{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:57:39Z","timestamp":1788623859051,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Animal-based measures, such as detecting inflammation in areas like the tail, ears, teats, coronary band, heels and claws (Swine Inflammation and Necrosis Syndrome, SINS), are used to monitor animal health and welfare. When parameters deviate from the established range, these measures enable prompt action to adjust husbandry practices, feeding regimens and management strategies. In addition to environmental factors, genetics have been shown to play a key role in inflammation and necrosis processes, and selection can reduce the severity of the disease. This study examined whether different breeds of AI boar exhibit different signs of SINS and how these signs are associated with SINS in their offspring when they are suckling piglets and weaners. Initially, 286 AI boars of 7 breeds from a German artificial insemination center were evaluated for SINS. The following parameters were assessed: tail base, tail tip, ears, skin, scrotum, coronary bands, heels and claws. Subsequently, 23 Pietrain and Duroc boars were used in combination with a Topigs DL sow line. The progeny of the AI boars was evaluated as suckling and weaned piglets, with the assessment framework encompassing SINS traits. The results revealed significant differences between the breeds and lines, as well as a strong correlation between the SINS phenotypes of the AI boars and the SINS scores of their offspring. The offspring of the 25% most extreme boars exhibited a 17% variation in SINS scores. This association was particularly evident when comparing the boars\u2019 tail base. However, the development of the boars\u2019 heels and claws was found to be significantly influenced by mechanical environmental factors and not associated with the piglets\u2019 scores. These findings imply that heritable, endogenous processes, as proposed for SINS, also visibly impact the phenotype of the AI boar. This study\u2019s fundamental premise suggests that pre-selecting AI boars could mitigate the occurrence of SINS and enhance piglet health and welfare.<\/jats:p>","DOI":"10.3390\/vetsci12100967","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:50:16Z","timestamp":1760107816000},"page":"967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Breed- and Line-Dependent Severity of Inflammation and Necrosis Syndrome in AI Boars, and the Related Risk of Inflammation and Necrosis in Their Progeny"],"prefix":"10.3390","volume":"12","author":[{"given":"Sabrina","family":"Becker","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kochendoerfer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kuehling","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Gerhards","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6305-6543","authenticated-orcid":false,"given":"Mirjam","family":"Lechner","sequence":"additional","affiliation":[{"name":"UEG Hohenlohe-Franken, Kraussenklinge 1, 97996 Niederstetten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zinner","sequence":"additional","affiliation":[{"name":"Besamungsverein Neustadt a.d. Aisch e.V., Franz-Ehrsam-Weg 1, 91413 Neustadt an der Aisch, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lautner","sequence":"additional","affiliation":[{"name":"Besamungsverein Neustadt a.d. Aisch e.V., Franz-Ehrsam-Weg 1, 91413 Neustadt an der Aisch, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-0345","authenticated-orcid":false,"given":"Gerald","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mellor, D.J. (2016). Updating Animal Welfare Thinking: Moving beyond the \u201cFive Freedoms\u201d towards \u201cA Life Worth Living\u201d. Animals, 6.","DOI":"10.3390\/ani6030021"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Animal Health and Welfare (AHAW), Nielsen, S.S., Alvarez, J., Bicout, D.J., Calistri, P., Canali, E., Drewe, J.A., Garin-Bastuji, B., Rojas, J.L.G., and Schmidt, G. (2022). Welfare of pigs on farm. EFSA J., 20, e07421.","DOI":"10.2903\/j.efsa.2022.7421"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7120\/09627286.26.2.203","article-title":"Welfare assessment in traditional mountain dairy farms: Above and beyond resource-based measures","volume":"26","author":"Zuliani","year":"2017","journal-title":"Anim. Welf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0962728600025641","article-title":"Animal-Based Measures for the Assessment of Welfare State of Dairy Cattle, Pigs and Laying Hens: Consensus of Expert Opinion","volume":"12","author":"Whay","year":"2003","journal-title":"Anim. Welf."