{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:24:12Z","timestamp":1782962652950,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SELCUK UNIVERSITY SCIENTIFIC RESEARCH PROJECTS","award":["22401135"],"award-info":[{"award-number":["22401135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Background: Tooth resorption (TR) is a prevalent dental condition with under-investigated systemic implications, particularly regarding renal health. This study aimed to evaluate renal biomarkers, specifically symmetric dimethylarginine (SDMA), and the association between TR and blood parameters. Methods: Thirty-six cats (24 TR; 12 controls) were evaluated via intraoral radiography and blood analysis. Multivariable logistic regression was performed to identify independent predictors for TR, adjusting for age and sex. Results: Tooth resorption was diagnosed in 66.7% of the cats, predominantly affecting the mandibular first molars (409) and fourth premolars (108). A strong association was identified between TR stages and lesion types (p &lt; 0.001). Cats with TR exhibited significantly higher serum SDMA concentrations (p = 0.011) and significantly lower albumin levels (p &lt; 0.001) compared to controls. Hematological analysis revealed marked leukocytosis and monocytosis (p &lt; 0.001) in the TR group. Most importantly, multivariable logistic regression identified SDMA as a predictor with TR presence (p = 0.012), with each unit increase in SDMA associated with a 3.5-fold increase in the likelihood of having resorptive lesions, independent of age and sex. Conclusions: Our findings regarding the oral-renal axis emphasize that feline TR involves chronic systemic inflammation. Consequently, it should be managed as a condition with measurable systemic impacts rather than merely a localized disease.<\/jats:p>","DOI":"10.3390\/vetsci13030233","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:39:56Z","timestamp":1772455196000},"page":"233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Serum Symmetric Dimethylarginine and Tooth Resorption in Cats: An Exploratory Study on the Oral-Renal Axis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-037X","authenticated-orcid":false,"given":"Kurtulu\u015f","family":"Parlak","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine, Selcuk University, Sel\u00e7uklu, Konya 42130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-8536","authenticated-orcid":false,"given":"Murat Kaan","family":"Durgut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Sel\u00e7uklu, Konya 42130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmican","family":"Ergin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine, Selcuk University, Sel\u00e7uklu, Konya 42130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-8968","authenticated-orcid":false,"given":"Elgin Or\u00e7um","family":"Uzunlu","sequence":"additional","affiliation":[{"name":"Department of Wild Animal Diseases and Ecology, Faculty of Veterinary Medicine, Dicle University, Sur, Diyarbakir 21280, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selman","family":"Pulat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Veterinary Medicine, Selcuk University, Sel\u00e7uklu, Konya 42130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-9418","authenticated-orcid":false,"given":"Furkan \u00c7a\u011fr\u0131","family":"Be\u015foluk","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biostatistics, Faculty of Veterinary Medicine, Selcuk University, Sel\u00e7uklu, Konya 42130, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1748-5827.2001.tb02497.x","article-title":"Prevalence of odontoclastic resorptive lesions in a clinically healthy cat population","volume":"42","author":"Ingham","year":"2001","journal-title":"J. Small Anim. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/1098612X14552366","article-title":"Feline dental radiography and radiology: A primer","volume":"16","author":"Niemiec","year":"2014","journal-title":"J. Feline Med. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/vru.12387","article-title":"Computed tomography of tooth resorption in cats","volume":"57","author":"Lang","year":"2016","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0195-5616(02)00027-X","article-title":"Feline odontoclastic resorptive lesions: An unsolved enigma in veterinary dentistry","volume":"32","author":"Reiter","year":"2002","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.bdj.2013.431","article-title":"Resorption: Part 1. Pathology, classification and aetiology","volume":"214","author":"Darcey","year":"2013","journal-title":"Br. Dent. J."},{"key":"ref_6","unstructured":"American Veterinary Dental College (2022, June 23). AVDC Nomenclature Committee. Available online: https:\/\/avdc.org\/avdc-nomenclature\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0195-5616(92)50133-4","article-title":"Etiopathogenesis of feline dental resorptive lesions","volume":"22","author":"Okuda","year":"1992","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cvsm.2005.03.008","article-title":"Radiographic evaluation and treatment of feline dental resorptive lesions","volume":"35","author":"DuPont","year":"2005","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cvsm.2005.03.006","article-title":"Update on the etiology of tooth resorption in domestic cats","volume":"35","author":"Reiter","year":"2005","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jcp.21103","article-title":"The in vitro effect of pH on osteoclasts and bone resorption in the cat: Implications for the pathogenesis of FORL","volume":"213","author":"Muzylak","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-0765.2008.01123.x","article-title":"Identifying early osteoclastic resorptive lesions in feline teeth: A model for understanding the origin of multiple idiopathic root resorption","volume":"44","author":"DeLaurier","year":"2009","journal-title":"J. Periodontal Res."