{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:14:09Z","timestamp":1787030049962,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["xx"],"award-info":[{"award-number":["xx"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306690\/2021-7"],"award-info":[{"award-number":["306690\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["xx"],"award-info":[{"award-number":["xx"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Canine melanoma is a relatively common and clinically significant neoplasm in veterinary oncology, with important prognostic implications. Epithelial\u2013mesenchymal transition (EMT), associated with changes in cell adhesion and increased metastatic potential, remains poorly characterized in this tumor type. We evaluated E-cadherin and N-cadherin expression in 32 primary canine melanomas and their regional lymph nodes, assessing associations with tumor progression and survival. Regional lymph node metastases were observed in 53% of cases. High N-cadherin expression in primary tumors correlated with metastasis and reduced survival, while E-cadherin expression showed no difference between metastatic and non-metastatic tumors. Notably, metastatic primary tumors exhibited a positive correlation between E- and N-cadherin expression. These results indicate that N-cadherin is a potential prognostic marker; and highlight the need for further studies on EMT as a therapeutic target to control metastasis.<\/jats:p>","DOI":"10.3390\/vetsci12111023","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:14:02Z","timestamp":1761182042000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["N-Cadherin-Mediated Epithelial\u2013Mesenchymal Transition as a Prognostic Indicator in Canine Melanoma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7382-2689","authenticated-orcid":false,"given":"Thacyana Beatriz Guimar\u00e3es","family":"Lopes","sequence":"first","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana Yively Osorio","family":"Taborda","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice Soares","family":"Fenelon","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara","family":"de Oliveira Duarte","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0662-9577","authenticated-orcid":false,"given":"Karen Yumi Ribeiro","family":"Nakagaki","sequence":"additional","affiliation":[{"name":"CelulaVet\u2014Centro de Diagn\u00f3stico Veterin\u00e1rio, Belo Horizonte 31365-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-4300","authenticated-orcid":false,"given":"Camila Costa","family":"Abreu","sequence":"additional","affiliation":[{"name":"PatoVetVale\u2014Patologia Veterin\u00e1ria do Vale, Taubat\u00e9 12050-470, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Cunha","family":"Flecher","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria, Universidade Vila Velha, Vila Velha 29102-623, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-7401","authenticated-orcid":false,"given":"Helen Lima","family":"Del Puerto","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-0303","authenticated-orcid":false,"given":"Enio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e230111335332","DOI":"10.33448\/rsd-v11i13.35332","article-title":"Oral cavity melanoma in dogs: Epidemiological, clinical, and pathological characteristics","volume":"11","author":"Colombo","year":"2022","journal-title":"Res. 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