{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:23:34Z","timestamp":1785252214392,"version":"3.55.0"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>This study investigated the effects of low-dose 1cp-LSD, a prodrug of LSD, on canine anxiety, while exploring the influence of owner psychopathology on treatment outcomes. Seven dogs exhibiting anxiety-related behaviors were recruited and received 2.5, 5, or 10 \u00b5g of 1cp-LSD orally every three days for 30 days. One additional dog, which did not meet clinical criteria for anxiety but whose owner perceived it as anxious, received a placebo (saccharin) as an observational case. Anxiety levels were assessed using validated scales at baseline, post-treatment, and one month after treatment cessation. Owners\u2019 neuroticism and psychopathological dimensions were evaluated using the IPIP and SA-45 scales. Linear regression analyses examined associations between anxiety reduction, administered dose, and owner psychological traits. A significant reduction in separation anxiety scores was observed post-treatment (mean: 11.3 \u00b1 3.0, p = 0.023). Higher 1cp-LSD doses correlated with greater anxiety reduction (B = \u22121.15, 95% CI = [\u22122.29, \u22120.003], p = 0.050). Additionally, higher owner psychoticism scores were associated with smaller improvements in canine anxiety (p = 0.035). Anxiety levels remained low one month after treatment, with significant associations between canine anxiety and the owners\u2019 hostility, interpersonal sensitivity, and paranoid ideation. These findings support the potential role of low-dose serotonergic psychedelics in managing canine anxiety and suggest an association between caregiver psychological traits and treatment outcomes. The sustained reduction in anxiety behaviors also suggests a meaningful and lasting improvement in animal welfare. However, significant results should be interpreted cautiously due to the small sample size. Further blinded, controlled studies are needed to validate these preliminary observations and assess broader applications in veterinary behavioral medicine.<\/jats:p>","DOI":"10.3390\/vetsci12090872","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:27:12Z","timestamp":1757500032000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7879-7578","authenticated-orcid":false,"given":"Elisa","family":"Hern\u00e1ndez-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Health Sciences Faculty, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"},{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-7881","authenticated-orcid":false,"given":"Jaime","family":"Rojas-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Health Sciences Faculty, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"},{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"},{"name":"Asociaci\u00f3n Canaria para el Desarrollo de la Salud a Trav\u00e9s de la Atenci\u00f3n, 35007 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0266-9560","authenticated-orcid":false,"given":"Lucas F.","family":"Borkel","sequence":"additional","affiliation":[{"name":"Health Sciences Faculty, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"},{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-2121","authenticated-orcid":false,"given":"Domingo J.","family":"Quintana-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"},{"name":"Faculty of Psychology, Universidad del Atl\u00e1ntico Medio, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-1719","authenticated-orcid":false,"given":"Tob\u00edas","family":"Fern\u00e1ndez-Borkel","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"},{"name":"Center for MR Research, University Children\u2019s Hospital Zurich, 8032 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-0316","authenticated-orcid":false,"given":"Luis Alberto","family":"Henr\u00edquez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, 35412 Arucas, Spain"},{"name":"Unit of Toxicology, Clinical Science Department, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kalinin, V.V. 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