},{"key":"ref_12","unstructured":"Bellows, J. (2005). Tooth resorption. Feline Dentistry, John Wiley & Sons, Inc.. [2nd ed.]."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Whyte, A., Tejedor, M.T., Whyte, J., Monteagudo, L.V., and Bonastre, C. (2021). Blood parameters and feline tooth resorption: A retrospective case control study from a Spanish university hospital. Animals, 11.","DOI":"10.3390\/ani11072125"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/vcp.12333","article-title":"Renal biomarkers in domestic species","volume":"45","author":"Hokamp","year":"2016","journal-title":"Vet. Clin. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2460\/javma.238.5.601","article-title":"Association of periodontal disease with systemic health indices in dogs and the systemic response to treatment of periodontal disease","volume":"238","author":"Rawlinson","year":"2011","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_16","first-page":"931","article-title":"Associations between feline tooth resorption and dietary, lifestyle and health factors","volume":"12","author":"Peralta","year":"2010","journal-title":"J. Feline Med. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e70030","DOI":"10.1111\/jvim.70030","article-title":"Association of Serum Symmetric Dimethylarginine Concentrations and Inflammation in Cats","volume":"39","author":"Cattaneo","year":"2025","journal-title":"J. Vet. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rosenthal, R. (1991). Meta-Analytic Procedures for Social Research, SAGE Publications.","DOI":"10.4135\/9781412984997"},{"key":"ref_19","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum Associates. [2nd ed.]."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11135-006-9018-6","article-title":"A caution regarding rules of thumb for variance inflation factors","volume":"41","year":"2007","journal-title":"Qual. Quant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/jvim.13917","article-title":"Risk factors for development of chronic kidney disease in cats","volume":"30","author":"Finch","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"ref_23","first-page":"110","article-title":"Feline internal medicine and the oral cavity","volume":"39","author":"Perry","year":"2017","journal-title":"Practice"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/jvim.12445","article-title":"Comparison of serum symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease","volume":"28","author":"Hall","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jvim.13942","article-title":"Serum Concentrations of Symmetric Dimethylarginine and Creatinine in Dogs with Naturally Occurring Chronic Kidney Disease","volume":"30","author":"Hall","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Grimm, K.A., Lamont, L.A., Tranquilli, W.J., Greene, S.A., and Robertson, S.A. (2015). Sedatives and tranquilizers. Lumb and Jones\u2019 Veterinary Anesthesia and Analgesia, Wiley-Blackwell. [5th ed.].","DOI":"10.1002\/9781119421375"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidine in the dog: A dose-response study","volume":"27","author":"Pypendop","year":"1998","journal-title":"Vet. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/jvim.14694","article-title":"Plasma Symmetric Dimethylarginine Concentration in Dogs with Acute Kidney Injury and Chronic Kidney Disease","volume":"31","author":"Dahlem","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.2460\/javma.2000.217.1866","article-title":"Prevalence of odontoclastic resorptive lesions and companion periodontal disease in cats","volume":"217","author":"Lommer","year":"2000","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0195-5616(92)50134-6","article-title":"Feline dental resorptive lesions: Prevalence patterns","volume":"22","author":"Harvey","year":"1992","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_31","first-page":"220","article-title":"Diagnostic yield of full-mouth radiography in cats","volume":"33","author":"Eriksson","year":"2016","journal-title":"J. Vet. Dent."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2460\/ajvr.2005.66.1446","article-title":"Evaluation of whole blood calcium and systemic and intraoral bone mineral density in cats with and without dental resorptive lesions","volume":"66","author":"Reiter","year":"2005","journal-title":"Am. J. Vet. Res."},{"key":"ref_33","first-page":"695","article-title":"Diagnostic value of full-mouth radiography in cats","volume":"59","author":"Verstraete","year":"1998","journal-title":"Am. J. Vet. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100369","DOI":"10.1016\/j.tcam.2019.100369","article-title":"Tooth resorption in Spanish domestic cats: Preliminary data","volume":"38","author":"Whyte","year":"2020","journal-title":"Top. Companion Anim. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1111\/jvim.12446","article-title":"Relationship between serum symmetric dimethylarginine concentration and glomerular filtration rate in cats","volume":"28","author":"Braff","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: Current knowledge and future perspectives","volume":"34","author":"Ceron","year":"2005","journal-title":"Vet. Clin. Pathol."},{"key":"ref_37","first-page":"160","article-title":"Relationship between serum adiponectin and acute phase proteins in obese cats","volume":"13","author":"Tvarijonaviciute","year":"2011","journal-title":"J. Feline Med. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4300\/JGME-D-12-00156.1","article-title":"Using effect size\u2014Or why the p value is not enough","volume":"4","author":"Sullivan","year":"2012","journal-title":"J. Grad. Med. Educ."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/3\/233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:54:27Z","timestamp":1772632467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/3\/233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["vetsci13030233"],"URL":"https:\/\/doi.org\/10.3390\/vetsci13030233","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]}}}