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Animal Health and Welfare (AHAW) (2012). Statement on the use of animal-based measures to assess the welfare of animals. EFSA J., 10, 2767.","DOI":"10.2903\/j.efsa.2012.2767"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Koenders-van Gog, K., Wijnands, T., Lechner, M., Reiner, G., and Fink-Gremmels, J. (2025). Screening of Piglets for Signs of Inflammation and Necrosis as Early Life Indicators of Animal Health and Welfare Hazards. Animals, 15.","DOI":"10.3390\/ani15030378"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.animal.2020.100078","article-title":"An in-depth diagnostic exploration of an inflammation and necrosis syndrome in a population of newborn piglets","volume":"15","author":"Kuehling","year":"2021","journal-title":"Animal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40813-020-00170-2","article-title":"Swine Inflammation and Necrosis Syndrome is influenced by husbandry and quality of sow in suckling piglets, weaners and fattening pigs","volume":"6","author":"Reiner","year":"2020","journal-title":"Porc. Health Manag."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Reiner, G., Kuehling, J., Loewenstein, F., Lechner, M., and Becker, S. (2021). Swine Inflammation and Necrosis Syndrome (SINS). Animals, 11.","DOI":"10.3390\/ani11061670"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/PAVSNNR201914040","article-title":"Inflammation and necrosis syndrome (SINS) in swine","volume":"14","author":"Reiner","year":"2019","journal-title":"CAB Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"skad067","DOI":"10.1093\/jas\/skad067","article-title":"The genetic basis of swine inflammation and necrosis syndrome and its genetic association with post-weaning skin damage and production traits","volume":"101","author":"Leite","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_12","first-page":"301","article-title":"\u00c9valuation de la pr\u00e9valence du syndrome inflammatoire et n\u00e9crotique porcin dans les troupeaux fran\u00e7ais","volume":"56","author":"Fortune","year":"2024","journal-title":"Journ\u00e9es Rech. Porc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF01225491","article-title":"Histological and enzyme histochemical parameters for the age estimation of human skin wounds","volume":"107","author":"Betz","year":"1994","journal-title":"Int. J.-Nal. Leg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Loewenstein, F., Becker, S., Kuehling, J., Schrade, H., Lechner, M., Ringseis, R., Eder, K., Moritz, A., and Reiner, G. (2022). Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-021-03107-1"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ringseis, R., Gessner, D.K., Loewenstein, F., Kuehling, J., Becker, S., Willems, H., Lechner, M., Eder, K., and Reiner, G. (2021). Swine Inflammation and Necrosis Syndrome Is Associated with Plasma Metabolites and Liver Transcriptome in Affected Piglets. Animals, 11.","DOI":"10.3390\/ani11030772"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., Kuehling, J., Lechner, M., Willems, H., Ringseis, R., and Reiner, G. (2025). Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome. BMC Vet. Res., 21.","DOI":"10.1186\/s12917-024-04469-y"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1017\/S1751731118003403","article-title":"Prevalence of an inflammation and necrosis syndrome in suckling piglets","volume":"13","author":"Reiner","year":"2019","journal-title":"Animal"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40813-021-00194-2","article-title":"The effects of boar on susceptibility to swine inflammation and necrosis syndrome in piglets","volume":"7","author":"Kuehling","year":"2021","journal-title":"Porc. Health Managem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00335-023-10011-6","article-title":"GWAS reveals genomic associations with swine inflammation and necrosis syndrome","volume":"34","author":"Gerhards","year":"2023","journal-title":"Mamm. Genome"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., K\u00fchling, J., Mickan, J., Lechner, M., Willems, H., and Reiner, G. (2025). Fine Mapping Identifies Candidate Genes Associated with Swine Inflammation and Necrosis Syndrome. Vet. Sci., 12.","DOI":"10.3390\/vetsci12050508"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Becker, S., Hindenlang, K., Kuehling, J., Lechner, M., and Reiner, G. (2025). Inflammation and Necrosis Syndrome in Young Piglets\u2014A Longitudinal Study. Vet. Sci., 12.","DOI":"10.3390\/vetsci12080752"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0167-5877(99)00006-9","article-title":"The prevalence and risk factors associated with forelimb skin abrasions and sole bruising in preweaning piglets","volume":"39","author":"Mouttotou","year":"1999","journal-title":"Prev. Vet. