{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:54:02Z","timestamp":1784199242814,"version":"3.55.0"},"reference-count":62,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pernambuco Research Foundation","award":["APQ-0895-5.05\/14"],"award-info":[{"award-number":["APQ-0895-5.05\/14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The aim of this study was to evaluate the effect of different water restrictions on the thermoregulation and blood hematological and metabolite parameters of crossbred Santa In\u00eas ewes in a semi-arid climate. Thirty-two ewes were subjected to four water supply levels (100%, 80%, 60%, and 40%), in a completely randomized design with eight replications. The confinement period lasted 77 days, with 14 days allocated for adaptation. Respiratory rate, heart rate, and rectal temperature exhibited a quadratic response. There was an increase in red blood cells and urea. The enzyme alanine aminotransferase decreased linearly with water restriction. Urinary creatinine decreased along with water supply. Regarding urine color characteristics, all groups showed different colors, ranging from clear to cloudy. For the chemical characteristics of urine, a quadratic effect was observed for pH, with the highest value (8.75) at 60%. An increase was observed in total urine proteins and urobilinogen. Crossbred Santa In\u00eas ewes in a semi-arid climate exhibit physiological adaptations to water supply reduction up to 40%. Following an 80% reduction in water supply, animals exhibit mild dehydration, characterized by increased serum urea levels and decreased alanine aminotransferase activity.<\/jats:p>","DOI":"10.3390\/vetsci12090790","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T13:47:49Z","timestamp":1755870469000},"page":"790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physiological and Metabolic Responses to Water Restriction in Ewes Under Semi-Arid Conditions"],"prefix":"10.3390","volume":"12","author":[{"given":"Claudenilde de Jesus Pinheiro","family":"Costa","sequence":"first","affiliation":[{"name":"Universidade Federal do Agreste de Pernambuco, Garanhuns 55292-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gherman Garcia Leal de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Embrapa Semi-\u00c1rido, Petrolina 56302-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-6795","authenticated-orcid":false,"given":"Andr\u00e9 Luiz Rodrigues","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade Federal do Agreste de Pernambuco, Garanhuns 55292-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-394X","authenticated-orcid":false,"given":"Alber\u00edcio Pereira","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal do Agreste de Pernambuco, Garanhuns 55292-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Helena Nogueira","family":"Turco","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena Tavares de","family":"Matos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego C\u00e9sar Nunes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleyton de Almeida","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco, Petrolina 56300-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1341-1602","authenticated-orcid":false,"given":"Roberta de Lima","family":"Valen\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade Federal do Espirito Santo, Alegre 29500-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-4935","authenticated-orcid":false,"given":"Thieres George Freire da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural de Pernambuco, Serra Talhada 56909-535, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9027-3210","authenticated-orcid":false,"given":"Fleming Sena","family":"Campos","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Sudoeste da Bahia, Itapetinga 45700-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-1825","authenticated-orcid":false,"given":"Glayciane Costa","family":"Gois","sequence":"additional","affiliation":[{"name":"Universidade Federal do Maranh\u00e3o, Chapadinha 65500-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtherbio.2016.05.001","article-title":"Effect of multiple stress factors (thermal, nutritional and pregnancy type) on adaptive capability of native ewes under semi-arid environment","volume":"59","author":"Marques","year":"2016","journal-title":"J. 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