{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:19:26Z","timestamp":1785406766857,"version":"3.56.0"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianchi Talent Program","award":["BT-2025-TCYC-0051"],"award-info":[{"award-number":["BT-2025-TCYC-0051"]}]},{"name":"President\u2019s Fund of Tarim University","award":["TDZKBS202527"],"award-info":[{"award-number":["TDZKBS202527"]}]},{"award":["TDZKBS202527"],"award-info":[{"award-number":["TDZKBS202527"]}],"id":[{"id":"https:\/\/ror.org\/05202v862","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Xinjiang Talent Development Fund","award":["525302020"],"award-info":[{"award-number":["525302020"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772700"],"award-info":[{"award-number":["31772700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["31772700"],"award-info":[{"award-number":["31772700"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The oncogenic Marek\u2019s disease virus (MDV) triggers Marek\u2019s disease (MD), which is a substantial threat to poultry as it transforms infected T cells into tumors. Our research identified that long non-coding RNA 9802 (lncRNA-9802) exhibits increased expression in the chicken spleen following MDV infection, with its expression being strongly associated with the expression of tumor p53-binding protein 1 (TP53BP1). The function of lncRNA-9802 in T cells transformed by MDV remains unclear. Consequently, the expression levels of lncRNA-9802 were either over-expressed or knocked down in MDV-transformed T cells, MDCC-MSB1, through lentivirus-mediated over-expression and knock down experiments. Our findings demonstrate that lncRNA-9802 induces proliferation disturbances in MDCC-MSB1 cells by causing arrest in the S phase, which is accompanied by increased expression levels of TP53BP1, p53, and p21. Activation of the p53 pathway results in elevated levels of Cyclin E and Cyclin-dependent kinase 2 (CDK2), thereby facilitating the entry of MDCC-MSB1 cells into the S phase. Concurrently, the reduced levels of Cyclin A inhibit the exit of MDCC-MSB1 cells from the S phase. By modulating the TP53BP1\/p53\/p21 pathway, lncRNA-9802 induces S phase arrest in MDCC-MSB1 cells, characterized by upregulation of Cyclin E and CDK2 and downregulation of Cyclin A. This research enhances the understanding of the pathogenic mechanisms of MDV and provides a foundation for identifying potential targets for antiviral drug development.<\/jats:p>","DOI":"10.3390\/vetsci13050469","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:44:26Z","timestamp":1778658266000},"page":"469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chicken lncRNA-9802 Induces the S Phase Arrest in the T Lymphocyte Cells Infected by Marek\u2019s Disease Virus via the TP53BP1\/p53\/p21 Pathway"],"prefix":"10.3390","volume":"13","author":[{"given":"Shuo","family":"Han","sequence":"first","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science and Technology, Tarim University, Alar 843300, China"},{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haile","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science and Technology, Tarim University, Alar 843300, China"},{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Changchun Normal University, Changchun 130032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.5455\/OVJ.2025.v15.i10.2","article-title":"Marek\u2019s disease: A global challenge to poultry health and productivity","volume":"15","author":"Mulyati","year":"2025","journal-title":"Open Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Song, B., Zeb, J., Hussain, S., Aziz, M.U., Circella, E., Casalino, G., Camarda, A., Yang, G., Buchon, N., and Sparagano, O. (2022). A review on the Marek\u2019s disease outbreak and its virulence-related meq genovariation in Asia between 2011 and 2021. Animals, 12.","DOI":"10.3390\/ani12050540"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, J.L., Teng, M., Zheng, L.P., Zhu, F.X., Ma, S.X., Li, L.Y., Zhang, Z.H., Chai, S.J., Yao, Y., and Luo, J. (2023). Emerging hypervirulent Marek\u2019s disease virus variants significantly overcome protection conferred by commercial vaccines. Viruses, 15.","DOI":"10.3390\/v15071434"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1637\/11525-110216-Reg.1","article-title":"Industry-wide surveillance of Marek\u2019s disease virus on commercial poultry farms","volume":"61","author":"Kennedy","year":"2017","journal-title":"Avian Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"N\u00fa\u00f1ez-Mart\u00ednez, H.N., and Recillas-Targa, F. (2022). Emerging functions of lncRNA loci beyond the transcript itself. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116258"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/15376516.2023.2197489","article-title":"Long noncoding RNAs: Biogenesis, regulation, function, and their emerging significance in toxicology","volume":"33","author":"Choudhuri","year":"2023","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13046-024-03190-w","article-title":"LncOCMRL1 promotes oral squamous cell carcinoma growth and metastasis via the RRM2\/EMT pathway","volume":"43","author":"Lu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41590-025-02355-9","article-title":"Long noncoding RNA regulation of immunity","volume":"27","author":"Yu","year":"2026","journal-title":"Nat. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e23063","DOI":"10.1096\/fj.202201680R","article-title":"A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression","volume":"37","author":"Wen","year":"2023","journal-title":"FASEB J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sarma, A., Suri, P., Justice, M., Angamuthu, R., and Pushparaj, S. (2025). An emphasis on the role of long non-coding RNAs in viral gene expression, pathogenesis, and innate immunity in viral chicken diseases. Non-Coding RNA, 11.","DOI":"10.3390\/ncrna11030042"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10294","DOI":"10.1038\/s41598-017-10900-2","article-title":"Long intergenic non-coding RNA GALMD3 in chicken Marek\u2019s disease","volume":"7","author":"Han","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"He, Y., Han, B., Ding, Y., Zhang, H., Chang, S., Zhang, L., Zhao, C., Yang, N., and Song, J. (2019). Linc-GALMD1 regulates viral gene expression in the chicken. Front. Genet., 10.","DOI":"10.3389\/fgene.2019.01122"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1080\/15476286.2016.1244600","article-title":"Alternative splicing of a viral mirtron differentially affects the expression of other microRNAs from its cluster and of the host transcript","volume":"13","author":"Rasschaert","year":"2016","journal-title":"RNA Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1099\/jgv.0.000606","article-title":"Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek\u2019s disease virus","volume":"97","author":"Figueroa","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/03079457.2024.2316817","article-title":"Novel lncRNA 803 related to Marek\u2019s disease inhibits apoptosis of DF-1 cells","volume":"53","author":"Han","year":"2024","journal-title":"Avian Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105047","DOI":"10.1016\/j.rvsc.2023.105047","article-title":"The novel lncRNA-9802\/miR-1646 axis affects cell proliferation of DF-1 by regulating Bax\/Bcl-2 signaling pathway","volume":"164","author":"Han","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhang, H., Liu, M., Zhang, H., Cao, S., Li, Y., Jiang, S., Song, Y., and Liu, S. (2020). Detection of p53 mutation and serum monitoring alert caused by Marek\u2019s disease virus in poultry. BMC Vet. Res., 16.","DOI":"10.1186\/s12917-020-02520-2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1743-422X-7-348","article-title":"The Meq oncoprotein of Marek\u2019s disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities","volume":"7","author":"Deng","year":"2010","journal-title":"Virol. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1093\/nar\/gkac160","article-title":"ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination","volume":"50","author":"Lee","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115452","DOI":"10.1016\/j.celrep.2025.115452","article-title":"DSCC1 restrains 53BP1\/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair","volume":"44","author":"Tian","year":"2025","journal-title":"Cell Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1126\/science.add9528","article-title":"Control of cell proliferation by memories of mitosis","volume":"383","author":"Meitinger","year":"2024","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116090","DOI":"10.1016\/j.celrep.2025.116090","article-title":"Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling","volume":"44","author":"Galarreta","year":"2025","journal-title":"Cell Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1083\/jcb.201604054","article-title":"A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis","volume":"214","author":"Lambrus","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-024-02080-z","article-title":"Cyclin-dependent protein kinases and cell cycle regulation in biology and disease","volume":"10","author":"Pellarin","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115103","DOI":"10.1016\/j.celrep.2024.115103","article-title":"Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis","volume":"44","author":"Serizay","year":"2025","journal-title":"Cell Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100030","DOI":"10.1016\/j.pharmr.2024.100030","article-title":"Cell cycle dysregulation in cancer","volume":"77","author":"Glaviano","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/ERC-20-0517","article-title":"Novel insights in cell cycle dysregulation during prostate cancer progression","volume":"28","author":"Venkadakrishnan","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, S., Ran, M.Y., and Qiao, H. (2023). A cell cycle-related lncRNA signature predicts the progression-free interval in papillary thyroid carcinoma. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1110987"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/10985549.2024.2383773","article-title":"MANCR lncRNA modulates cell-cycle progression and metastasis by Cis-regulation of nuclear Rho-GEF","volume":"44","author":"Singh","year":"2024","journal-title":"Mol. Cell. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Schat, K.A. (2022). The iImportance of the bursa of fabricius, B cells and T cells for the pathogenesis of Marek\u2019s disease: A review. Viruses, 14.","DOI":"10.3390\/v14092015"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Tien, Y.T., Akbar, H., and Jarosinski, K.W. (2023). Temperature-induced reactivation of Marek\u2019s disease virus-transformed T cells ex vivo. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1145757"},{"key":"ref_32","first-page":"105","article-title":"Two cell lines from lymphomas of Marek\u2019s disease","volume":"17","author":"Akiyama","year":"1974","journal-title":"Biken J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1099\/vir.0.007831-0","article-title":"MicroRNAs 221 and 222 target p27Kip1 in Marek\u2019s disease virus-transformed tumour cell line MSB-1","volume":"90","author":"Lambeth","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1348-0421.1991.tb01596.x","article-title":"Nucleosomal structure of Marek\u2019s disease virus genome in transformed lymphoblastoid cell lines, MDCC-MSB1 and MDCC-RP1","volume":"35","author":"Hayashi","year":"1991","journal-title":"Microbiol. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hu, Y., Song, W., Zhang, L., Yuan, L., and Jin, Y. (2026). The establishment of Asian black bear (Ursus thibetanus) fibroblast cell line. Animals., 16.","DOI":"10.3390\/ani16030436"},{"key":"ref_36","first-page":"354","article-title":"Lentiviral vector-mediated transduction of adult neural stem\/progenitor cells isolated from the temporal tissues of epileptic patients","volume":"23","author":"Abdolahi","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1308","DOI":"10.31661\/gmj.v8i0.1308","article-title":"Induced overexpression of THAP11 in human fibroblast cells enhances expression of key pluripotency genes","volume":"8","author":"Ziaei","year":"2019","journal-title":"Galen Med. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/viro.1998.9290","article-title":"The DF-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses","volume":"248","author":"Himly","year":"1998","journal-title":"Virology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/jvi.70.2.1125-1131.1996","article-title":"Marek\u2019s disease virus (MDV) ICP4, pp38, and meq genes are involved in the maintenance of transformation of MDCC-MSB1 MDV-transformed lymphoblastoid cells","volume":"70","author":"Xie","year":"1996","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sato, J., Motai, Y., Yamagami, S., Win, S.Y., Horio, F., Saeki, H., Maekawa, N., Okagawa, T., Konnai, S., and Ohashi, K. (2025). Programmed cell eeath-1 expression in T-cell subsets in chickens infected with Marek\u2019s disease virus. Pathogens, 14.","DOI":"10.3390\/pathogens14050431"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10999","DOI":"10.1093\/nar\/gkae721","article-title":"Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair","volume":"52","author":"Hathaway","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41586-023-06274-3","article-title":"Loss of CDK4\/6 activity in S\/G2 phase leads to cell cycle reversal","volume":"619","author":"Cornwell","year":"2023","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10985549.2023.2196204","article-title":"DNA damage-induced, S-phase specific phosphorylation of Orc6 is critical for the maintenance of genome stability","volume":"43","author":"Lin","year":"2023","journal-title":"Mol. Cell. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.canlet.2020.12.033","article-title":"Cancer-associated 53BP1 mutations induce DNA damage repair defects","volume":"501","author":"Zhang","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ccell.2024.04.009","article-title":"Understanding the complexity of p53 in a new era of tumor suppression","volume":"42","author":"Liu","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhang, H., Xu, J., Long, Y., Maimaitijiang, A., Su, Z., Li, W., and Li, J. (2024). Unraveling the guardian: p53\u2019s multifaceted role in the DNA damage response and tumor treatment strategies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312928"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1016\/j.molcel.2025.07.023","article-title":"A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision","volume":"85","author":"Vorhauser","year":"2025","journal-title":"Mol. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-2736-5_1","article-title":"Cell cycle progression and synchronization: An overview","volume":"2579","author":"Wang","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tcb.2013.03.002","article-title":"Cell cycle control across the eukaryotic kingdom","volume":"23","author":"Harashima","year":"2013","journal-title":"Trends Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Liu, Y., Zeng, J., Ren, S., Wei, L., Wang, F., Sun, X., Huang, Y., Jiang, H., and Sui, X. (2023). Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0\/G1 phase cell cycle arrest. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04245-9"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12032-024-02338-0","article-title":"Citalopram, an antipsychotic agent, induces G1\/G0 phase cell cycle arrest and promotes apoptosis in human laryngeal carcinoma HEP-2 cells","volume":"41","author":"Salama","year":"2024","journal-title":"Med. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcancer.2024.02.002","article-title":"The cell cycle revisited: DNA replication past S phase preserves genome integrity","volume":"99","author":"Bournaka","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101706","DOI":"10.1016\/j.gendis.2025.101706","article-title":"The roles of cell cycle proteins in regulating the tumor immune microenvironment","volume":"13","author":"Zhu","year":"2026","journal-title":"Genes Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s43556-026-00411-w","article-title":"Tumor cell cycle regulation: Integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies","volume":"7","author":"Wan","year":"2026","journal-title":"Mol. Biomed."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Fagundes, R., and Teixeira, L.K. (2021). Cyclin E\/CDK2: DNA replication, replication stress and genomic instability. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.774845"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Susanti, N.M.P., and Tjahjono, D.H. (2021). Cyclin-dependent kinase 4 and 6 inhibitors in cell cycle dysregulation for breast cancer treatment. Molecules, 26.","DOI":"10.3390\/molecules26154462"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.1038\/s41467-024-51135-w","article-title":"Cryo-EM structure of the CDK2-cyclin A-CDC25A complex","volume":"15","author":"Rowland","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1158\/0008-5472.CAN-23-1331","article-title":"PICH activates cyclin A1 transcription to drive S-phase progression and chemoresistance in gastric cancer","volume":"83","author":"Ye","year":"2023","journal-title":"Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41586-025-09433-w","article-title":"Targeting G1-S-checkpoint-compromised cancers with cyclin A\/B RxL inhibitors","volume":"646","author":"Singh","year":"2025","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/15384101.2019.1693119","article-title":"Aberrant activation of cyclin A-CDK induces G2\/M-phase checkpoint in human cells","volume":"19","author":"Akaike","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.32725\/jab.2021.013","article-title":"Falcarindiol and dichloromethane fraction are bioactive components in Oplopanax elatus: Colorectal cancer chemoprevention via induction of apoptosis and G2\/M cell cycle arrest mediated by cyclin A upregulation","volume":"19","author":"Wang","year":"2021","journal-title":"J. Appl. Biomed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.immuni.2025.02.026","article-title":"The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2","volume":"58","author":"Hu","year":"2025","journal-title":"Immunity"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/5\/469\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:47:22Z","timestamp":1778662042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/5\/469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["vetsci13050469"],"URL":"https:\/\/doi.org\/10.3390\/vetsci13050469","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}