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1746-6148-5-31","article-title":"A cross sectional study of prevalence, risk factors, population attributable fractions and pathology for foot and limb lesions in preweaning piglets on commercial farms in England","volume":"5","author":"Kilbride","year":"2009","journal-title":"BMC Vet. Res."},{"key":"ref_24","unstructured":"L\u00f6sel, D., Dodenhoff, J., Eisenreich, R., and G\u00f6tz, K.U. (2024, January 18\u201319). Untersuchungen zur Erblichkeit des Schweine-Entz\u00fcndungs- und Nekrose-syndroms\u2014Erste Ergebnisse aus dem Projekt HeriSINS. Proceedings of the Vortragstagung der DGfZ und GfT, G\u00f6ttingen, Germany. Available online: https:\/\/www.lfl.bayern.de\/mam\/cms07\/itz\/dateien\/herisins_ergebnisse_der_dgfz-vortragsveranstaltung_2024.pdf."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1189\/jlb.1110607","article-title":"The mononuclear phagocyte system of the pig as a model for understanding humaninnate immunity and disease","volume":"89","author":"Fairbairn","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-Associated Molecular Patterns in Inflammatory Diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: Signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.4049\/jimmunol.0802059","article-title":"Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation","volume":"182","author":"Samuvel","year":"2009","journal-title":"J. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Manosalva, C., Quiroga, J., Hidalgo, A.I., Alarc\u00f3n, P., Anseoleaga, N., Hidalgo, M.A., and Burgos, R.A. (2022). Role of Lactate in Inflammatory Processes: Friend or Foe. Front. Immunol., 12, Erratum in: Front. Immunol. 2025, 16, 1553925. https:\/\/doi.org\/10.3389\/fimmu.2025.1553925. PMID: 35095895; PMCID: PMC8795514.","DOI":"10.3389\/fimmu.2025.1553925"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41590-023-01555-5","article-title":"Stress-induced inflammation","volume":"24","author":"Visan","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ajpath.2012.09.010","article-title":"Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation","volume":"182","author":"Corbitt","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_32","first-page":"225","article-title":"Endotoxemia in protein-energy malnutrition","volume":"7","author":"Klein","year":"1988","journal-title":"J. Pediatr. Gastroent. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ortega, A.D.S.V., and Szab\u00f3, C. (2021). Adverse Effects of Heat Stress on the Intestinal Integrity and Function of Pigs and the Mitigation Capacity of Dietary Antioxidants: A Review. Animals, 11.","DOI":"10.3390\/ani11041135"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9851914","DOI":"10.1155\/2021\/9851914","article-title":"The Interplay of Oxidative Stress and Inflammation: Mechanistic Insights and Therapeutic Potential of Antioxidants","volume":"2021","author":"Ayman","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Pearce, C.S., Mani, V., Boddicker, R.L., Johnson, J.S., Weber, T.E., Ross, J.W., Rhoads, R.P., Baumgard, L.H., and Gabler, N.K. (2013). Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070215"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2527\/jas.52339","article-title":"Heat stress reduces barrier function and alters intestinal metabolism in growing pigs","volume":"90","author":"Pearce","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e00591-20","DOI":"10.1128\/mSystems.00591-20","article-title":"Consumption of Dietary Fiber from Different Sources during Pregnancy Alters Sow Gut Microbiota and Improves Performance and Reduces Inflammation in Sows and Piglets","volume":"6","author":"Liu","year":"2021","journal-title":"mSystems"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1093\/jas\/skz278","article-title":"Effects of dietary fiber sources during late gestation and lactation on sow performance, milk quality, and intestinal health in piglets1","volume":"97","author":"Shang","year":"2019","journal-title":"J. Anim. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.aninu.2020.10.001","article-title":"Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance","volume":"6","author":"Tian","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_42","first-page":"e1247","article-title":"Heat stress increases insulin sensitivity in pigs","volume":"3","author":"Stoakes","year":"2015","journal-title":"Physiol. Repetit."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sahasrabudhe, N., Beukema, M., Tian, L., Troost, B., Scholte, J., Bruininx, E., Bruggeman, G., van den Berg, M., Scheurink, A., and Schols, H. (2018). Dietary fiber pectin directly blocks Toll-like receptor 2-1 and prevents doxorubicin-induced ileitis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00383"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Luu, M., Monning, H., and Visekruna, A. (2020). Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01225"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1017\/S1751731111000772","article-title":"Oxidative stress status of highly prolific sows during gestation and lactation","volume":"5","author":"Kim","year":"2011","journal-title":"Animal"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e01047-18","DOI":"10.1128\/AEM.01047-18","article-title":"Maternal soluble fiber diet during pregnancy changes the intestinal microbiota, improves growth performance, and reduces intestinal permeability in piglets","volume":"84","author":"Cheng","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Aponte-Mellado, A., Premkumar, B.J., Shaman, A., and Gupta, S. (2012). The effects of oxidative stress on female reproduction: A review. Reprod. Biol. Endocrinol., 10.","DOI":"10.1186\/1477-7827-10-49"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1017\/S1751731118001684","article-title":"Follicular development of sows at weaning in relation to estimated breeding value for within-litter variation in piglet birth weight","volume":"13","author":"Costermans","year":"2019","journal-title":"Animal"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1530\/REP-09-0247","article-title":"Inflammatory pathways in female reproductive health and disease","volume":"138","author":"Jabbour","year":"2009","journal-title":"Reproduction"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sawicki, C.M., Livingston, K.A., Obin, M., Roberts, S.B., Chung, M., and McKeown, N.M. (2017). Dietary fiber and the human gut microbiota: Application of evidence mapping methodology. Nutrients, 9.","DOI":"10.3390\/nu9020125"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.3945\/jn.115.217406","article-title":"Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets","volume":"145","author":"Huang","year":"2015","journal-title":"J. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41579-018-0036-x","article-title":"Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier","volume":"16","author":"Martens","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_53","first-page":"167","article-title":"Invited review: Bacterial lipopolysaccharides and innate immunity","volume":"7","author":"Alexander","year":"2001","journal-title":"J. Endotoxin Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2174\/092986708784872393","article-title":"Human endotoxemia as a model of systemic inflammation","volume":"15","author":"Andreasen","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1017\/S0007114512001213","article-title":"Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia","volume":"108","author":"Moreira","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ijo.2016.26","article-title":"Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents","volume":"40","author":"Rainone","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.physbeh.2018.09.018","article-title":"Sick and grumpy: Changes in social behaviour after a controlled immune stimulation in group-housed gilts","volume":"198","author":"Munsterhjelm","year":"2019","journal-title":"Physiol. Behav."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Nordgreen, J., Edwards, S.A., Boyle, L.A., Bolhuis, J.E., Veit, C., Sayyari, A., Marin, D.E., Dimitrov, I., Janczak, A.M., and Valros, A. (2020). A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00646"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12550-014-0201-7","article-title":"Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig","volume":"30","author":"Valenta","year":"2014","journal-title":"Mycotox. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0300-483X(01)00523-6","article-title":"Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents","volume":"169","author":"Ganey","year":"2001","journal-title":"Toxicology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/vr.104385","article-title":"Role of mycotoxins in herds with and without problems with tail necrosis in neonatal pigs","volume":"181","author":"Devreese","year":"2017","journal-title":"Vet. Rec."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0007-1935(86)90032-1","article-title":"Pathophysiological effects of endotoxin infusion in young piglets","volume":"142","author":"Schrauwen","year":"1986","journal-title":"Br. Vet. J."