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Conventional antibiotic treatments proved ineffective. To investigate the etiology of the disease, brain and liver specimens were collected for diagnostic analysis. An Escherichia coli (E. coli) isolate, designated strain HZDC01, was obtained from cerebral tissues, and whole-genome sequencing was performed for genomic characterization. Genomic analysis revealed that the chromosomal DNA harbors numerous resistance genes, conferring multidrug resistance through complex mechanisms. Furthermore, a p0111-type plasmid carrying the blaCTX-M-55 gene and an IncX1-type plasmid harboring rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, blaTEM-1B, and floR genes were identified. These plasmids carry numerous mobile genetic elements that can disseminate via horizontal gene transfer, thereby amplifying the risk of resistance-gene spread within bacterial populations. Additionally, the ibeB and ibeC genes, which encode proteins involved in the invasion of brain microvascular endothelial cells, were identified. These genes may facilitate E. coli penetration of the blood\u2013brain barrier, potentially leading to meningitis and posing a life-threatening risk to the host. This is the first report of the isolation and characterization of extended-spectrum beta-lactamase E. coli from the brain of an ostrich with paralysis. The findings provide valuable genomic insights into the antimicrobial resistance profiles and pathogenic mechanisms of ostrich-derived E. coli isolates.<\/jats:p>","DOI":"10.3390\/vetsci12090793","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T15:57:47Z","timestamp":1755878267000},"page":"793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich"],"prefix":"10.3390","volume":"12","author":[{"given":"Jing","family":"Hu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, Nanning 530004, China"},{"name":"Guangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning 530001, China"},{"name":"Key Laboratory of China 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(2023). Extended-Spectrum beta-Lactamases (ESBL): Challenges and Opportunities. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112937"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mendonca, J., Guedes, C., Silva, C., Sa, S., Oliveira, M., Accioly, G., Baylina, P., Barata, P., Pereira, C., and Fernandes, R. (2022). New CTX-M Group Conferring beta-Lactam Resistance: A Compendium of Phylogenetic Insights from Biochemical, Molecular, and Structural Biology. Biology, 11.","DOI":"10.3390\/biology11020256"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-1347","DOI":"10.12688\/f1000research.14822.1","article-title":"Treatment of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBLs) infections: What have we learned until now?","volume":"7","author":"Pana","year":"2018","journal-title":"F1000Research"},{"key":"ref_8","first-page":"dlab92","article-title":"Extended-spectrum beta-lactamases: An update on their characteristics, epidemiology and detection","volume":"3","author":"Castanheira","year":"2021","journal-title":"JAC-Antimicrob. Resist."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101036","DOI":"10.1016\/j.drup.2023.101036","article-title":"Global spread characteristics of CTX-M-type extended-spectrum beta-lactamases: A genomic epidemiology analysis","volume":"73","author":"Yu","year":"2024","journal-title":"Drug Resist. Update"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pearce, R., Pirolo, M., Goecke, N.B., Toppi, V., Good, L., Guitian, J., and Guardabassi, L. (2025). Imported seafood is a reservoir of Enterobacteriaceae carrying CTX-M-encoding genes of high clinical relevance. Int. J. Food Microbiol., 430.","DOI":"10.1016\/j.ijfoodmicro.2025.111063"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/s41467-024-45757-3","article-title":"Phage-plasmids promote recombination and emergence of phages and plasmids","volume":"15","author":"Pfeifer","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ben, H.A., Haendiges, J., Zormati, S., Guermazi, S., Gdoura, R., Gonzalez-Escalona, N., and Siala, M. (2021). Virulence and resistance genes profiles and clonal relationships of non-typhoidal food-borne Salmonella strains isolated in Tunisia by whole genome sequencing. Int. J. Food Microbiol., 337.","DOI":"10.1016\/j.ijfoodmicro.2020.108941"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101929","DOI":"10.1016\/j.psj.2022.101929","article-title":"Emergence and genomic analysis of a novel ostrich-origin GPV-related parvovirus in China","volume":"101","author":"Zhao","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Schubert, M., Lindgreen, S., and Orlando, L. (2016). AdapterRemoval v2: Rapid adapter trimming, identification, and read merging. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-1900-2"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13742-015-0069-2","article-title":"Erratum: SOAPdenovo2: An empirically improved memory-efficient short-read de novo assembler","volume":"4","author":"Luo","year":"2015","journal-title":"Gigascience"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nmeth.4035","article-title":"Phased diploid genome assembly with single-molecule real-time sequencing","volume":"13","author":"Chin","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1101\/gr.215087.116","article-title":"Canu: Scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation","volume":"27","author":"Koren","year":"2017","journal-title":"Genome Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Walker, B.J., Abeel, T., Shea, T., Priest, M., Abouelliel, A., Sakthikumar, S., Cuomo, C.A., Zeng, Q., Wortman, J., and Young, S.K. (2014). Pilon: An integrated tool for comprehensive microbial variant detection and genome assembly improvement. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112963"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Beghain, J., Bridier-Nahmias, A., Le Nagard, H., Denamur, E., and Clermont, O. (2018). ClermonTyping: An easy-to-use and accurate in silico method for Escherichia genus strain phylotyping. Microb. Genom., 4.","DOI":"10.1099\/mgen.0.000192"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkac920","article-title":"CARD 2023: Expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gki008","article-title":"VFDB: A reference database for bacterial virulence factors","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Brettin, T., Davis, J.J., Disz, T., Edwards, R.A., Gerdes, S., Olsen, G.J., Olson, R., Overbeek, R., Parrello, B., and Pusch, G.D. (2015). RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes. Sci. Rep., 5.","DOI":"10.1038\/srep08365"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"W484","DOI":"10.1093\/nar\/gkad326","article-title":"Proksee: In-depth characterization and visualization of bacterial genomes","volume":"51","author":"Grant","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_24","first-page":"619832","article-title":"Blast2GO: A comprehensive suite for functional analysis in plant genomics","volume":"2008","author":"Conesa","year":"2008","journal-title":"Int. J. Plant Genom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","article-title":"Easyfig: A genome comparison visualizer","volume":"27","author":"Sullivan","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s10482-017-0844-4","article-title":"A large-scale evaluation of algorithms to calculate average nucleotide identity","volume":"110","author":"Yoon","year":"2017","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"W182","DOI":"10.1093\/nar\/gkm321","article-title":"KAAS: An automatic genome annotation and pathway reconstruction server","volume":"35","author":"Moriya","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_28","unstructured":"(2024). Performance Standards for Antimicrobial Susceptibility Testing (Standard No. M100)."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Salleh, M.Z., Nik, Z.N., Hajissa, K., Ilias, M.I., and Deris, Z.Z. (2022). Prevalence of Multidrug-Resistant Diarrheagenic Escherichia coli in Asia: A Systematic Review and Meta-Analysis. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101333"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81564-0","article-title":"E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy","volume":"100","author":"Wallace","year":"2000","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1128\/IAI.68.7.4363-4367.2000","article-title":"Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages","volume":"68","author":"Lai","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1099\/mic.0.26877-0","article-title":"Properties of haemolysin E (HlyE) from a pathogenic Escherichia coli avian isolate and studies of HlyE export","volume":"150","author":"Wyborn","year":"2004","journal-title":"Microbiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1203\/00006450-200205000-00003","article-title":"Role of OmpA and IbeB in Escherichia coli K1 invasion of brain microvascular endothelial cells in vitro and in