{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:43:04Z","timestamp":1793911384443,"version":"4.8.0"},"reference-count":91,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Swine Inflammation and Necrosis Syndrome (SINS) is a simple and non-invasive animal-based health and welfare indicator that combines the clinical observation of bristle loss, swelling, redness, exudation, necrosis and haemorrhage in various parts of the body. It provides a point-of-care measure with direct intervention capability. Several studies from different countries demonstrate its considerable prevalence, particularly among newborn, suckling and weaned piglets. The syndrome has been demonstrated to be endogenous, as evidenced by clinical, pathohistological, clinical chemical, metabolomic, transcriptomic and genomic analysis. It has been established that the first and fourth weeks of life represent suitable time points for examination. However, longitudinal follow-up of individual animals has hitherto been lacking. In order to address this issue, a total of 1080 complete SINS examinations were conducted on 59 piglets at days 1 to 14, 19, 22, 26 and 41 of life. The findings substantiate the bimodal progression and evince a robust correlation between signs in disparate anatomical regions, including body temperature. Two peaks with significantly increased SINS signs were observed, the first around the fourth day of life and the second around day 26. The majority of indications of SINS in the second peak manifested prior to the initiation of the weaning process. The development of SINS signs in the piglets as a group followed a clear pattern. However, it was not feasible to predict the subsequent course of SINS based on individual animals. It is recommended that SINS, as an animal-based health and welfare indicator, be screened on days three to four and\/or in the fourth week of life. It is imperative that the day of life is specified with the greatest possible precision, given the propensity for considerable deviations to occur within a time frame of one to three days, especially during the initial week of life. The implementation of these findings has the potential to make a decisive contribution to improving inventory herd analyses and studies on SINS, thereby improving the welfare and health of piglets.<\/jats:p>","DOI":"10.3390\/vetsci12080752","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:53:27Z","timestamp":1755100407000},"page":"752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammation and Necrosis Syndrome in Young Piglets\u2014A Longitudinal Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Sabrina","family":"Becker","sequence":"first","affiliation":[{"name":"Justus-Liebig-University Giessen, Department of Veterinary Clinical Sciences, Clinic for Swine\u2014Herd Health Management and Molecular Diagnostics, Frankfurter Strasse 112, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hindenlang","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University Giessen, Department of Veterinary Clinical Sciences, Clinic for Swine\u2014Herd Health Management and Molecular Diagnostics, Frankfurter Strasse 112, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kuehling","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University Giessen, Department of Veterinary Clinical Sciences, Clinic for Swine\u2014Herd Health Management and Molecular Diagnostics, Frankfurter Strasse 112, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Lechner","sequence":"additional","affiliation":[{"name":"UEG Hohenlohe, Am Wasen 20, 91567 Herrieden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-0345","authenticated-orcid":false,"given":"Gerald","family":"Reiner","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University Giessen, Department of Veterinary Clinical Sciences, Clinic for Swine\u2014Herd Health Management and Molecular Diagnostics, Frankfurter Strasse 112, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Koenders-van Gog, K., Wijnands, T., Lechner, M., Reiner, G., and Fink-Gremmels, J. (2025). Screening of Piglets for Signs of Inflammation and Necrosis as Early Life Indicators of Animal Health and Welfare Hazards. Animals, 15.","DOI":"10.3390\/ani15030378"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"skad067","DOI":"10.1093\/jas\/skad067","article-title":"The genetic basis of swine inflammation and necrosis syndrome and its genetic association with post-weaning skin damage and production traits","volume":"101","author":"Leite","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_3","first-page":"301","article-title":"\u00c9valuation de la pr\u00e9valence du syndrome inflammatoire et n\u00e9crotique porcin dans les troupeaux fran\u00e7ais","volume":"56","author":"Fortune","year":"2024","journal-title":"Journ\u00e9es Rech. Porc."