},{"key":"ref_63","first-page":"396","article-title":"Long-term effect of fusariotoxins on the reproduction performance of sows testing the effectiveness of detoxifying feed additives 700","volume":"10","author":"Jadamus","year":"2002","journal-title":"Feed Magzine"},{"key":"ref_64","unstructured":"Busch, M.E., Jensen, I.M., and Korsgaard, J. (2010, January 18\u201321). Development and consequences of ear necrosis in a weaner herd and two growingfinishing herds. Proceedings of the 21st International Pig Veterinary Society Congress, Vancouver, BC, Canada."},{"key":"ref_65","first-page":"269","article-title":"Mise en evidence du transfer des endotoxines de la truie vers sa port\u00e9e dans le context du syndrome de dysgalactie post-partum","volume":"45","author":"Guillou","year":"2013","journal-title":"J. Rech. Porc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1113\/jphysiol.1972.sp009896","article-title":"The post-natal changes in minimal metabolic rate in the pig","volume":"224","author":"Studzinski","year":"1972","journal-title":"J. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1017\/S1357729800058781","article-title":"Describing and predicting potential growth in the pig","volume":"78","author":"Wellock","year":"2004","journal-title":"Anim. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.5713\/ajas.2013.r.02","article-title":"Feed energy evaluation for growing pigs","volume":"26","author":"Kil","year":"2013","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.2527\/jas.2013-7002","article-title":"Estimation of the net energy requirements for maintenance in growing and finishing pigs","volume":"92","author":"Zhang","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12711-021-00609-2","article-title":"Selection for social genetic effects in purebreds increases growth in crossbreds","volume":"53","author":"Ask","year":"2021","journal-title":"Genet. Sel. Evol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Hayward, A., and Gillooly, J.F. (2011). The cost of sex: Quantifying energetic investment in gamete production by males and females. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016557"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"skac408","DOI":"10.1093\/jas\/skac408","article-title":"Lifetime and removal reasons for Pietrain boars in European AI centers: A retrospective analysis","volume":"101","author":"Henneberg","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1071\/EA04017","article-title":"Genetic improvement of lean meat growth and feed efficiency in pigs","volume":"44","author":"Hermesch","year":"2004","journal-title":"Aust. J. Exp. Agric."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5194\/aab-64-177-2021","article-title":"Unintended consequences of selection for increased production on the health and welfare of livestock","volume":"64","author":"Visser","year":"2021","journal-title":"Arch. Anim. Breed."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Rauw, W.M., Johnson, A.K., Gomez-Raya, L., and Dekkers, J.C.M. (2017). Hypothesis and Review of the Relationship between Selection for Improved Production Efficiency, Coping Behavior, and Domestication. Front. Genet., 8.","DOI":"10.3389\/fgene.2017.00134"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Mathur, P.K., Vogelzang, R., Mulder, H.A., and Knol, E.F. (2018). Genetic Selection to Enhance Animal Welfare Using Meat Inspection Data from Slaughter Plants. Animals, 8.","DOI":"10.3390\/ani8020016"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1017\/S175173111600286X","article-title":"Review: Divergent selection for residual feed intake in the growing pig","volume":"11","author":"Gilbert","year":"2017","journal-title":"Animal"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12711-023-00860-9","article-title":"Genetic analysis of the blood transcriptome of young healthy pigs to improve disease resilience","volume":"55","author":"Lim","year":"2023","journal-title":"Genet. Sel. Evol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Papatsiros, V.G., Maragkakis, G., and Papakonstantinou, G.I. (2024). Stress Biomarkers in Pigs: Current Insights and Clinical Application. Vet. Sci., 11.","DOI":"10.3390\/vetsci11120640"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1152\/japplphysiol.00497.2022","article-title":"Lactate as a myokine and exerkine: Drivers and signals of physiology and metabolism","volume":"134","author":"Brooks","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0309-1740(85)80003-6","article-title":"Skeletal muscle characteristics in different breeds of pigs in relation to sensory properties of meat","volume":"13","year":"1985","journal-title":"Meat Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2527\/2006.84193x","article-title":"Low birth weight is associated with enlarged muscle fiber area and impaired meat tenderness of the longissimus muscle in pigs","volume":"84","author":"Gondret","year":"2006","journal-title":"J. Anim. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3182746","DOI":"10.1155\/2016\/3182746","article-title":"How Muscle Structure and Composition InfluenceMeat and Flesh Quality","volume":"2016","author":"Listrat","year":"2016","journal-title":"Sci. World J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0309-1740(02)00186-9","article-title":"Factors of Significance For Pork Quality\u2014A Review","volume":"64","author":"Rosenvold","year":"2003","journal-title":"Meat Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Feng, J., Zhu, L., He, C., Xiang, R., Liu, J., Cai, J., and Wang, D. (2025). Lactate induces oxidative stress by HIF1\u03b1 stabilization and circadian clock disturbance in mammary gland of dairy cows. J. Anim. Sci. Biotechnol., 16.","DOI":"10.1186\/s40104-025-01181-1"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2024.12.009","article-title":"Lactate homeostasis is maintained through regulation of glycolysis and lipolysis","volume":"37","author":"Lee","year":"2025","journal-title":"Cell Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism: A new paradigm for the third millennium","volume":"558","author":"Gladden","year":"2004","journal-title":"J. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archsurg.135.11.1293","article-title":"Effect of hyperoxia on vascular endothelial growth factor levels in a wound model","volume":"135","author":"Sheikh","year":"2000","journal-title":"Arch. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1524-475X.2003.11608.x","article-title":"Role of ADP-ribosylation in wound repair. The contributions of Thomas K. Hunt, MD","volume":"11","author":"Ghani","year":"2003","journal-title":"Wound Repair. Regen."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1524-475X.2000.00353.x","article-title":"Lactate elicits vascular endothelial growth factor from macrophages: A possible alternative to hypoxia","volume":"8","author":"Constant","year":"2000","journal-title":"Wound Repair. Regen."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1046\/j.1524-475X.2003.11621.x","article-title":"Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing","volume":"11","author":"Trabold","year":"2003","journal-title":"Wound Repair. Regen."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S1097-2765(00)80221-X","article-title":"Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability","volume":"4","author":"Eliceiri","year":"1999","journal-title":"Mol. Cell."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cbi.2007.08.006","article-title":"Regulation of endothelial permeability by Src kinase signaling: Vascular leakage versus transcellular transport of drugs and macromolecules","volume":"171","author":"Hu","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bbrc.2010.07.124","article-title":"New molecular mechanisms of the unexpectedly complex role of VEGF in ulcerative colitis","volume":"399","author":"Tolstanova","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"435","DOI":"10.5713\/ajas.14.0322","article-title":"Correlations among Stress Parameters, Meat and Carcass Quality Parameters in Pigs","volume":"28","author":"Dokmanovic","year":"2015","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_96","first-page":"93","article-title":"Belastung durch die Samenentnahme am Phantom: Effekte auf Herz-Kreislauf-System, S\u00e4ure-Basen-Haushalt und Plasmaenzyme bei Eber der Rassen Landrasse und Pietrain","volume":"3","author":"Perez","year":"1988","journal-title":"Tierarztl. Prax."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0739-7240(01)00123-0","article-title":"Biology of leptin in the pig","volume":"21","author":"Barb","year":"2001","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Choi, I., Steibel, J.P., Bates, R.O., Raney, N.E., Rumph, J.M., and Ernst, C.W. (2010). Application of alternative models to identify QTL for growth traits in an F2 Duroc x Pietrain pig resource population. BMC Genet., 11.","DOI":"10.1186\/1471-2156-11-97"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cyto.2016.10.011","article-title":"Leptin in inflammation and autoimmunity","volume":"98","year":"2017","journal-title":"Cytokine"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/10\/967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:29:14Z","timestamp":1760110154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/12\/10\/967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":99,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["vetsci12100967"],"URL":"https:\/\/doi.org\/10.3390\/vetsci12100967","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}