{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:59:38Z","timestamp":1792807178177,"version":"4.5.0"},"reference-count":22,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32473095"],"award-info":[{"award-number":["32473095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32373061"],"award-info":[{"award-number":["32373061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010035","name":"Outstanding Youth Foundation of Jiangsu Province of China","doi-asserted-by":"crossref","award":["BK20231524"],"award-info":[{"award-number":["BK20231524"]}],"id":[{"id":"10.13039\/501100010035","id-type":"DOI","asserted-by":"crossref"}]},{"name":"East Lake Future Star Research Program","award":["2025DHWL012"],"award-info":[{"award-number":["2025DHWL012"]}]},{"name":"Research Project of Hubei Provincial Department of Education","award":["B2024299"],"award-info":[{"award-number":["B2024299"]}],"id":[{"id":"https:\/\/ror.org\/05yaa9j15","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013314","name":"111 Project","doi-asserted-by":"crossref","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>V. furnissii is a marine bacterium capable of infecting both invertebrates and humans. However, the mechanisms underlying its drug resistance and virulence remain largely elusive. In this study, we isolated a multidrug-resistant V. furnissii strain, MT14, from bivalve mollusks. Genomic analysis revealed that MT14 carries a novel pAQU-type plasmid, designated pMT14, which harbors six antibiotic resistance genes: qnrS2, qnrVC6, dfrA31, tetA; sul2, and blaGMA-1. Notably, blaGMA-1 and its variants confer resistance to penicillin-class antibiotics, including ampicillin, amoxicillin, and carbenicillin. Comparative genomic analysis further revealed that V. furnissii strains commonly encode T6SS1, T6SS2, and the hemolysin gene vfh, while only five sequenced strains carry zot toxin gene. To our knowledge, this is the first report of zot in V. furnissii. In addition, the absence of drug resistance genes in the majority of genomes (73.3%, 22\/30) suggests that such traits are not intrinsic to the species but have been acquired by specific strains, likely through plasmid transfer or other mobile genetic elements. The emergence of blaGMA-1 and zot in V. furnissii represents a potential public health concern, underscoring the need for enhanced surveillance of antimicrobial resistance in marine pathogens.<\/jats:p>","DOI":"10.3390\/vetsci12121180","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:20:57Z","timestamp":1765369257000},"page":"1180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic Features of Antimicrobial Resistance and Virulence in Multidrug-Resistant Vibrio\u00a0furnissii"],"prefix":"10.3390","volume":"12","author":[{"given":"Xuemei","family":"Wu","sequence":"first","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Management, Wuhan Donghu College, Wuhan 430040, China"},{"name":"National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-9600","authenticated-orcid":false,"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-9891","authenticated-orcid":false,"given":"Ruichao","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jip.2010.10.006","article-title":"Isolation and characterization of a virulent Vibrio sp. bacterium from clams (Meretrix meretrix) with mass mortality","volume":"106","author":"Yue","year":"2011","journal-title":"J. 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