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Reiner, G., Kuehling, J., Loewenstein, F., Lechner, M., and Becker, S. (2021). Swine Inflammation and Necrosis Syndrome (SINS). Animals, 11.","DOI":"10.3390\/ani11061670"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.animal.2020.100078","article-title":"An in-depth diagnostic exploration of an inflammation and necrosis syndrome in a population of newborn piglets","volume":"15","author":"Kuehling","year":"2021","journal-title":"Animal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40813-021-00194-2","article-title":"The effects of boar on susceptibility to swine inflammation and necrosis syndrome in piglets","volume":"7","author":"Kuehling","year":"2021","journal-title":"Porc. Health Manag."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1017\/S1751731118003403","article-title":"Prevalence of an inflammation and necrosis syndrome in suckling piglets","volume":"13","author":"Reiner","year":"2019","journal-title":"Animal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40813-020-00170-2","article-title":"Swine Inflammation and Necrosis Syndrome is influenced by husbandry and quality of sow in suckling piglets, weaners and fattening pigs","volume":"6","author":"Reiner","year":"2020","journal-title":"Porc. Health Manag."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF01225491","article-title":"Histological and enzyme histochemical parameters for the age estimation of human skin wounds","volume":"107","author":"Betz","year":"1994","journal-title":"Int. J. Leg. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Loewenstein, F., Becker, S., Kuehling, J., Schrade, H., Lechner, M., Ringseis, R., Eder, K., Moritz, A., and Reiner, G. (2022). Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-021-03107-1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ringseis, R., Gessner, D.K., Loewenstein, F., Kuehling, J., Becker, S., Willems, H., Lechner, M., Eder, K., and Reiner, G. (2021). Swine Inflammation and Necrosis Syndrome Is Associated with Plasma Metabolites and Liver Transcriptome in Affected Piglets. Animals, 11.","DOI":"10.3390\/ani11030772"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., Kuehling, J., Lechner, M., Willems, H., Ringseis, R., and Reiner, G. (2025). Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome. BMC Vet. Res., 21.","DOI":"10.1186\/s12917-024-04469-y"},{"key":"ref_13","unstructured":"Ger\u00df, H. (2014). Anwendung der Infrarotthermographie zur nicht-invasiven Detektion fieberhafter Tiere in Schweinegruppen\u2014Einsch\u00e4tzung der Anwendbarkeit im Tierseuchenkrisenfall am Beispiel der Klassischen Schweinepest. [Ph.D. Thesis, Tier\u00e4rztliche Hochschule Hannover]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: Roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"Iba","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Li, H., Shan, W., Zhao, X., and Sun, W. (2025). Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26051965"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.5713\/ajas.2013.r.02","article-title":"Feed energy evaluation for growing pigs","volume":"26","author":"Kil","year":"2013","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.2527\/jas.2013-7002","article-title":"Estimation of the net energy requirements for maintenance in growing and finishing pigs","volume":"92","author":"Zhang","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kyriazakis, I., and Whittemore, C. (2006). Growth and body composition changes in pigs. Whittemore\u2019s Science and Practice of Pig Production, Blackwell Publishing Ltd.. [3rd ed.].","DOI":"10.1002\/9780470995624"},{"key":"ref_19","first-page":"422","article-title":"Untersuchungen zum Einfluss des Geburtsgewichtes von Saugferkeln auf nekrotische Ver\u00e4nderungen des Integuments und ihre m\u00f6gliche Bedeutung f\u00fcr den Kupierverzicht","volume":"96","author":"Meyer","year":"2024","journal-title":"Zuechtungskunde"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1113\/jphysiol.1972.sp009896","article-title":"The post-natal changes in minimal metabolic rate in the pig","volume":"224","author":"Studzinski","year":"1972","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12711-021-00609-2","article-title":"Selection for social genetic effects in purebreds increases growth in crossbreds","volume":"53","author":"Ask","year":"2021","journal-title":"Genet. Sel. Evol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.tim.2017.05.004","article-title":"Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health","volume":"25","author":"Gresse","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/1574-6941.12419","article-title":"Temporal changes and the effect of subtherapeutic concentrations of antibiotics in the gut microbiota of swine","volume":"90","author":"Holman","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aninu.2023.12.010","article-title":"Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets","volume":"17","author":"Han","year":"2024","journal-title":"Anim. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Gao, J., Yin, J., Xu, K., Li, T., and Yin, Y. (2019). What is the impact of diet on nutritional diarrhea associated with gut microbiota in weaning piglets: A system review. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/6916189"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejps.2010.09.019","article-title":"Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development","volume":"42","author":"Merchant","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10482-017-0836-4","article-title":"Dietary fibres modulate the composition and activity of butyrate-producing bacteria in the large intestine of suckling piglets","volume":"110","author":"Mu","year":"2017","journal-title":"Antonie Leeuwenhoek"},{"key":"ref_29","first-page":"225","article-title":"Endotoxemia in protein-energy malnutrition","volume":"7","author":"Klein","year":"1988","journal-title":"J. Pediatr. Gastroent Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ni.2608","article-title":"Control of pathogens and pathobionts by the gut microbiota","volume":"14","author":"Kamada","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Elinav","year":"2012","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/j.gastro.2022.09.007","article-title":"Inflammatory Bowel Disease Is Associated with Prediagnostic Perturbances in Metabolic Pathways","volume":"164","author":"Hua","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cgh.2013.07.001","article-title":"Intestinal permeability defects: Is it time to treat?","volume":"11","author":"Odenwald","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2077620","DOI":"10.1080\/21688370.2022.2077620","article-title":"Tight junctions: From molecules to gastrointestinal diseases","volume":"11","author":"Moonwiriyakit","year":"2023","journal-title":"Tissue Barriers"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3350\/cmh.2020.0086","article-title":"From intestinal dysbiosis to alcohol-associated liver disease","volume":"26","author":"Mendes","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pe\u00f1a-Dur\u00e1n, E., Garc\u00eda-Galindo, J.J., L\u00f3pez-Murillo, L.D., Huerta-Huerta, A., Balleza-Alejandri, L.R., Beltr\u00e1n-Ram\u00edrez, A., Anaya-Ambriz, E.J., and Su\u00e1rez-Rico, D.O. (2025). Microbiota and Inflammatory Markers: A Review of Their Interplay, Clinical Implications, and Metabolic Disorders. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041773"},{"key":"ref_38","first-page":"167","article-title":"Invited review: Bacterial lipopolysaccharides and innate immunity","volume":"7","author":"Alexander","year":"2001","journal-title":"J. Endotoxin Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1753425918769372","article-title":"LPS challenge increased intestinal permeability, dis-rupted mitochondrial function and triggered mitophagy of piglets","volume":"24","author":"Cao","year":"2018","journal-title":"Innate Immun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2174\/092986708784872393","article-title":"Human endotoxemia as a model of systemic inflammation","volume":"15","author":"Andreasen","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1017\/S0007114512001213","article-title":"Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia","volume":"108","author":"Moreira","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ijo.2016.26","article-title":"Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents","volume":"40","author":"Rainone","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.physbeh.2018.09.018","article-title":"Sick and grumpy: Changes in social behaviour after a controlled immune stimulation in group-housed gilts","volume":"198","author":"Munsterhjelm","year":"2019","journal-title":"Physiol. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nordgreen, J., Edwards, S.A., Boyle, L.A., Bolhuis, J.E., Veit, C., Sayyari, A., Marin, D.E., Dimitrov, I., Janczak, A.M., and Valros, A. (2020). A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00646"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Pearce, C.S., Mani, V., Boddicker, R.L., Johnson, J.S., Weber, T.E., Ross, J.W., Rhoads, R.P., Baumgard, L.H., and Gabler, N.K. (2013). Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070215"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2527\/jas.52339","article-title":"Heat stress reduces barrier function and alters intestinal metabolism in growing pigs","volume":"90","author":"Pearce","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ortega, A.D.S.V., and Szab\u00f3, C. (2021). Adverse Effects of Heat Stress on the Intestinal Integrity and Function of Pigs and the Mitigation Capacity of Dietary Antioxidants: A Review. Animals, 11.","DOI":"10.3390\/ani11041135"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"9851914","DOI":"10.1155\/2021\/9851914","article-title":"Mahmoud AM, Wilkinson FL, Sandhu MA, Lightfoot AP. The Interplay of Oxidative Stress and Inflammation: Mechanistic Insights and Therapeutic Potential of Antioxidants","volume":"2021","author":"Ayman","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00591-20","DOI":"10.1128\/mSystems.00591-20","article-title":"Consumption of Dietary Fiber from Different Sources during Pregnancy Alters Sow Gut Microbiota and Improves Performance and Reduces Inflammation in Sows and Piglets","volume":"6","author":"Liu","year":"2021","journal-title":"mSystems"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1093\/jas\/skz278","article-title":"Effects of dietary fiber sources during late gestation and lactation on sow performance, milk quality, and intestinal health in piglets1","volume":"97","author":"Shang","year":"2019","journal-title":"J. Anim. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.aninu.2020.10.001","article-title":"Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance","volume":"6","author":"Tian","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"ref_54","first-page":"e1247","article-title":"Heat stress increases insulin sensitivity in pigs","volume":"3","author":"Stoakes","year":"2015","journal-title":"Physiol. Repetit."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sahasrabudhe, N., Beukema, M., Tian, L., Troost, B., Scholte, J., Bruininx, E., Bruggeman, G., van den Berg, M., Scheurink, A., and Schols, H. (2018). Dietary fiber pectin directly blocks Toll-like receptor 2-1 and prevents doxorubicin-induced ileitis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00383"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Luu, M., Monning, H., and Visekruna, A. (2020). Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01225"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1017\/S1751731111000772","article-title":"Oxidative stress status of highly prolific sows during gestation and lactation","volume":"5","author":"Kim","year":"2011","journal-title":"Animal"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1530\/REP-09-0247","article-title":"Inflammatory pathways in female reproductive health and disease","volume":"138","author":"Jabbour","year":"2009","journal-title":"Reproduction"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Aponte-Mellado, A., Premkumar, B.J., Shaman, A., and Gupta, S. (2012). The effects of oxidative stress on female reproduction: A review. Reprod. Biol. Endocrinol., 10.","DOI":"10.1186\/1477-7827-10-49"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e01047-18","DOI":"10.1128\/AEM.01047-18","article-title":"Maternal soluble fiber diet during pregnancy changes the intestinal microbiota, improves growth performance, and reduces intestinal permeability in piglets","volume":"84","author":"Cheng","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1017\/S1751731118001684","article-title":"Follicular development of sows at weaning in relation to estimated breeding value for within-litter variation in piglet birth weight","volume":"13","author":"Costermans","year":"2019","journal-title":"Animal"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sawicki, C.M., Livingston, K.A., Obin, M., Roberts, S.B., Chung, M., and McKeown, N.M. (2017). Dietary fiber and the human gut microbiota: Application of evidence mapping methodology. Nutrients, 9.","DOI":"10.3390\/nu9020125"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.3945\/jn.115.217406","article-title":"Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets","volume":"145","author":"Huang","year":"2015","journal-title":"J. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41579-018-0036-x","article-title":"Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier","volume":"16","author":"Martens","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00335-023-10011-6","article-title":"GWAS reveals genomic associations with swine inflammation and necrosis syndrome","volume":"34","author":"Gerhards","year":"2023","journal-title":"Mamm. Genome"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., K\u00fchling, J., Mickan, J., Lechner, M., Willems, H., and Reiner, G. (2025). Fine Mapping Identifies Candidate Genes Associated with Swine Inflammation and Necrosis Syndrome. Vet. Sci., 12.","DOI":"10.3390\/vetsci12050508"},{"key":"ref_67","unstructured":"Wick-Urban, B. (2025, August 01). St\u00f6rfall in der Chemiefabrik. Available online: https:\/\/www.pharmazeutische-zeitung.de\/ausgabe-112011\/stoerfall-in-der-chemiefabrik\/."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1007\/s10620-006-9158-5","article-title":"The Microvacular Thrombi of Colonic Tissue in Ulcerative Colitis","volume":"52","author":"He","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40813-016-0041-2","article-title":"Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health","volume":"2","author":"Pierron","year":"2016","journal-title":"Porc. Health Manag."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2004.04.023","article-title":"Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: Unravelling a paradoxon","volume":"153","author":"Pestka","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2009.03.003","article-title":"The food contaminant deoxynivalenol decreases intestinal barrier permeability and reduces claudin expression","volume":"237","author":"Pinton","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fct.2013.02.050","article-title":"Interactions between the Fusarium toxin deoxynivaleno and lipopolysaccharides on the in vivo protein synthesis of acute phase proteins, cytokines and metabolic activity of peripheral blood mononuclear cells in pigs","volume":"57","author":"Kullik","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_73","first-page":"276","article-title":"DON and LPS alter epithelial proliferation and spatial distribution of apical junction proteins along the small intestinal axis","volume":"90","author":"Klunker","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12550-014-0201-7","article-title":"Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig","volume":"30","author":"Valenta","year":"2014","journal-title":"Mycotox Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.112.5.783","article-title":"On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal","volume":"112","author":"Ravin","year":"1960","journal-title":"J. Exp. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0300-483X(01)00523-6","article-title":"Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents","volume":"169","author":"Ganey","year":"2001","journal-title":"Toxicology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0007-1935(86)90032-1","article-title":"Pathophysiological effects of endotoxin infusion in young piglets","volume":"142","author":"Schrauwen","year":"1986","journal-title":"Br. Vet. J."},{"key":"ref_78","first-page":"269","article-title":"Mise en evidence du transfer des endotoxines de la truie vers sa port\u00e9e dans le context du syndrome de dysgalactie post-partum","volume":"45","author":"Guillou","year":"2013","journal-title":"J. Rech. Porc."},{"key":"ref_79","first-page":"396","article-title":"Long-term effect of fusariotoxins on the reproduction performance of sows testing the effectiveness of detoxifying feed additives 700","volume":"10","author":"Jadamus","year":"2002","journal-title":"FEED Mag."},{"key":"ref_80","unstructured":"Busch, M.E., Jensen, I.M., and Korsgaard, J. (2010, January 18\u201321). Development and consequences of ear necrosis in a weaner herd and two growingfinishing herds. Proceedings of the 21st International Pig Veterinary Society Congress, Vancouver, BC, Canada."},{"key":"ref_81","first-page":"147","article-title":"The role of intestinal endotoxins in gastrointestinal and liver diseases","volume":"272","author":"Nolan","year":"1988","journal-title":"Prog. Clin. Biol. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0528.2002.017408.x","article-title":"Local control of the immune response in the liver","volume":"174","author":"Knolle","year":"2000","journal-title":"Immunol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13028-015-0094-2","article-title":"Infrared skin temperature measurements for monitoring health in pigs: A review","volume":"57","author":"Soerensen","year":"2015","journal-title":"Acta Vet. Scand."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Prado, J., Pereira, A.M.F., Wang, D., Villanueva-Garc\u00eda, D., Dom\u00ednguez-Oliva, A., Mora-Medina, P., Hern\u00e1ndez-Avalos, I., Mart\u00ednez-Burnes, J., Casas-Alvarado, A., and Olmos-Hern\u00e1ndez, A. (2022). Thermoregulation mechanisms and perspectives for validating thermal windows in pigs with hypothermia and hyperthermia: An overview. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.1023294"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Falotico, J.M., Shinozaki, K., Saeki, K., and Becker, L.B. (2020). Advances in the Approaches Using Peripheral Perfusion for Monitoring Hemodynamic Status. Front. Med., 7.","DOI":"10.3389\/fmed.2020.614326"},{"key":"ref_86","unstructured":"Granger, D.N., and Senchenkova, E. (2025, August 01). Inflammation and the Microcirculation. San Rafael (CA): Morgan and Claypool Life Sciences, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK53373\/."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/0007-1935(86)90044-8","article-title":"The effect of floor type in farrowing pens on pig injury. I. Leg and teat damage of suckling piglets","volume":"142","author":"Furniss","year":"1986","journal-title":"Br. Vet. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0002-9610(02)00812-7","article-title":"Mucosal and enterocyte IL-6 production during sepsis and endotoxemia--role of transcription factors and regulation by the stress response","volume":"183","author":"Pritts","year":"2002","journal-title":"Am. J. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-0716-1138-8_6","article-title":"Longitudinal Studies 1: Determinants of Risk","volume":"2249","author":"Murphy","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbr.2017.08.029","article-title":"Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL\/6J mice","volume":"336","author":"Bodden","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Cnops, V., Iyer, V.R., Parathy, N., Wong, P., and Dawe, G.S. (2022). Test, rinse, repeat: A review of carryover effects in rodent behavioral assays. Neurosci. Biobehav. Rev., 135.","DOI":"10.1016\/j.neubiorev.2022.104560"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/8\/752\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:26:21Z","timestamp":1760034381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/8\/752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":91,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["vetsci12080752"],"URL":"https:\/\/doi.org\/10.3390\/vetsci12080752","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]}}}