{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:26:40Z","timestamp":1790605600450,"version":"4.1.0"},"reference-count":159,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Cantrell syndrome (CS) is a rare congenital disorder involving defects in the thoraco-abdominal midline, the diaphragm, the pericardium, the sternum and the heart. Since the initial description of the syndrome, 165 well-documented cases in humans have been reported, demonstrating substantial heterogeneity ranging from complete pentalogy to partial or atypical variants. A systematic review classified body wall defects and associated anomalies into nine categories, which are fully described in the manuscript. The categories include midline defects (UThAb, SUThAb, UAb, SUAb, SUICD, and UH), lateral defects (ThLAb and StLAb), and special cases. Each case was reassessed for umbilical cord status, body wall morphology, cardiac anomalies and additional malformations. Midline defects predominated (153 out of 165 cases, 92.7%), with supraumbilical variants being the most frequent. Umbilical hernias formed a distinct subgroup of ten cases. Lateral defects were uncommon (9 cases, 5.5%) and typically presented as thoracogastroschisis or lateral thoracoabdominoschisis. These defects were often associated with normal umbilical cords. Cardiac anomalies were universal, with ventricular and atrial septal defects being the most common findings. Reclassification revealed that many cases originally labeled as \u2018classic pentalogy of Cantrell\u2019 were more accurately classified as partial or atypical forms. This unified framework improves epidemiological understanding and diagnostic precision. From a One Health perspective, it underscores CS as a shared developmental vulnerability across mammalian species.<\/jats:p>","DOI":"10.3390\/vetsci13020165","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:15:54Z","timestamp":1770624954000},"page":"165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cantrell Syndrome and the One Health Perspective: A Unified Review of Human and Comparative Cases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-5506","authenticated-orcid":false,"given":"Nieves","family":"Mart\u00edn-Alguacil","sequence":"first","affiliation":[{"name":"Research Group GIMCAD 971005-UCM, Departmental Section of Anatomy and Embryology, School of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-6080","authenticated-orcid":false,"given":"Luis","family":"Avedillo","sequence":"additional","affiliation":[{"name":"Research Group GIMCAD 971005-UCM, Departmental Section of Anatomy and Embryology, School of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"ref_1","first-page":"602","article-title":"A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium, and heart","volume":"107","author":"Cantrell","year":"1958","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00690470","article-title":"Exencephaly in Cantrell-Haller-Ravitsch Syndrome","volume":"65","author":"Hori","year":"1984","journal-title":"Acta Neuropathol."},{"key":"ref_3","first-page":"255","article-title":"Das Cantrellsche Syndrom [Cantrell\u2019s syndrome]","volume":"42","author":"Zachariou","year":"1987","journal-title":"Z. Kinderchir."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0022-3468(05)80006-5","article-title":"Pars sternalis diaphragmatic hernia with omphalocele: A report of two cases","volume":"25","author":"Milne","year":"1990","journal-title":"J. Pediatr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1469-0705.1991.01060431.x","article-title":"Prenatal sonographic diagnosis and perinatal management of ectopia cordis","volume":"1","author":"Achiron","year":"1991","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1055\/s-2007-1005224","article-title":"Pr\u00e4natale Diagnose einer Cantrellschen Pentalogie kombiniert mit Exenzephalie und Amnionbridensyndrom [Prenatal diagnosis of the pentalogy of Cantrell combined with exencephaly and amniotic band syndrome]","volume":"14","author":"Peer","year":"1993","journal-title":"Ultraschall Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0003-4975(93)90373-P","article-title":"Staged repair of pentalogy of Cantrell with tetralogy of Fallot","volume":"56","author":"Abdallah","year":"1993","journal-title":"Ann. Thorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/1010-7940(93)90177-D","article-title":"Left and right ventricular diverticula, ventricular septal defect and ectopia cordis in a patient with Cantrell\u2019s syndrome","volume":"7","author":"Bogers","year":"1993","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1055\/s-2007-994336","article-title":"The Cantrell-sequence: A result of maternal exposure to aminopropionitriles?","volume":"14","author":"Dembinski","year":"1997","journal-title":"Am. J. Perinatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/BF01076959","article-title":"Cantrell\u2019s pentalogy. Report of four cases and their management","volume":"12","author":"Vila","year":"1997","journal-title":"Pediatr. Surg. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0003-4975(98)00089-7","article-title":"Cantrell\u2019s syndrome: A challenge to the surgeon","volume":"65","author":"Muehler","year":"1998","journal-title":"Ann. Thorac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/(SICI)1097-0096(199810)26:8<409::AID-JCU7>3.0.CO;2-M","article-title":"Prenatal sonographic diagnosis of Cantrell\u2019s pentalogy with cystic hygroma in the first trimester","volume":"26","author":"Hsieh","year":"1998","journal-title":"J. Clin. Ultrasound"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02849710","article-title":"Pentalogy of Cantrell","volume":"65","author":"Katranci","year":"1998","journal-title":"Indian J. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1460-9592.1998.00687.x","article-title":"Anaesthetic management of a prematurely born infant with Cantrell\u2019s Pentalogy","volume":"8","author":"Laloyaux","year":"1998","journal-title":"Paediatr. Anaesth."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1096-9926(199811)58:5<205::AID-TERA7>3.0.CO;2-X","article-title":"Infant with midline thoracoabdominal schisis and limb defects","volume":"58","author":"Pivnick","year":"1998","journal-title":"Teratology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s002470000288","article-title":"MR imaging of pentalogy of Cantrell variant with an intact diaphragm and pericardium","volume":"30","author":"Song","year":"2000","journal-title":"Pediatr. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/S0066-782X2000001000007","article-title":"Cantrell syndrome. Case report of an adult","volume":"75","author":"Falcao","year":"2000","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/140174301750101546","article-title":"Left ventricular diverticulum associated with Cantrell\u2019s syndrome and tetralogy of Fallot in an adult","volume":"35","author":"Alayunt","year":"2001","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1017\/S1047951102000148","article-title":"Cardiac diverticulum and omphalocele: Cantrell\u2019s pentalogy or syndrome","volume":"12","author":"Halbertsma","year":"2002","journal-title":"Cardiol. Young"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/jmf.12.3.209.211","article-title":"Prenatal diagnosis of Cantrell\u2019s pentalogy with conventional and three-dimensional sonography","volume":"12","author":"Chedraui","year":"2002","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_21","first-page":"383","article-title":"The confused identity of Cantrell\u2019s pentad: Ectopia cordis is related either to thoracoschisis or to a diaphragmatic hernia with an omphalocele","volume":"22","author":"Davies","year":"2003","journal-title":"Pediatr. Pathol. Mol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00404-002-0400-x","article-title":"Cantrell\u2019s syndrome-report of two cases with one atypical variant","volume":"268","author":"Nanda","year":"2003","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpedsurg.2003.09.030","article-title":"Combined pentalogy of Cantrell with tetralogy of Fallot, gallbladder agenesis, and polysplenia: A case report","volume":"39","author":"Bittmann","year":"2004","journal-title":"J. Pediatr. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00019605-200401000-00018","article-title":"An infant with pentalogy of Cantrell and limb defects diagnosed prenatally","volume":"13","author":"Uygur","year":"2004","journal-title":"Clin. Dysmorphol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1136\/hrt.2004.035451","article-title":"Left ventricular diverticulum in a neonate with Cantrell syndrome","volume":"90","author":"Sekarski","year":"2004","journal-title":"Heart"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jcu.20134","article-title":"Prenatal diagnosis of pentalogy of Cantrell in three cases, two with craniorachischisis","volume":"33","author":"Polat","year":"2005","journal-title":"J. Clin. Ultrasound"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2005-916248","article-title":"Erh\u00f6hte fetale Nackentransparenz als Pr\u00e4diktor f\u00fcr eine Cantrellsche, Pentalogie\u2013eine Kasuistik","volume":"209","author":"Staboulidou","year":"2005","journal-title":"Z. Geburtsh. Neonatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1159\/000095670","article-title":"Diagnosis of Pentalogy of Cantrell by three-dimensional ultrasound in third trimester of pregnancy. A case report","volume":"21","author":"Pires","year":"2006","journal-title":"Fetal Diagn. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1510\/icvts.2005.120709","article-title":"Pentalogy of Cantrell associated with hypoplastic left heart syndrome and herniation of the ventricular mass into the abdominal cavity","volume":"5","year":"2006","journal-title":"Interact Cardiovasc Thorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00246-005-6001-2","article-title":"Cantrell\u2019s Syndrome forme fruste in a newborn diagnosed by transthoracic echocardiography and cardiac magnetic resonance imaging","volume":"27","author":"Knirsch","year":"2006","journal-title":"Pediatr. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1017\/S1047951105002192","article-title":"Cantrell\u2019s syndrome","volume":"16","author":"Marijon","year":"2006","journal-title":"Cardiol. Young"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000100788","article-title":"Prenatal and postnatal management of a patient with pentalogy of Cantrell and left ventricular aneurysm. A case report and literature review","volume":"22","author":"Grethel","year":"2007","journal-title":"Fetal Diagn. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00246-007-0016-9","article-title":"Pentalogy of Cantrell associated with hypoplastic left heart syndrome","volume":"28","author":"Wheeler","year":"2007","journal-title":"Pediatr. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000098710","article-title":"Prenatal sonographic diagnosis of a rare Cantrell\u2019s pentalogy variant with associated open neural tube defect\u2014A case report","volume":"22","author":"Loureiro","year":"2007","journal-title":"Fetal Diagn. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00246-007-9032-z","article-title":"Pentalogy of Cantrell: Successful early correction","volume":"29","author":"Korver","year":"2008","journal-title":"Pediatr. Cardiol."},{"key":"ref_36","first-page":"171","article-title":"Prenatal diagnosis of ectopia cordis: Case report","volume":"86","author":"Chelli","year":"2008","journal-title":"Tunis. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1510\/icvts.2007.171959","article-title":"Fontan operation through a right lateral thoracotomy to treat Cantrell syndrome with severe ectopia cordis","volume":"7","author":"Okamoto","year":"2008","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2459\/JCM.0b013e3282f03bd3","article-title":"Double-outlet right ventricle in a neonate with Cantrell\u2019s syndrome","volume":"9","author":"Ajovalasit","year":"2008","journal-title":"J. Cardiovasc. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1875-9572(08)60018-2","article-title":"Trisomy 18 syndrome with incomplete Cantrell syndrome","volume":"49","author":"Hou","year":"2008","journal-title":"Pediatr. Neonatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1017\/S1047951108002382","article-title":"Repair of left ventricular diverticulum in setting of Cantrell\u2019s syndrome","volume":"18","author":"Turbendian","year":"2008","journal-title":"Cardiol. Young"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/uog.6223","article-title":"Changing findings in pentalogy of Cantrell in fetal life","volume":"32","author":"Zidere","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S1028-4559(09)60025-5","article-title":"Concomitant exencephaly and limb defects associated with pentalogy of Cantrell","volume":"47","author":"Chen","year":"2008","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e483","DOI":"10.1161\/CIRCULATIONAHA.108.811000","article-title":"Images in cardiovascular medicine: Pentalogy of Cantrell associated with thoracoabdominal ectopia cordis","volume":"119","author":"Gao","year":"2009","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.bjps.2007.11.025","article-title":"Chest wall reconstruction in a patient with Cantrell syndrome","volume":"62","author":"Mitsukawa","year":"2009","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/JPN.0b013e3181a3b4e5","article-title":"Pentalogy of Cantrell: Reviewing the syndrome with a case report and nursing implications","volume":"23","author":"Meeker","year":"2009","journal-title":"J. Perinat. Neonatal Nurs."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00540-009-0785-9","article-title":"Perioperative management of a neonate with Cantrell syndrome","volume":"23","author":"Suehiro","year":"2009","journal-title":"J. Anesth."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4103\/2006-8808.63717","article-title":"Pentalogy of cantrell: A report of three cases","volume":"2","author":"Sowande","year":"2010","journal-title":"J. Surg. Tech. Case Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/jp.2010.4","article-title":"Cantrell syndrome","volume":"30","author":"Herman","year":"2010","journal-title":"J. Perinatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1747-0803.2009.00375.x","article-title":"Pentalogy of Cantrell with left ventricular diverticulum: A case report and review of literature","volume":"5","author":"Singh","year":"2010","journal-title":"Congenit. Heart Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/eurheartj\/ehq316","article-title":"Heart with a trunk: Form fruste of Cantrell\u2019s Syndrome","volume":"32","author":"Quandt","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.acvd.2010.06.008","article-title":"Late diagnosis of incomplete Cantrell\u2019s syndrome on CT scan","volume":"104","author":"Angoulvant","year":"2011","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/2150135110390528","article-title":"Pentalogy of Cantrell: Forty-two Years of Experience in the Hospital Infantil de Mexico Federico Gomez","volume":"2","year":"2011","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/ajmg.a.33895","article-title":"Co-occurrence of severe Goltz-Gorlin syndrome and pentalogy of Cantrell\u2014Case report and review of the literature","volume":"155A","author":"Smigiel","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jpedsurg.2011.03.071","article-title":"Cantrell syndrome with complex cardiac malformations: A case report","volume":"46","author":"Wen","year":"2011","journal-title":"J. Pediatr. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2350\/10-09-0914-CC.1","article-title":"Pentalogy or hexalogy of Cantrell?","volume":"14","author":"Brochut","year":"2011","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_56","first-page":"10","article-title":"Complete Pentalogy of Cantrell with craniorachischisis: A case report","volume":"6","author":"Ranganath","year":"2012","journal-title":"J. Prenat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1540-8191.2012.01456.x","article-title":"Staged repair of pentalogy of Cantrell with ectopia cordis and ventricular septal defect","volume":"27","author":"Sakasai","year":"2012","journal-title":"J. Card. Surg."},{"key":"ref_58","first-page":"145","article-title":"Prenatal diagnosis of Cantrell pentalogy in first trimester screening: Case report and review of literature","volume":"13","author":"Yeniel","year":"2012","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/2000656X.2012.703464","article-title":"Thoracoabdominoplasty with umbilicoplasty for Cantrell\u2019s syndrome","volume":"46","author":"Kinoshita","year":"2012","journal-title":"J. Plast. Surg. Hand Surg."},{"key":"ref_60","first-page":"309576","article-title":"Left Ventricle Diverticulum with Partial Cantrell\u2019s Syndrome","volume":"2012","author":"Labib","year":"2012","journal-title":"Case Rep. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/2249-4847.116410","article-title":"Pentalogy of Cantrell: An extremely rare congenital anomaly","volume":"2","author":"Chandran","year":"2013","journal-title":"J. Clin. Neonatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tjog.2013.04.029","article-title":"Discordant anencephaly and Cantrell syndrome in monozygotic twins conceived by ICSI and IVF-ET","volume":"52","author":"Chen","year":"2013","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12262-012-0688-0","article-title":"Incomplete Cantrell\u2019s Pentalogy\u2014A Case Report","volume":"75","author":"Magadum","year":"2013","journal-title":"Indian J. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.11152\/mu.2013.2066.153.mbk1vkp2","article-title":"Pentalogy of Cantrell associated with exencephaly and spinal dysraphism: Antenatal ultrasonographic diagnosis. Case report","volume":"15","author":"Kachare","year":"2013","journal-title":"Med. Ultrason."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/icvts\/ivt286","article-title":"Fontan operation for the Cantrell syndrome using a clamshell incision","volume":"17","author":"Ito","year":"2013","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.12809\/hkmj133737","article-title":"Ectopia cordis","volume":"19","author":"Puvabanditsin","year":"2013","journal-title":"Hong Kong Med. J."},{"key":"ref_67","first-page":"94","article-title":"Cardiac anomalies in Cantrell\u2019s pentalogy: From ventricular diverticulum to complete thoracic ectopia cordis","volume":"9","author":"Kaouthar","year":"2013","journal-title":"Cardiol. Tunis."},{"key":"ref_68","first-page":"314284","article-title":"Prenatal Diagnosis of Cantrell\u2019s Pentalogy Associated with Agenesis of Left Limb in a Twin Pregnancy","volume":"2014","author":"Cakiroglu","year":"2014","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_69","first-page":"85","article-title":"Pentalogy of Cantrell: Case report and review of the literature","volume":"14","author":"Kheir","year":"2014","journal-title":"Sudan. J. Paediatr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"E129","DOI":"10.1111\/chd.12101","article-title":"Pentalogy of Cantrell with ectopia cordis totalis, total anomalous pulmonary venous connection, and tetralogy of Fallot: A case report and review of the literature","volume":"9","author":"Restrepo","year":"2014","journal-title":"Congenit. Heart Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jpedsurg.2014.06.003","article-title":"Surgical treatment and outcomes of pentalogy of Cantrell in eight patients","volume":"49","author":"Zhang","year":"2014","journal-title":"J. Pediatr. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3941\/jrcr.v8i12.1972","article-title":"Pentalogy of Cantrell with Ectopia Cordis: CT Findings","volume":"8","author":"Pirasteh","year":"2014","journal-title":"J. Radiol. Case Rep."