vivo","volume":"51","author":"Wang","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tsai, Y., Ienes, L.J., Alvarez, N.S., and Logue, C.M. (2025). Whole-genome analysis of five Escherichia coli strains isolated from focal duodenal necrosis in laying hens reveals genetic similarities to the E. coli O25:H4 ST131 strain. Microbiol. Spectr., 13.","DOI":"10.1128\/spectrum.02110-24"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Renzhammer, R., Schwarz, L., Cabal, R.A., Ruppitsch, W., Fuchs, A., Simetzberger, E., Ladinig, A., and Loncaric, I. (2024). Detection of mcr-1-1 Positive Enteropathogenic Escherichia coli Isolates Associated with Post-Weaning Diarrhoea in an Organic Piglet-Producing Farm in Austria. Microorganisms, 12.","DOI":"10.3390\/microorganisms12020244"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s43440-020-00160-9","article-title":"Efflux pump inhibitors: New updates","volume":"73","author":"AlMatar","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.resmic.2018.05.005","article-title":"Molecular mechanisms of AcrB-mediated multidrug export","volume":"169","author":"Zwama","year":"2018","journal-title":"Res. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/rvsc.2001.0537","article-title":"The multiple antibiotic resistance (mar) locus and its significance","volume":"72","author":"Randall","year":"2002","journal-title":"Res. Vet. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1093\/emboj\/cdg252","article-title":"A reducing system of the superoxide sensor SoxR in Escherichia coli","volume":"22","author":"Koo","year":"2003","journal-title":"EMBO J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/jac\/dkv105","article-title":"A novel alanine to serine substitution mutation in SoxS induces overexpression of efflux pumps and contributes to multidrug resistance in clinical Escherichia coli isolates","volume":"70","author":"Aly","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Li, H., Wang, Q., Wang, R., Zhang, Y., Wang, X., and Wang, H. (2017). Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine, 96.","DOI":"10.1097\/MD.0000000000007188"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1128\/AAC.49.7.2746-2752.2005","article-title":"Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates","volume":"49","author":"Koutsolioutsou","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yadav, S., Singh, A.K., Agrahari, A.K., Pandey, A.K., Gupta, M.K., Chakravortty, D., Tiwari, V.K., and Prakash, P. (2021). Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance among Klebsiella pneumoniae by Targeting Its Carbapenemases and the AcrAB-TolC Efflux System. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040388"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Onishi, R., Shigemura, K., Osawa, K., Yang, Y.M., Maeda, K., Fang, S.B., Sung, S.Y., Onuma, K., Uda, A., and Miyara, T. (2021). The Antimicrobial Resistance Characteristics of Imipenem-Non-Susceptible, Imipenemase-6-Producing Escherichia coli. Antibiotics, 11.","DOI":"10.3390\/antibiotics11010032"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1128\/AAC.49.10.4390-4392.2005","article-title":"Contribution of mutation at amino acid 45 of AcrR to acrB expression and ciprofloxacin resistance in clinical and veterinary Escherichia coli isolates","volume":"49","author":"Webber","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1128\/AAC.41.10.2067","article-title":"Regulation of chromosomally mediated multiple antibiotic resistance: The mar regulon","volume":"41","author":"Alekshun","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1046\/j.1365-2958.2000.01802.x","article-title":"Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding","volume":"35","author":"Alekshun","year":"2000","journal-title":"Mol. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-4781(98)00126-2","article-title":"DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities","volume":"1400","author":"Levine","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kivata, M.W., Mbuchi, M., Eyase, F.L., Bulimo, W.D., Kyanya, C.K., Oundo, V., Muriithi, S.W., Andagalu, B., Mbinda, W.M., and Soge, O.O. (2019). gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1439-1"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/IDR.S147581","article-title":"Le DV Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in Vietnam","volume":"11","author":"Nguyen","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1128\/AAC.01365-16","article-title":"Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata)","volume":"60","author":"Yang","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tang, B., Chang, J., Cao, L., Luo, Q., Xu, H., Lyu, W., Qian, M., Ji, X., Zhang, Q., and