{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:46:19Z","timestamp":1781113579461,"version":"3.54.1"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Program on Science and Technology Innovation Capacity Building of BAAFS","award":["KJCX 20240339"],"award-info":[{"award-number":["KJCX 20240339"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFD130040311"],"award-info":[{"award-number":["2022YFD130040311"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Capacity Building\u2014Science and Technology Research Project of BAAFS","award":["KJCX20251005"],"award-info":[{"award-number":["KJCX20251005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Astragalus is a traditional Chinese medicine that contains various bioactive compounds, which exert antioxidant and immunomodulatory properties. This research aimed to investigate the impacts of Astragalus crude extract on growth performance, nutrient digestibility, immune response, and intestinal health in weaned piglets. Sixty crossbred weaned piglets at 28 days of age (8.12 \u00b1 0.14 kg) were allocated into three dietary treatments: a control group fed a corn\u2013soybean meal-based diet (CON), an antibiotic group received the basal diet with 1000 mg\/kg aureomycin (AN), and a treatment group administered the basal diet with 500 mg\/kg Astragalus crude extract (CE), with 5 replicates per group, 4 piglets per replicate. The experimental trial lasted for 28 days. Feed intake and body weight were recorded to evaluate growth performance. Blood, intestine, and liver tissue samples were collected for the analysis of antioxidant capacity and gene expression. Compared to the CON group, supplementation with CE or AN significantly enhanced growth performance and decreased diarrhea incidence on days 0\u201314, whereas only CE tended to improve crude protein digestibility. Piglets supplemented with AN or CE showed improved antioxidant capacity and immune response relative to the CON group, as evidenced by increased liver and intestinal antioxidant enzyme activities, upregulated intestinal antioxidant gene expression, and enhanced plasma immunoglobulin A levels. Further, the upregulated intestinal tight junction protein expression was observed in CE or AN groups compared with the CON. Notably, dietary CE significantly modulated gut microbiota composition, particularly enriching the genera Blautia, Turicibacter, Agathobacter, and Clostridium. These findings indicate that dietary Astragalus crude extract promotes the gut health of weaned piglets by reducing oxidative stress and modulating gut microbiota composition, thereby decreasing diarrhea incidence and improving growth performance.<\/jats:p>","DOI":"10.3390\/vetsci13030242","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:45:12Z","timestamp":1772531112000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary Astragalus Crude Extract Boosts Piglet Growth and Mitigates Weaning Stress by Enhancing Antioxidant Activity, Improving Immunity, and Modulating Intestinal Microbiota"],"prefix":"10.3390","volume":"13","author":[{"given":"Yuyan","family":"Che","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China"},{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China"},{"name":"Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resources of Oklahoma State University, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-7173","authenticated-orcid":false,"given":"Long","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China"},{"name":"Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resources of Oklahoma State University, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China"},{"name":"Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resources of Oklahoma State University, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China"},{"name":"Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resources of Oklahoma State University, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lufang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Technology, Feed Branch of Beijing Sanyuan Breeding Technology Co., Ltd., Beijing 100163, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China"},{"name":"Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resources of Oklahoma State University, Beijing 100097, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/jsfa.10904","article-title":"Chemical composition and protective effect of guava (Psidium guajava L.) leaf extract on piglet intestines","volume":"101","author":"Wang","year":"2021","journal-title":"J. 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