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Naburi, H., Assenga, E., Patel, S., Massawe, A., and Manji, K. (2015). Class II pentalogy of Cantrell. BMC Res. Notes, 8.","DOI":"10.1186\/s13104-015-1293-7"},{"key":"ref_74","first-page":"629561","article-title":"Coincidence of Incomplete Pentalogy of Cantrell and Meningomyelocele in a Dizygotic Twin Pregnancy","volume":"2015","author":"Timur","year":"2015","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_75","first-page":"179298","article-title":"Diagnosis of pentalogy of cantrell in the first trimester using transvaginal sonography and color Doppler","volume":"2015","year":"2015","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/15513815.2015.1122123","article-title":"Pentalogy of Cantrell with Unilateral Kidney Evisceration: A Case Report and Review of Literature","volume":"35","author":"Partlm","year":"2016","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S104795111500030X","article-title":"One-stage surgical treatment for Cantrell syndrome without repairing the left ventricular diverticulum: A case report","volume":"26","author":"Yang","year":"2016","journal-title":"Cardiol. Young"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"280","DOI":"10.18203\/2349-3291.ijcp20164620","article-title":"Pentalogy of Cantrell with single umbilical artery: A rare fetal anomaly","volume":"4","author":"Meena","year":"2016","journal-title":"Int. J. Contemp. Pediatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1055\/s-0037-1599794","article-title":"Pentalogy of Cantrell: Is Echocardiography Sufficient in the Neonatal Period?","volume":"5","author":"Zani","year":"2017","journal-title":"Eur. J. Pediatr. Surg. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1858621","DOI":"10.1155\/2017\/1858621","article-title":"Complete Ectopia Cordis: A Case Report and Literature Review","volume":"2017","author":"Pius","year":"2017","journal-title":"Case Rep. Pediatr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/1093526617689896","article-title":"Severe Intrauterine Amputations in One Dichorionic Twin With Pentalogy of Cantrell: Further Evidence and Consideration for Mechanical Teratogenesis","volume":"20","year":"2017","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_82","first-page":"191","article-title":"Two cases of Pentalogy of Cantrell diagnosed antenatally at Korle Bu Teaching Hospital, Accra","volume":"51","author":"Seffah","year":"2017","journal-title":"Ghana Med. J."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"M\u0103rginean, C., M\u0103rginean, C.O., Gozar, L., Meli\u0163, L.E., Suciu, H., Gozar, H., Cri\u015fan, A., and Cucerea, M. (2018). Cantrell Syndrome-A Rare Complex Congenital Anomaly: A Case Report and Literature Review. Front. Pediatr., 6.","DOI":"10.3389\/fped.2018.00201"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e11511","DOI":"10.1097\/MD.0000000000011511","article-title":"Pentalogy of Cantrell associated with unilateral anophthalmia: Case report and literature review","volume":"97","author":"Grigore","year":"2018","journal-title":"Medicine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1213\/XAA.0000000000000793","article-title":"Management challenges in an infant with Pentalogy of Cantrell, giant anterior encephalocele, and craniofacial anomalies: A Case Report","volume":"11","author":"Hubbard","year":"2018","journal-title":"A&A Pract."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-0039-1679878","article-title":"Ectopia Cordis Associated with Pentalogy of Cantrell\u2014A Case Report","volume":"41","author":"Madi","year":"2019","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"ref_87","first-page":"621","article-title":"Pentalogy of Cantrell with Total Ectopia Cordis and a Major Omphalocele\u2014A Case Report","volume":"7","author":"Delgado","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Kylat, R.I. (2019). Complete and Incomplete Pentalogy of Cantrell. Children, 6.","DOI":"10.3390\/children6100109"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/15513815.2019.1629132","article-title":"Trisomy 18 in a First-Trimester Fetus with Thoraco-Abdominal Ectopia Cordis","volume":"39","author":"Sepulveda","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e25470","DOI":"10.1097\/MD.0000000000025470","article-title":"The complete spectrum of pentalogy of Cantrell in one of a set of dizygotic twins: A case report of a rare congenital anomaly","volume":"100","author":"Zvizdic","year":"2021","journal-title":"Medicine"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"275","DOI":"10.18231\/j.ijogr.2021.058","article-title":"Pentalogy of Cantrell with encephalocele\u2013A case report with review of literature","volume":"8","author":"Desikan","year":"2021","journal-title":"Indian. J. Obstet. Gynecol. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"183","DOI":"10.31729\/jnma.7153","article-title":"A Baby Born with Ectopia Cordis, Omphalocele, Cleft Lips and Palate: A Case Report","volume":"60","author":"Shrestha","year":"2022","journal-title":"JNMA J. Nepal. Med. Assoc."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1016\/j.radcr.2022.05.083","article-title":"Radiological findings of partial expression pentalogy of Cantrell and other multiple congenital anomalies: A rare case report","volume":"17","author":"Sulistyowati","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/PHMT.S374289","article-title":"Pentalogy of Cantrell Associated with Ectopia Cordis: A Case Report","volume":"13","author":"Fazea","year":"2022","journal-title":"Pediatr. Health Med. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Wang, D., Zheng, B., Zhai, B., Mo, J., Yang, K., and Huo, Y. (2022). Clinical and ultrasound findings of pentalogy of Cantrell in a newborn: A case report. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.998495"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21037\/acr-23-14","article-title":"Surgical treatment of neonatal Cantrell pentalogy: A case report and literature review","volume":"7","author":"Liao","year":"2023","journal-title":"AME Case Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"108941","DOI":"10.1016\/j.ijscr.2023.108941","article-title":"The pentalogy of Cantrell: A rare and challenging prenatal diagnosis","volume":"112","author":"Mraihi","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/apc.apc_188_23","article-title":"Pulsating abdominal mass in a newborn-Pentalogy of Cantrell with left ventricular diverticulum","volume":"16","author":"Faisal","year":"2023","journal-title":"Ann. Pediatr. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Fabijan, A., Korabiewska-Pluta, S., Puzio, T., Polis, B., and Moszura, T. (2024). Images of Extremely Rare Cantrell Phenomenon. Diagnostics, 14.","DOI":"10.3390\/diagnostics14101003"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pedneo.2024.03.005","article-title":"Epignathus and thoracoabdominal ectopia cordis in a neonate","volume":"65","author":"Garofalo","year":"2024","journal-title":"Pediatr. Neonatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.radcr.2025.01.037","article-title":"Complete pentalogy of Cantrell associated with ectopia cordis and multiple anomalies: A case report from a low-resource setting","volume":"20","author":"Dusuri","year":"2025","journal-title":"Radiol. Case Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4103\/aca.aca_213_24","article-title":"Anesthesia for Pentalogy of Cantrell with Surgical Repair of Tetralogy of Fallot Along with Absent Diaphragm: A Case Study","volume":"28","author":"Maheshwari","year":"2025","journal-title":"Ann. Card. Anaesth."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"111353","DOI":"10.1016\/j.ijscr.2025.111353","article-title":"Complex management of ectopia cordis complicated by pentalogy of cantrell: Report of two cases and review of current evidence","volume":"131","author":"Martadiansyah","year":"2025","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1515\/JPM.2009.065","article-title":"Correct definition of pentalogy of Cantrell","volume":"37","author":"Duan","year":"2009","journal-title":"J. Perinat. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jcpa.2019.11.005","article-title":"Cantrell Syndrome (Thoracoabdominal Ectopia Cordis; Anomalous Umbilical Cord; Diaphragmatic, Pericardial and Intracardiac Defects) in the Pig (Sus scrofa domesticus)","volume":"174","author":"Avedillo","year":"2020","journal-title":"J. Comp. Pathol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3389\/fsurg.2022.891896","article-title":"Embryology of the Abdominal Wall and Associated Malformations\u2014A Review","volume":"9","author":"Pechriggl","year":"2022","journal-title":"Front. Surg."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.26420\/annhematoloncol.2022.1394","article-title":"Abdominal Wall Defects in Prenatal Medicine","volume":"9","author":"Solerte","year":"2022","journal-title":"Ann. Hematol. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"So, W., Donahoe, S.L., Podadera, J.M., and Mazrier, H. (2023). Pentalogy of Cantrell in Two Neonate Littermate Puppies: A Spontaneous Animal Model Suggesting Familial Inheritance. Animals, 13.","DOI":"10.3390\/ani13132091"},{"key":"ref_109","first-page":"e4004227","article-title":"New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology","volume":"52","year":"2021","journal-title":"Colomb. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ajmg.c.30182","article-title":"Gastroschisis: A gene-environment model involving the VEGF-NOS3 pathway","volume":"148","author":"Lammer","year":"2008","journal-title":"Am. J. Med. Genet. C"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/ajmg.a.36370","article-title":"A vascular and thrombotic model of gastroschisis","volume":"164","author":"Lubinsky","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_112","first-page":"294","article-title":"Gastroschisis: Abdominal wall disruption secondary to early gestational interruption of the omphalomesenteric artery","volume":"7","author":"Hoyme","year":"1983","journal-title":"Semin. Perinatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1399-0004.2008.01142.x","article-title":"Escape of the yolk sac: A hypothesis to explain the embryogenesis of gastroschisis","volume":"75","author":"Stevenson","year":"2009","journal-title":"Clin. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcpa.2019.12.003","article-title":"Body Wall Defects: Gastroschisis and Omphalocoele in Pigs (Sus scrofa domesticus)","volume":"175","author":"Avedillo","year":"2020","journal-title":"J. Comp. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/ahe.12482","article-title":"Body wall defects and amniotic band syndrome in pig (Sus scrofa domesticus)","volume":"49","author":"Avedillo","year":"2020","journal-title":"Anat. Histol. Embryol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.23.090506.123331","article-title":"Heart field: From mesoderm to heart tube","volume":"23","author":"Kirby","year":"2007","journal-title":"Ann. Rev. Cell Devel Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/CIRCGENETICS.113.000455","article-title":"A point mutation in Myh10 causes major defects in heart development and body wall closure","volume":"7","author":"Ma","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0020-7292(95)80008-Z","article-title":"Body stalk anomaly: Prenatal diagnosis","volume":"51","author":"Takeuchi","year":"1995","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/pd.2947","article-title":"Body stalk anomaly: Adverse maternal outcomes in a series of 21 cases","volume":"32","author":"Costa","year":"2012","journal-title":"Prenat. Diagn."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0971-3026.150162","article-title":"Prenatal diagnosis of body stalk complex: A rare entity and review of literature","volume":"25","author":"Kocherla","year":"2015","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gic\u0103, N., Apostol, L.M., Hulu\u021b\u0103, I., Panaitescu, A.M., Vayna, A.M., Peltecu, G., and Gana, N. (2024). Body Stalk Anomaly. Diagnostics, 14.","DOI":"10.3390\/diagnostics14050518"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e1227","DOI":"10.1002\/mgg3.1227","article-title":"Body stalk anomalies in pig-Definition and classification","volume":"8","author":"Avedillo","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e1465","DOI":"10.1002\/mgg3.1465","article-title":"Anatomy-based diagnostic criteria for complex body wall anomalies (CBWA)","volume":"8","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Alguacil, N., Cozar, J.M., and Avedillo, L. (2025). Complex Body Wall Closure Defects in Seven Dog Fetuses: An Anatomic and CT Scan Study. Animals, 15.","DOI":"10.3390\/ani15142030"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1098612X251341068","DOI":"10.1177\/1098612X251341068","article-title":"Body stalk anomalies and their relationship to amniotic band disruption complex in six cats","volume":"27","author":"Cozar","year":"2025","journal-title":"J. Feline Med. Surg."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Alguacil, N., Cozar, J.M., and Avedillo, L.J. (2025). Body Stalk Anomalies in Pigs: Current Trends and Future Directions in Classification. Animals, 15.","DOI":"10.3390\/ani15030460"},{"key":"ref_127","first-page":"559","article-title":"Repair of Congenital Diaphragmatic Hernia and Umbilical Hernia in a Dog","volume":"136","author":"Butler","year":"1960","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2460\/javma.1989.194.12.1741","article-title":"Congenital cranioventral abdominal wall, caudal sternal, diaphragmatic, pericardial, and intracardiac defects in Cocker Spaniel littermates","volume":"194","author":"Bellah","year":"1989","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5326\/JAAHA-MS-6181","article-title":"Sternal Cleft Associated with Cantrell\u2019s Pentalogy in a German Shepherd Dog","volume":"51","author":"Poncet","year":"2015","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e000896","DOI":"10.1136\/vetreccr-2019-000896","article-title":"Novel peritoneopericardial diaphragmatic hernia in a dog","volume":"7","author":"Khan","year":"2019","journal-title":"Vet. Rec. Case Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e001188","DOI":"10.1136\/vetreccr-2020-001188","article-title":"Incomplete pentalogy of Cantrell in a Border terrier puppy","volume":"8","author":"Williams","year":"2020","journal-title":"Vet. Rec. Case Rep."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Hennink, I., D\u00fcver, P., Rytz, U., Meneses, F., Moioli, M., Adamik, K.N., and Kovacevic, A. (2021). Case Report: Unusual Peritoneopericardial Diaphragmatic Hernia in an 8-Month-Old German Shepherd Dog, Associated with a Pericardial Pseudocyst and Coexisting Severe Pericardial Effusion Resulting in Right-Sided Heart Failure. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.673543"},{"key":"ref_133","first-page":"rcfcv-e34306","article-title":"Thoracic ectopia cordis, sternal agenesis, partial ectopia hepatica and fissure abdominalis in a German Shepherd puppy with milder incomplete pentalogy of Cantrell. Clinical case","volume":"XXXIV","author":"Yildirim","year":"2024","journal-title":"Rev. Cient. Fac. Cienc. Vet. Univ. Zulia"},{"key":"ref_134","first-page":"783","article-title":"Cardiac malposition (ectopia cordis) in a cat","volume":"25","author":"Lopez","year":"2015","journal-title":"J. Vet.-Emerg. Crit. Care"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2460\/javma.254.9.1099","article-title":"Congenital sternal defect repair in an adult cat with incomplete pentalogy of Cantrell","volume":"254","author":"Eiger","year":"2019","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1002\/vrc2.364","article-title":"Combined pentalogy of Cantrell with ectrodactyly and surgical implant-free repair of a sternal cleft and supraumbilical hernia in an adult cat","volume":"10","author":"Kokkinos","year":"2022","journal-title":"Vet. Rec. Case Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/030098589303000606","article-title":"Cervico-pectoral ectopia cordis in two Holstein calves","volume":"30","author":"Hiraga","year":"1993","journal-title":"Vet. Pathol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1439-0442.1992.tb00241.x","article-title":"Cardiac function, morphology and chromosomal aberrations in a calf with ectopia cordis cervicalis","volume":"39","author":"Windberger","year":"1992","journal-title":"Zentralblatt Vet. Reihe A"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/vr.142.16.437-a","article-title":"Total pectoral ectopia cordis and other congenital malformations in a calf","volume":"142","author":"Metin","year":"1998","journal-title":"Vet. Rec."