{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:21:09Z","timestamp":1770974469628,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Study on Key Technologies for Conservation of Wild Giant Panda Populations and Its Habitats within Giant Panda National Park System","award":["CGF2024001"],"award-info":[{"award-number":["CGF2024001"]}]},{"name":"Study on Key Technologies for Conservation of Wild Giant Panda Populations and Its Habitats within Giant Panda National Park System","award":["2018YFD0500900"],"award-info":[{"award-number":["2018YFD0500900"]}]},{"name":"Study on Key Technologies for Conservation of Wild Giant Panda Populations and Its Habitats within Giant Panda National Park System","award":["2016YFD0501009"],"award-info":[{"award-number":["2016YFD0501009"]}]},{"name":"National Key Research and Development Program of China","award":["CGF2024001"],"award-info":[{"award-number":["CGF2024001"]}]},{"name":"National Key Research and Development Program of China","award":["2018YFD0500900"],"award-info":[{"award-number":["2018YFD0500900"]}]},{"name":"National Key Research and Development Program of China","award":["2016YFD0501009"],"award-info":[{"award-number":["2016YFD0501009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>(1) Background: Chronic enteropathy (CE) in canines is associated with persistent microbiome dysbiosis, and conventional therapies (e.g., special diets, antimicrobials, and immunosuppressive drugs) are sometimes ineffective. Currently, fecal microbiota transplantation (FMT) has proven successful in treating CE in canines via invasive methods (e.g., enemas or endoscopy) or via oral frozen liquid capsules, which must be stored at \u221280 \u00b0C. However, due to the invasiveness of the administration methods and the storage constraints of the liquid capsules, FMT is not widely used in veterinary clinical practice. (2) Methods: The case of a four-year-old Siberian Husky with a three-year history of CE following canine parvovirus infection received lyophilized FMT capsules for thirty days. Stool samples were collected for metagenomic sequencing and quantification of fecal short-chain fatty acids (SCFAs), both pre- and post-FMT. Blood samples were analyzed using complete blood count (CBC) and biochemical testing. Ultrasound was used to assess the wall thickness of the stomach, duodenum, jejunum, and colon. (3) Results: Post-FMT, improvements in clinical outcomes were observed: fecal scores improved from 6 (unformed stools with mucus) to 2 (formed stool), and body weight increased by 8.3% (from 24.2 kg to 26.2 kg). Abnormal CBC and biochemical parameters were restored to reference ranges, including hematocrit (from 60.6% to 55.7%), hemoglobin (from 208 g\/L to 190 g\/L), creatinine (from 167 \u03bcmol\/L to 121 \u03bcmol\/L), and urea (from 11.9 mmol\/L to 7.1 mmol\/L). Ultrasound results showed that colonic wall thickness decreased from 0.23 \u00b1 0.03 cm (pathological) to 0.18 \u00b1 0.01 cm (physiological). Metagenomic analysis revealed that microbial richness (operational taxonomic units (OTUs) from 151 to 183) and diversity (Shannon and Simpson indices from 3.16 to 4.8 and from 0.87 to 0.94, respectively) all increased. The microbiota composition of the recipient exhibited a decline in the relative abundance of Firmicutes, falling from 99.84% to 35.62%, concomitant with an increase in Actinobacteria (from 0.08% to 4.78%), indicating a convergence toward a donor-like profile. Fecal SCFAs analysis revealed a 251.4% increase in propionate (from 0.0833 to 0.2929 mg\/g) and elevated acetate (from 0.4425 to 0.4676 mg\/g). These changes are functionally linked to enriched propanoate metabolism (Z = 0.89) in KEGG pathways. (4) Conclusions: Oral lyophilized FMT capsules resolved clinical signs of CE, enhanced microbial diversity and richness, and restored donor-like abundances of gut microbiota, particularly SCFA-producing taxa. Microbial restructuring increased microbial metabolite output, notably SCFA concentrations, and enriched functional metabolic pathways. Importantly, lyophilized FMT overcomes storage limitations and administration barriers, demonstrating its high clinical viability for treating canine CE.<\/jats:p>","DOI":"10.3390\/vetsci12090909","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:45:46Z","timestamp":1758206746000},"page":"909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects and Microbiota Changes Following Oral Lyophilized Fecal Microbiota Transplantation Capsules in Canine with Chronic Enteropathy After Parvovirus Infection: Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Siyu","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baihui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sichuan Anaerobic Biotechnology Co., Ltd., Chengdu 610200, China"},{"name":"Chengdu LifeMicro Technology Co., Ltd., Chengdu 610213, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Anaerobic Biotechnology Co., Ltd., Chengdu 610200, China"},{"name":"Chengdu LifeMicro Technology Co., Ltd., Chengdu 610213, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialai","family":"Zhong","sequence":"additional","affiliation":[{"name":"Biogas Institute of Ministry of Agriculture and Rural Affairs, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Landscape Architecture, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-9332","authenticated-orcid":false,"given":"Haifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-5754","authenticated-orcid":false,"given":"Guangneng","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tvjl.2019.04.003","article-title":"Platelet indices as biomarkers for characterization and determination of severity in canine chronic enteropathy","volume":"248","author":"Mehain","year":"2019","journal-title":"Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wang, S., Martins, R., Sullivan, M.C., Friedman, E.S., Misic, A.M., El-Fahmawi, A., De Martinis, E.C.P., O\u2019Brien, K., Chen, Y., and Bradley, C. (2019). Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids. Microbiome, 7.","DOI":"10.1186\/s40168-019-0740-4"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Menozzi, A., Dall\u2019Aglio, M., Quintavalla, F., Dallavalle, L., Meucci, V., and Bertini, S. (2016). Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: A randomised trial. BMC Vet. Res., 12.","DOI":"10.1186\/s12917-016-0851-0"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Crist\u00f3bal, J.I., Duque, F.J., Us\u00f3n-Casa\u00fas, J.M., Ruiz, P., Nieto, E.L., and P\u00e9rez-Merino, E.M. (2021). Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Animals, 11.","DOI":"10.3390\/ani11072061"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, X., Gao, X., Hu, H., Xiao, Y., Li, D., Yu, G., Yu, D., Zhang, T., and Wang, Y. (2018). Clinical Efficacy and Microbiome Changes Following Fecal Microbiota Transplantation in Children with Recurrent Clostridium Difficile Infection. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.02622"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/jvim.15345","article-title":"Narrative review of therapies for chronic enteropathies in dogs and cats","volume":"33","author":"Makielski","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/19490976.2016.1151608","article-title":"Step-up fecal microbiota transplantation (FMT) strategy","volume":"7","author":"Cui","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"eaap9489","DOI":"10.1126\/scitranslmed.aap9489","article-title":"Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant","volume":"10","author":"Taur","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mooyottu, S., Muyyarikkandy, M.S., Yousefi, F., Li, G., Sahin, O., Burrough, E., Scaria, J., Sponseller, B., and Ramirez, A. (2025). Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets. Microbiome, 13.","DOI":"10.1186\/s40168-025-02042-9"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Niederwerder, M.C., Constance, L.A., Rowland, R.R.R., Abbas, W., Fernando, S.C., Potter, M.L., Sheahan, M.A., Burkey, T.E., Hesse, R.A., and Cino-Ozuna, A.G. (2018). Fecal Microbiota Transplantation Is Associated with Reduced Morbidity and Mortality in Porcine Circovirus Associated Disease. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01631"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-3-031-42108-2_5","article-title":"Fecal Microbiota Transplantation as Emerging Treatment in European Countries 2.0","volume":"1435","author":"Porcari","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.12938\/bmfh.2020-049","article-title":"Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease","volume":"40","author":"Niina","year":"2021","journal-title":"Biosci. Microbiota Food Health"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gal, A., Barko, P.C., Biggs, P.J., Gedye, K.R., Midwinter, A.C., Williams, D.A., Burchell, R.K., and Pazzi, P. (2021). One dog\u2019s waste is another dog\u2019s wealth: A pilot study of fecal microbiota transplantation in dogs with acute hemorrhagic diarrhea syndrome. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0250344"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chaitman, J., Ziese, A.L., Pilla, R., Minamoto, Y., Blake, A.B., Guard, B.C., Isaiah, A., Lidbury, J.A., Steiner, J.M., and Unterer, S. (2020). Fecal Microbial and Metabolic Profiles in Dogs with Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00192"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sugita, K., Yanuma, N., Ohno, H., Takahashi, K., Kawano, K., Morita, H., and Ohmori, K. (2019). Oral faecal microbiota transplantation for the treatment of Clostridium difficile-associated diarrhoea in a dog: A case report. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-018-1754-z"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/jvim.15072","article-title":"Fecal microbiota transplantation in puppies with canine parvovirus infection","volume":"32","author":"Pereira","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Cantas, L., Goll, R., Fenton, C.G., Paulssen, R.H., and S\u00f8rum, H. (2025). Impact of fecal microbiota transplantation in dogs. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1505226"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cvsm.2020.09.012","article-title":"Fecal Microbiota Transplantation in Dogs","volume":"51","author":"Chaitman","year":"2021","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_19","first-page":"197","article-title":"Improvement in Clinical Symptoms and Fecal Microbiome After Fecal Microbiota Transplantation in a Dog with Inflammatory Bowel Disease","volume":"10","author":"Niina","year":"2019","journal-title":"Vet. