{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T06:31:40Z","timestamp":1766212300350,"version":"3.48.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Faculty of Veterinary Medicine, Kasetsart University","award":["VET.KU2025-07"],"award-info":[{"award-number":["VET.KU2025-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Feline cryptococcosis is a common systemic mycosis that typically begins in the nasal cavity and can extend to the eyes, skin, and CNS. Objective monitoring during therapy remains limited. This study aimed to test whether serial serum cryptococcal antigen titers (CALAS) and a simple six-domain clinical score can track response, and to describe clinicopathologic trends during amphotericin B and fluconazole treatment. We retrospectively reviewed cases from 2014 to 2023 and analyzed a single-center cohort of 35 cats. Management used amphotericin B plus fluconazole for ~3\u20134 months, then fluconazole maintenance. Monthly assessments included CALAS (log2), the clinical score (0\u201318), and routine hematology\/biochemistry; mixed-effects models tested change over time. CALAS fell (mean log2 12.00 to 6.79), total leukocytes decreased (16.85 \u00d7 109\/L to 10.90 \u00d7 109\/L) with a similar neutrophil decline, alanine aminotransferase remained stable, and blood urea nitrogen\/creatinine increased in some cats. The clinical score improved from 3.83 to 0.68. Seven cats developed azotemia during amphotericin B; the drug was stopped, renal values normalized in three, and four remained azotemic at the last follow-up. These findings support the use of CALAS and a simple score as practical monitoring tools and underscore the need for routine renal surveillance.<\/jats:p>","DOI":"10.3390\/vetsci12121211","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:15:21Z","timestamp":1766049321000},"page":"1211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Features, Treatment Outcome, and the Cryptococcal Antigen Latex Agglutination System Titer in Feline Cryptococcosis Treated with Amphotericin B and Fluconazole"],"prefix":"10.3390","volume":"12","author":[{"given":"Suprawee","family":"Treekhunrungruang","sequence":"first","affiliation":[{"name":"Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-0052","authenticated-orcid":false,"given":"Chompoonek","family":"Yurayart","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-6111","authenticated-orcid":false,"given":"Chaiyakorn","family":"Thitiyanaporn","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-8297","authenticated-orcid":false,"given":"Tassanee","family":"Jaroensong","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/1098612X13489224","article-title":"Cryptococcosis in cats: ABCD guidelines on prevention and management","volume":"15","author":"Pennisi","year":"2013","journal-title":"J. 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