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.17221\/1972-VETMED","article-title":"First report of pentalogy of Cantrell in a calf: A case report","volume":"53","author":"Floeck","year":"2008","journal-title":"Vet. Med."},{"key":"ref_141","first-page":"667","article-title":"Long-term survival of a cow with cervical ectopia cordis","volume":"52","author":"Onda","year":"2011","journal-title":"Can. Vet. J."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Cerqueira, L.A., M\u00e2cedo, I.L., Sousa, D.E.R., Amorim, H.A.L., Borges, J.R.J., Ximenes, F.H.B., C\u00e2mara, A.C.L., and Castro, M.B. (2024). Complete Thoracic Ectopia Cordis in Two Lambs. Animals, 14.","DOI":"10.3390\/ani14152213"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/dvdy.193","article-title":"Development of the amniote ventrolateral body wall","volume":"250","author":"Scaal","year":"2020","journal-title":"Dev. Dyn."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e16009","DOI":"10.7554\/eLife.16009","article-title":"Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice","volume":"5","author":"Carmona","year":"2016","journal-title":"eLife"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.sempedsurg.2007.01.004","article-title":"Diaphragm development and congenital diaphragmatic hernia","volume":"16","author":"Clugston","year":"2007","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.sempedsurg.2010.03.006","article-title":"The embryologic origin of ventral body wall defects","volume":"19","author":"Sadler","year":"2010","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/dvdy.735","article-title":"Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology","volume":"254","author":"Formstone","year":"2024","journal-title":"Dev. Dyn."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"abg1727","DOI":"10.1126\/science.abg1727","article-title":"The primitive streak and cellular principles of building an amniote body through gastrulation","volume":"374","author":"Sheng","year":"2021","journal-title":"Science"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/biolreprod\/5.2.194","article-title":"The prenatal development of the dog: Preimplantation events","volume":"5","author":"Holst","year":"1971","journal-title":"Biol. Reprod."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.theriogenology.2008.04.029","article-title":"Canine embryonic and fetal development: A review","volume":"70","author":"Pretzer","year":"2008","journal-title":"Theriogenology"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ar.23296","article-title":"Intestinal Rotation and Physiological Umbilical Herniation During the Embryonic Period","volume":"299","author":"Ueda","year":"2016","journal-title":"Anat. Rec."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s42003-021-01702-4","article-title":"Midgut development in rat embryos using microcomputed tomography","volume":"4","author":"Ginzel","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1038\/s41598-018-21948-z","article-title":"Abrogation of TGF-beta signalling in TAGLN expressing cells recapitulates Pentalogy of Cantrell in the mouse","volume":"8","author":"Aldeiri","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_154","unstructured":"Copel, J.A., D\u00e1lton, M.E., and Tutschek, B. (2018). Pentalogy of Cantrell. Obstetric Imaging: Fetal Diagnosis and Care, Elsevier. [2nd ed.]."},{"key":"ref_155","first-page":"73","article-title":"Pentalogy of Cantrell. A stillbirth case report","volume":"8","author":"Palacios","year":"2022","journal-title":"Case Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ajmg.1320420118","article-title":"Pentalogy of Cantrell and associated midline anomalies: A possible ventral midline developmental field","volume":"42","author":"Carmi","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/adc.38.198.142","article-title":"Embryology of exomphalos and allied malformations","volume":"38","author":"Duhamel","year":"1963","journal-title":"Arch. Dis. Child."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2016.05.018","article-title":"Establishment of the visceral embryonic midline is a dynamic process that requires bilaterally symmetric BMP signalling","volume":"37","author":"Arraf","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.devcel.2020.04.016","article-title":"Hedgehog signalling regulates epithelial morphogenesis to position the ventral embryonic midline","volume":"53","author":"Arraf","year":"2020","journal-title":"Dev. 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