, and central blindness, were born in autumn 2024. Both calves were submitted for Magnetic Resonance Imaging (MRI) and pathological examination, revealing hydranencephaly and internal hydrocephalus, respectively. BTV-3 was detected in blood and tissue samples of both calves using BTV-specific real-time PCR. The presented findings demonstrate that there seems to be an association between transplacental BTV-3 infections and congenital malformations in calves, as previously reported for BTV-8 and -10.<\/jats:p>","DOI":"10.3390\/vetsci12080728","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T15:56:16Z","timestamp":1754409376000},"page":"728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Congenital Malformations of the Central Nervous System Caused by Bluetongue Virus Serotype 3 (BTV-3) in Two Calves"],"prefix":"10.3390","volume":"12","author":[{"given":"Phuong Do","family":"Duc","sequence":"first","affiliation":[{"name":"Clinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Reeh","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals, University of Veterinary Medicine Foundation, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"P\u00f6pperl","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-2067","authenticated-orcid":false,"given":"Tom","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-3922","authenticated-orcid":false,"given":"Natascha","family":"Gundling","sequence":"additional","affiliation":[{"name":"Clinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beineke","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9184-4134","authenticated-orcid":false,"given":"Peter","family":"Wohlsein","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8154-2642","authenticated-orcid":false,"given":"Martina","family":"Hoedemaker","sequence":"additional","affiliation":[{"name":"Clinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.prevetmed.2014.10.010","article-title":"Cost assessment of the movement restriction policy in France during the 2006 bluetongue virus episode (BTV-8)","volume":"117","author":"Tago","year":"2014","journal-title":"Prev. 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