{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:41:20Z","timestamp":1789422080751,"version":"build-2803163510"},"reference-count":336,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031691","name":"University of Veterinary Medicine Budapest","doi-asserted-by":"crossref","award":["SRF-003"],"award-info":[{"award-number":["SRF-003"]}],"id":[{"id":"10.13039\/100031691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund","award":["2025-2.1.1-EK\u00d6P-2025-00022"],"award-info":[{"award-number":["2025-2.1.1-EK\u00d6P-2025-00022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Veterinary metabolomics has redefined bile acids (BAs) from simple digestive surfactants to systemic endocrine signals within a microbial\u2013host metabolic axis. This review aims to evaluate how BA dysmetabolism acts as a central pathogenic factor in canine and feline disease. We analyze the BA pool\u2019s integrity, which depends on a specialized functional guild, primarily Peptacetobacter hiranonis, responsible for 7\u03b1-dehydroxylation. We delineate two principal pathological profiles: (1) microbial collapse, characterized by secondary bile acid (SBA) depletion and compromised farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) signaling, which exacerbates inflammation in chronic enteropathy (CE), protein-losing enteropathy (PLE), and exocrine pancreatic insufficiency (EPI); and (2) hepato-biliary spillover, wherein host-induced dysfunction results in primary bile acid (PBA) excess. Recent data have linked these disruptions to skeletal health, feline renal fibrosis, cardiac remodeling in myxomatous mitral valve disease (MMVD), and neuroinflammation in epilepsy and hepatic encephalopathy. The discovery of microbially conjugated bile acids (MCBAs) and microbial extracellular vesicles (MEVs) reveals highly specific, vesicle-mediated communication pathways impacting systemic health. Diagnostic protocols should prioritize functional profiling, including the dysbiosis index (DI), serum conjugated BA analysis, and SBA\/PBA ratios. Clinical management is moving beyond empirical fecal microbiota transplantation (FMT), towards precision synthetic microbial consortia (SynComs), neuroprotective BAs like tauroursodeoxycholic acid (TUDCA), and molecular postbiotics to restore the collaborative metabolome.<\/jats:p>","DOI":"10.3390\/vetsci13020182","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:05:46Z","timestamp":1770897946000},"page":"182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders\u2014From Mechanisms to Precision Therapeutics"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2470-4792","authenticated-orcid":false,"given":"Kriszti\u00e1n","family":"N\u00e9meth","sequence":"first","affiliation":[{"name":"Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, Istv\u00e1n u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-4753","authenticated-orcid":false,"given":"Istv\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, Istv\u00e1n u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1992-6324","authenticated-orcid":false,"given":"Katalin","family":"L\u00e1nyi","sequence":"additional","affiliation":[{"name":"Food Chain Laboratory Center, Institute of Food Chain Science, University of Veterinary Medicine Budapest, Marek J. u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogl\u00e1rka M\u00e1ria","family":"Schilling-T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, University of Veterinary Medicine Budapest, Istv\u00e1n u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-4469","authenticated-orcid":false,"given":"Szilveszter","family":"Csorba","sequence":"additional","affiliation":[{"name":"Department of Digital Food Science, Institute of Food Chain Science, University of Veterinary Medicine Budapest, Istv\u00e1n u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-2524","authenticated-orcid":false,"given":"Ivona","family":"\u017dura \u017daja","sequence":"additional","affiliation":[{"name":"Department of Physiology and Radiobiology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Sterczer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Veterinary Medicine Budapest, Istv\u00e1n u. 2, H-1078 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-008-7568-6","article-title":"Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics","volume":"65","author":"Hofmann","year":"2008","journal-title":"Cell. 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