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41531-022-00328-5","article-title":"Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson\u2019s disease","volume":"8","author":"Nishiwaki","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.3748\/wjg.v22.i22.5211","article-title":"Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients","volume":"22","author":"Zhou","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tak\u00e1\u010dov\u00e1, M., Bomba, A., T\u00f3thov\u00e1, C., Mich\u00e1\u013eov\u00e1, A., and Tur\u0148a, H. (2022). Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?. Life, 12.","DOI":"10.3390\/life12050723"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100630","DOI":"10.1016\/j.tcam.2022.100630","article-title":"Observational Study of Small Animal Practitioners\u2019 Awareness, Clinical Practice and Experience with Fecal Microbiota Transplantation in Dogs","volume":"47","year":"2022","journal-title":"Top. Companion Anim. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Marclay, M., Dwyer, E., Suchodolski, J.S., Lidbury, J.A., Steiner, J.M., and Gaschen, F.P. (2022). Recovery of Fecal Microbiome and Bile Acids in Healthy Dogs after Tylosin Administration with and without Fecal Microbiota Transplantation. Vet. Sci., 9.","DOI":"10.3390\/vetsci9070324"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/jvim.17061","article-title":"Safety profile and effects on the peripheral immune response of fecal microbiota transplantation in clinically healthy dogs","volume":"38","author":"Lee","year":"2024","journal-title":"J. Vet. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Cerquetella, M., Marchegiani, A., Rossi, G., Trabalza-Marinucci, M., Passamonti, F., Isidori, M., and Rueca, F. (2022). Case Report: Oral Fecal Microbiota Transplantation in a Dog Suffering from Relapsing Chronic Diarrhea-Clinical Outcome and Follow-Up. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.893342"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Hirsch, B.E., Saraiya, N., Poeth, K., Schwartz, R.M., Epstein, M.E., and Honig, G. (2015). Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0930-z"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/vetsci11010042","article-title":"Microbiome Responses to Oral Fecal Microbiota Transplantation in a Cohort of Domestic Dogs","volume":"11","author":"Rojas","year":"2024","journal-title":"Vet. Sci."},{"key":"ref_29","unstructured":"(2001). Laboratory Animals-General Quality Standard for Formula Feeds (Standard No. GB\/T 14924.1-2001)."},{"key":"ref_30","unstructured":"Sichuan Anaerobic Biotechnology Limited Liability Company (2024). A Lyophilized Protective Agent for Intestinal Flora and Its Application. (CN118638635A), Patent."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2460\/ajvr.75.4.349","article-title":"Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs","volume":"75","author":"Gladwin","year":"2014","journal-title":"Am. J. Vet. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/nmo.12738","article-title":"Bristol Stool Form Scale reliability and agreement decreases when determining Rome III stool form designations","volume":"28","author":"Chumpitazi","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.5851\/kosfa.2018.e62","article-title":"Effects of Queso Blanco Cheese Containing Bifidobacterium longum KACC 91563 on the Intestinal Microbiota and Short Chain Fatty Acid in Healthy Companion Dogs","volume":"38","author":"Park","year":"2018","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cvsm.2020.09.004","article-title":"Impact of Changes in Gastrointestinal Microbiota in Canine and Feline Digestive Diseases","volume":"51","author":"Ziese","year":"2021","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/vetr.4915","article-title":"Harnessing the microbiome: Probiotics, antibiotics and their role in canine and feline gastrointestinal disease","volume":"195","author":"Schmid","year":"2024","journal-title":"Vet. Rec."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/19490976.2019.1704142","article-title":"The canine gastrointestinal microbiota: Early studies and research frontiers","volume":"11","author":"Huang","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kilian, E., Suchodolski, J.S., Hartmann, K., Mueller, R.S., Wess, G., and Unterer, S. (2018). Long-term effects of canine parvovirus infection in dogs. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192198"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.vetmic.2016.11.015","article-title":"A canine-specific probiotic product in treating acute or intermittent diarrhea in dogs: A double-blind placebo-controlled efficacy study","volume":"197","author":"Junnila","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.5713\/ab.23.0475","article-title":"Gut microbiota derived from fecal microbiota transplantation enhances body weight of Mimas squabs","volume":"37","author":"Ren","year":"2024","journal-title":"Anim. Biosci."},{"key":"ref_40","first-page":"784","article-title":"Clinical effectiveness of fecal microbiota transplantation combined with nutritional support and psychological intervention in patients with \u201cTetralogy of Tongji\u201d","volume":"25","author":"Lin","year":"2022","journal-title":"Zhonghua Wei Chang. Wai Ke Za Zhi"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Xue, L., Deng, Z., Luo, W., He, X., and Chen, Y. (2022). Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.759306"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e01965-16","DOI":"10.1128\/mBio.01965-16","article-title":"Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation","volume":"7","author":"Staley","year":"2016","journal-title":"mBio"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Berlanda, M., Innocente, G., Simionati, B., Di Camillo, B., Facchin, S., Giron, M.C., Savarino, E., Sebastiani, F., Fiorio, F., and Patuzzi, I. (2021). Faecal Microbiome Transplantation as a Solution to Chronic Enteropathies in Dogs: A Case Study of Beneficial Microbial Evolution. Animals, 11.","DOI":"10.3390\/ani11051433"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Weingarden, A., Gonz\u00e1lez, A., V\u00e1zquez-Baeza, Y., Weiss, S., Humphry, G., Berg-Lyons, D., Knights, D., Unno, T., Bobr, A., and Kang, J. (2015). Dynamic changes in short- and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection. Microbiome, 3.","DOI":"10.1186\/s40168-015-0070-0"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1794263","DOI":"10.1080\/19490976.2020.1794263","article-title":"Effects of fecal microbiota transplantation in subjects with irritable bowel syndrome are mirrored by changes in gut microbiome","volume":"12","author":"Goll","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11885","DOI":"10.1080\/21655979.2021.1999374","article-title":"Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules","volume":"12","author":"Guo","year":"2021","journal-title":"Bioengineered"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"609","DOI":"10.7326\/M16-0271","article-title":"Effect of Fecal Microbiota Transplantation on Recurrence in Multiply Recurrent Clostridium difficile Infection: A Randomized Trial","volume":"165","author":"Kelly","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Tuniyazi, M., Hu, X., Fu, Y., and Zhang, N. (2022). Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms. Vet. Sci., 9.","DOI":"10.3390\/vetsci9080396"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/gutjnl-2023-331550","article-title":"The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: Second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines","volume":"73","author":"Mullish","year":"2024","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"God\u00ednez-M\u00e9ndez, L.A., Gurrola-D\u00edaz, C.M., Zepeda-Nu\u00f1o, J.S., Vega-Maga\u00f1a, N., Lopez-Roa, R.I., \u00cd\u00f1iguez-Guti\u00e9rrez, L., Garc\u00eda-L\u00f3pez, P.M., Fafutis-Morris, M., and Delgado-Rizo, V. (2021). In Vivo Healthy Benefits of Galacto-Oligosaccharides from Lupinus albus (LA-GOS) in Butyrate Production through Intestinal Microbiota. Biomolecules, 11.","DOI":"10.3390\/biom11111658"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, W., Zheng, S., Li, L., Yang, Y., Liu, Y., Wang, A., Sharshov, K., and Li, Y. (2019). Comparative metagenomics of the gut microbiota in wild greylag geese (Anser anser) and ruddy shelducks (Tadorna ferruginea). Microbiologyopen, 8.","DOI":"10.1002\/mbo3.725"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sarmiento, J., Pulgar, R., Mandakovic, D., Porras, O., Flores, C.A., Luco, D., Trujillo, C.A., D\u00edaz-Esquivel, B., Alvarez, C., and Acevedo, A. (2022). Nocturnal Light Pollution Induces Weight Gain in Mice and Reshapes the Structure, Functions, and Interactions of Their Colonic Microbiota. Int. J. Mol. Sci., 2.","DOI":"10.3390\/ijms23031673"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105420","DOI":"10.1016\/j.phrs.2021.105420","article-title":"The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis","volume":"165","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1038\/s41396-021-00925-x","article-title":"Host genetics exerts lifelong effects upon hindgut microbiota and its association with bovine growth and immunity","volume":"15","author":"Fan","year":"2021","journal-title":"ISME J."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yang, X., Tai, Y., Ma, Y., Xu, Z., Hao, J., Han, D., Li, J., and Deng, X. (2022). Cecum microbiome and metabolism characteristics of Silky Fowl and White Leghorn chicken in late laying stages. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.984654"},{"key":"ref_57","first-page":"87","article-title":"Clinical response and changes in the fecal microbiota and metabolite levels after fecal microbiota transplantation in patients with inflammatory bowel disease and recurrent Clostridioides difficile infection","volume":"7","author":"Osaki","year":"2021","journal-title":"Fujita Med. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2011.02.018","article-title":"The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon","volume":"13","author":"Donohoe","year":"2011","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: The role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/ismej.2014.179","article-title":"Diet is a major factor governing the fecal butyrate-producing community structure across Mammalia, Aves and Reptilia","volume":"9","author":"Vital","year":"2015","journal-title":"ISME J."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/9\/909\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:48:24Z","timestamp":1760035704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/9\/909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["vetsci12090909"],"URL":"https:\/\/doi.org\/10.3390\/vetsci12090909","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}