Xia, X. (2019). Characterization of an NDM-5 carbapenemase-producing Escherichia coli ST156 isolate from a poultry farm in Zhejiang, China. Bmc Microbiol., 19.","DOI":"10.1186\/s12866-019-1454-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"104499","DOI":"10.1016\/j.meegid.2020.104499","article-title":"Genomic features of an Escherichia coli ST156 strain harboring chromosome-located mcr-1 and plasmid-mediated bla(NDM-5)","volume":"85","author":"Lin","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.tim.2018.02.006","article-title":"Towards Understanding MCR-like Colistin Resistance","volume":"26","author":"Sun","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Shi, J., Zhu, H., Liu, C., Xie, H., Li, C., Cao, X., and Shen, H. (2022). Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1105401"},{"key":"ref_57","first-page":"DL3","article-title":"Challenges, Issues and Warnings from CLSI and EUCAST Working Group on Polymyxin Susceptibility Testing","volume":"11","author":"Bakthavatchalam","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ijantimicag.2013.08.009","article-title":"Transposition of ISEcp1 modulates blaCTX-M-55-mediated Shigella flexneri resistance to cefalothin","volume":"42","author":"Wang","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1099\/jmm.0.039487-0","article-title":"Chromosomal blaCTX-M-(1)(5) associated with ISEcp1 in Proteus mirabilis and Morganella morganii isolated at the Military Hospital of Tunis, Tunisia","volume":"61","author":"Mahrouki","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Wang, M., Jiang, L., Wei, J., Zhu, H., Zhang, J., Liu, Z., Zhang, W., He, X., Liu, Y., and Li, R. (2022). Similarities of P1-Like Phage Plasmids and Their Role in the Dissemination of bla(CTX-M-55). Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.01410-22"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Hansen, L.H., Bentzon-Tilia, M., Bentzon-Tilia, S., Norman, A., Rafty, L., and Sorensen, S.J. (2011). Design and synthesis of a quintessential self-transmissible IncX1 plasmid, pX1.0. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019912"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhao, H., Chen, W., Xu, X., Zhou, X., and Shi, C. (2018). Transmissible ST3-IncHI2 Plasmids Are Predominant Carriers of Diverse Complex IS26-Class 1 Integron Arrangements in Multidrug-Resistant Salmonella. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.02492"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jiang, H., Cheng, H., Liang, Y., Yu, S., Yu, T., Fang, J., and Zhu, C. (2019). Diverse Mobile Genetic Elements and Conjugal Transferability of Sulfonamide Resistance Genes (sul1, sul2, and sul3) in Escherichia coli Isolates from Penaeus vannamei and Pork from Large Markets in Zhejiang, China. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01787"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Lallement, C., Pasternak, C., Ploy, M.C., and Jove, T. (2018). The Role of ISCR1-Borne P(OUT) Promoters in the Expression of Antibiotic Resistance Genes. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.02579"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Liu, S., Yang, X., Li, R., Wang, S., Han, Z., Yang, M., and Zhang, Y. (2024). IS6 family insertion sequences promote optrA dissemination between plasmids varying in transfer abilities. Appl. Microbiol. Biot., 108.","DOI":"10.1007\/s00253-023-12858-w"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/03079459408418987","article-title":"Botulism in ostriches (Struthio camelus)","volume":"23","author":"Allwright","year":"1994","journal-title":"Avian Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Yuan, K., Wang, D., Luan, Q., Sun, J., Gao, Q., Jiang, Z., Wang, S., Han, Y., Qu, X., and Cui, Y. (2020). Whole Genome Characterization and Genetic Evolution Analysis of a New Ostrich Parvovirus. Viruses, 12.","DOI":"10.3390\/v12030334"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1128\/iai.63.11.4470-4475.1995","article-title":"Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: Molecular cloning and characterization of invasion gene ibe10","volume":"63","author":"Huang","year":"1995","journal-title":"Infect. Immun."