{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:42:31Z","timestamp":1768221751836,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","doi-asserted-by":"publisher","award":["RS-2025-24683314"],"award-info":[{"award-number":["RS-2025-24683314"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Ureterolithiasis is a common cause of ureteral obstruction in dogs, often leading to kidney injury. Medical expulsive therapy (MET) using \u03b1-adrenergic antagonists has been proposed as a nonsurgical treatment option in selected cases and is thought to facilitate ureteral stone passage by reducing ureteral smooth muscle tone. A 9-year-old castrated male Chihuahua weighing 1.78 kg was presented with anorexia. Physical examination revealed 7% dehydration and pale mucous membranes. Serum biochemistry demonstrated severe azotemia, with markedly elevated symmetric dimethylarginine (&gt;100 \u03bcg\/dL; reference interval [RI], 0\u201314 \u03bcg\/dL), blood urea nitrogen (157.9 mg\/dL; RI, 7\u201325 mg\/dL), and creatinine (2.2 mg\/dL; RI, 0.5\u20131.5 mg\/dL). On day 4 of hospitalization, ultrasonography revealed dilation of the renal pelvis (16.1 mm), ureteral distention (3.74 mm), and multiple ureteroliths (maximum diameter, 3.31 mm) at the ureterovesical junction. Antegrade pyelography confirmed a right ureteral obstruction. As the owner declined surgical intervention, MET including tamsulosin, was initiated with close clinical monitoring. After 3 days, improvement in azotemia and resolution of ureteral obstruction were observed. Although concurrent medical treatments were administered, this case provides clinical insight into the potential role of tamsulosin as part of medical management of obstructive ureterolithiasis in a dog with small distal ureteral stones.<\/jats:p>","DOI":"10.3390\/vetsci13010069","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:13:01Z","timestamp":1768209181000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Treatment of Obstructive Ureterolithiasis with Medical Expulsive Therapy Including Tamsulosin in a Dog"],"prefix":"10.3390","volume":"13","author":[{"given":"Chaeyeon","family":"Park","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-0849","authenticated-orcid":false,"given":"Yelim","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-6900","authenticated-orcid":false,"given":"Yeon","family":"Chae","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1372-4430","authenticated-orcid":false,"given":"Taesik","family":"Yun","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-4342","authenticated-orcid":false,"given":"Byeong-Teck","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-2329","authenticated-orcid":false,"given":"Hakhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/00480169.2005.36464","article-title":"Diagnosis and Surgical Management of Ureteral Calculi in Dogs: 16 Cases (1990\u20132003)","volume":"53","author":"Snyder","year":"2005","journal-title":"N. Z. Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1476-4431.2011.00628.x","article-title":"Ureteral Obstructions in Dogs and Cats: A Review of Traditional and New Interventional Diagnostic and Therapeutic Options","volume":"21","author":"Berent","year":"2011","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_3","unstructured":"Ettinger, S.J., Feldman, E.C., and C\u00f4t\u00e9, E. (2017). Diseases of the Lower Urinary Tract. Textbook of Veterinary Internal Medicine: Expert Consult, Elsevier. [8th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/jvim.14559","article-title":"ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats","volume":"30","author":"Lulich","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/j.1464-410X.2008.08022.x","article-title":"An in Vitro Study on Human Ureteric Smooth Muscle with the Alpha1-Adrenoceptor Subtype Blocker, Tamsulosin","volume":"102","author":"Rajpathy","year":"2008","journal-title":"BJU Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.ajem.2016.09.009","article-title":"Tamsulosin for Urolithiasis: A Review of the Recent Literature and Current Controversies","volume":"34","author":"Pourmand","year":"2016","journal-title":"Am. J. Emerg. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00240-005-0508-0","article-title":"The Use of Tamsulosin in the Medical Treatment of Ureteral Calculi: Where Do We Stand?","volume":"33","author":"Autorino","year":"2005","journal-title":"Urol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.juro.2007.09.107","article-title":"2007 Guideline for the Management of Ureteral Calculi","volume":"178","author":"Preminger","year":"2007","journal-title":"J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4111\/kju.2012.53.10.699","article-title":"Impact of Tamsulosin on Ureter Stone Expulsion in Korean Patients: A Meta-Analysis of Randomized Controlled Studies","volume":"53","author":"Lee","year":"2012","journal-title":"Korean J. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chae, H.K., Hong, H.J., Lee, S.Y., Park, J.H., Choi, W.J., Oh, S., Ji, S., and Hong, Y.J. (2022). Factors Affecting the Outcome of Medical Treatment in Cats with Obstructive Ureteral Stones Treated with Tamsulosin: 70 Cases (2018\u20132022). Vet. Sci., 9.","DOI":"10.3390\/vetsci9100568"},{"key":"ref_11","unstructured":"Thrall, D.E. (2018). Kidneys and Ureters. Textbook of Veterinary Diagnostic Radiology, Elsevier. [7th ed.]."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4111\/kju.2008.49.11.1013","article-title":"The Efficacy of Furosemide-Based Medical Expulsive Therapy with Tamsulosin and Deflazacort for Symptomatic Distal Ureter Stones","volume":"49","author":"Jang","year":"2012","journal-title":"Korean J. Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cvsm.2018.11.004","article-title":"Medical and Interventional Management of Upper Urinary Tract Uroliths","volume":"49","author":"Milligan","year":"2019","journal-title":"Vet. Clin. N. Am.-Small Anim. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.annemergmed.2007.05.015","article-title":"A Systematic Review of Medical Therapy to Facilitate Passage of Ureteral Calculi","volume":"50","author":"Singh","year":"2007","journal-title":"Ann. Emerg. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2214\/ajr.182.4.1821039","article-title":"Normal Ureter Size on Unenhanced Helical CT","volume":"182","author":"Zelenko","year":"2004","journal-title":"Am. J. Roentgenol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2009.04.030","article-title":"Effects of Silodosin and Tamsulosin on the Urethra and Cardiovascular System in Young and Old Dogs with Benign Prostatic Hyperplasia","volume":"613","author":"Kobayashi","year":"2009","journal-title":"Eur. J. 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