{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:03:03Z","timestamp":1784124183842,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"earmarked fund for CARS","award":["CARS-46"],"award-info":[{"award-number":["CARS-46"]}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, CAFS","doi-asserted-by":"crossref","award":["2026XT0702"],"award-info":[{"award-number":["2026XT0702"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>Malondialdehyde (MDA) is a common oxidation product in deteriorated aquatic feed, which easily induces oxidative damage and quality deterioration in farmed fish, yet its systemic effects on the physiological function and body color of channel catfish (Ictalurus punctatus) remain poorly understood. This study aimed to investigate the influences of dietary exogenous MDA on antioxidant capacity, immune function and body coloration of channel catfish. A 30-day feeding trial was carried out with four dietary MDA levels of 0, 22.3, 44.6 and 66.8 mg\/kg. Relevant physiological and pigment indices of skin and muscle were determined. Exogenous MDA significantly increased plasma transaminase levels and tissue MDA content, decreased antioxidant enzyme activities, and altered the transcription of antioxidant and immune-related genes in skin and muscle, causing oxidative stress and immune dysfunction. It also suppressed tyrosinase activity, downregulated melanin-synthesis-related genes, reduced melanin deposition and promoted uranidin accumulation in the two tissues. Collectively, dietary exogenous MDA impairs antioxidant and immune performance, disrupts pigment metabolism, and ultimately leads to body yellowing in channel catfish.<\/jats:p>","DOI":"10.3390\/vetsci13070632","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:11:57Z","timestamp":1782785517000},"page":"632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Exogenous MDA Supplementation to Diet on Antioxidant Capacity, Immunity and Body Color of Channel Catfish (Ictalurus punctatus)"],"prefix":"10.3390","volume":"13","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tongwei Agricultural Development Co., Ltd., Key Laboratory of Aquatic Nutrition and Smart Farming, Ministry of Agriculture and Rural Affairs, Aquatic Health and Intelligent Aquaculture Key Laboratory of Sichuan Province, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Xue","sequence":"additional","affiliation":[{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2649-4707","authenticated-orcid":false,"given":"Leimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2405-4221","authenticated-orcid":false,"given":"Dongyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Mi","sequence":"additional","affiliation":[{"name":"Tongwei Agricultural Development Co., Ltd., Key Laboratory of Aquatic Nutrition and Smart Farming, Ministry of Agriculture and Rural Affairs, Aquatic Health and Intelligent Aquaculture Key Laboratory of Sichuan Province, Chengdu 610093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-3914","authenticated-orcid":false,"given":"Hualiang","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"},{"name":"Key Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Skrzynska, A.K., Maiorano, E., Bastaroli, M., Naderi, F., M\u00edguez, J.M., Mart\u00ednez-Rodr\u00edguez, G., Mancera, J.M., and Martos-Sitcha, J.A. 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