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wang, P., Meng, X., Li, J., Chen, Y., Zhang, D., Zhong, H., Xia, P., Cui, L., Zhu, G., and Wang, H. (2020). Transcriptome profiling of avian pathogenic Escherichia coli and the mouse microvascular endothelial cell line bEnd.3 during interaction. PeerJ, 8.","DOI":"10.7717\/peerj.9172"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/IAI.00953-15","article-title":"Bioluminescent imaging reveals novel patterns of colonization and invasion in systemic Escherichia coli K1 experimental infection in the neonatal rat","volume":"83","author":"Witcomb","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2174\/138161209788682325","article-title":"The roles of antimicrobial peptides in innate host defense","volume":"15","author":"Diamond","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xie, F., Wang, Y., Li, G., Liu, S., Cui, N., Liu, S., Langford, P.R., and Wang, C. (2017). The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of Actinobacillus pleuropneumoniae. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00811"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.micres.2018.07.005","article-title":"The role of two-component regulatory system in beta-lactam antibiotics resistance","volume":"215","author":"Lingzhi","year":"2018","journal-title":"Microbiol. Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Tiwari, S., Jamal, S.B., Hassan, S.S., Carvalho, P., Almeida, S., Barh, D., Ghosh, P., Silva, A., Castro, T., and Azevedo, V. (2017). Two-Component Signal Transduction Systems of Pathogenic Bacteria as Targets for Antimicrobial Therapy: An Overview. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.01878"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Mensa, B., Polizzi, N.F., Molnar, K.S., Natale, A.M., Lemmin, T., and DeGrado, W.F. (2021). Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. eLife, 10.","DOI":"10.7554\/eLife.73336"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1515\/pjvs-2016-0005","article-title":"Modulation of virulence genes by the two-component system PhoP-PhoQ in avian pathogenic Escherichia coli","volume":"19","author":"Tu","year":"2016","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/03079457.2019.1605147","article-title":"The role of the phoP transcriptional regulator on biofilm formation of avian pathogenic Escherichia coli","volume":"48","author":"Yin","year":"2019","journal-title":"Avian Pathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1128\/IAI.01949-05","article-title":"Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis","volume":"74","author":"Meli","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1128\/AAC.17.4.526","article-title":"Cefoxitin penetration into cerebrospinal fluid in patients with purulent meningitis","volume":"17","author":"Galvao","year":"1980","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jgar.2022.01.015","article-title":"Genetic context diversity of plasmid-borne blaCTX-M-55 in Escherichia coli isolated from waterfowl","volume":"28","author":"Zhang","year":"2022","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Bai, H., Liao, Y., Lu, J., Pei, Z., Yin, Y., Ma, C., Chen, Z., Li, C., Li, J., and Gong, Y. (2025). In vitro antibacterial efficacy of a novel chicken-derived Bacillus subtilis GX15 strain and its protective mechanisms in mice challenged by Salmonella enterica serovar typhymurium. BMC Microbiol., 25.","DOI":"10.1186\/s12866-025-04107-z"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Hao, S., Shi, W., Chen, L., Kong, T., Wang, B., Chen, S., and Guo, X. (2024). CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1390934"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wu, W., Mis, S.K., and Chen, J. (2024). Ellagitannin content and anti-enterohemorrhagic Escherichia coli activity of aqueous extracts derived from commercial pomegranate products. Heliyon, 10.","DOI":"10.1016\/j.heliyon.2024.e29700"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Wang, L., Tan, Y., Liao, Y., Li, L., Han, K., Bai, H., Cao, Y., Li, J., Gong, Y., and Wang, X. (2022). Isolation, Characterization and Whole Genome Analysis of an Avian Pathogenic Escherichia coli Phage vB_EcoS_GN06. Vet. Sci., 9.","DOI":"10.21203\/rs.3.rs-1702741\/v1"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/9\/793\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:34:23Z","timestamp":1760034863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/9\/793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":84,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["vetsci12090793"],"URL":"https:\/\/doi.org\/10.3390\/vetsci12090793","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}