{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:03:44Z","timestamp":1785243824204,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet. Sci.","Veterinary Sciences"],"abstract":"<jats:p>Functional pheochromocytoma is an uncommon canine adrenal tumor associated with substantial surgical and anesthetic challenges. This report describes two dogs with suspected functional pheochromocytoma that exhibited distinct causes of surgical complexity. Both underwent endocrine evaluation, contrast-enhanced CT, adrenalectomy, and histopathology. In Case 1, severe perivascular adhesion resulted in an iatrogenic caudal vena cava laceration despite the absence of definitive vascular invasion, requiring primary venorrhaphy. In Case 2, marked tumor-induced vascular distortion obscured critical anatomical landmarks, necessitating staged surgical management. Three-dimensional vascular reconstruction facilitated refinement of the surgical approach, while individualized anesthetic management enabled successful surgery despite marked intraoperative hemodynamic fluctuations. Histopathology confirmed pheochromocytoma in both dogs, including malignant pheochromocytoma in Case 2. Case 1 developed chronic kidney disease during long-term follow-up, whereas no clinical evidence of local recurrence or distant metastasis was observed during the available follow-up. These cases demonstrate that surgical complexity may arise from severe perivascular adhesion and tumor-induced vascular distortion, even without planned vascular lumen entry or advanced vascular procedures. Patient-specific anatomical assessment, individualized perioperative planning, and selective 3D vascular reconstruction may improve surgical safety in complex adrenal tumors.<\/jats:p>","DOI":"10.3390\/vetsci13080749","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:45:26Z","timestamp":1785239126000},"page":"749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis, Perioperative Management, and Surgical Treatment of Suspected Functional Pheochromocytoma in Two Dogs: Surgical Complexity in the Absence of Planned Venotomy"],"prefix":"10.3390","volume":"13","author":[{"given":"Hyungsan","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6491-2695","authenticated-orcid":false,"given":"Beom-Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yookyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-9958","authenticated-orcid":false,"given":"Hwi-Yool","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","unstructured":"Vail, D.M., Thamm, D.H., and Liptak, J.M. (2020). Withrow and MacEwen\u2019s Small Animal Clinical Oncology, Elsevier. [6th ed.]."},{"key":"ref_2","first-page":"2","article-title":"Canine Phaeochromocytoma: A Guide to Diagnosis and Treatment","volume":"29","author":"Galac","year":"2024","journal-title":"Companion Anim."},{"key":"ref_3","unstructured":"Ettinger, S.J., C\u00f4t\u00e9, \u00c9., and Feldman, E.C. (2024). Ettinger\u2019s Textbook of Veterinary Internal Medicine, Elsevier. [9th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1939-1676.1997.tb00464.x","article-title":"Pheochromocytoma in Dogs: 61 Cases (1984\u20131995)","volume":"11","author":"Barthez","year":"1997","journal-title":"J. Vet. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1939-1676.1994.tb03222.x","article-title":"Pheochromocytoma in 50 Dogs","volume":"8","author":"Gilson","year":"1994","journal-title":"J. Vet. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1939-1676.2008.0182.x","article-title":"Predictive Factors and the Effect of Phenoxybenzamine on Outcome in Dogs Undergoing Adrenalectomy for Pheochromocytoma","volume":"22","author":"Herrera","year":"2008","journal-title":"J. Vet. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2460\/javma.242.12.1715","article-title":"Evaluation of Risk Factors for Outcome Associated with Adrenal Gland Tumors with or without Invasion of the Caudal Vena Cava and Treated via Adrenalectomy in Dogs: 86 Cases (1993\u20132009)","volume":"242","author":"Barrera","year":"2013","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_8","unstructured":"Duprey, L.P. (2019). Small Animal Surgery, Elsevier. [5th ed.]."},{"key":"ref_9","unstructured":"Johnston, S.A., and Tobias, K.M. (2018). Veterinary Surgery: Small Animal, Elsevier. [2nd ed.]."},{"key":"ref_10","unstructured":"Hermanson, J.W., De Lahunta, A., and Evans, H.E. (2020). Miller and Evans\u2019 Anatomy of the Dog, Elsevier."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2460\/javma.2003.223.654","article-title":"Surgical Management of Adrenal Gland Tumors with and without Associated Tumor Thrombi in Dogs: 40 Cases (1994\u20132001)","volume":"223","author":"Kyles","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2460\/javma.239.2.216","article-title":"Adrenalectomy in Dogs with Adrenal Gland Tumors: 52 Cases (2002\u20132008)","volume":"239","author":"Massari","year":"2011","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/vsu.13168","article-title":"Variations in Surgical Technique for Adrenalectomy with Caudal Vena Cava Venotomy in 19 Dogs","volume":"48","author":"Knight","year":"2019","journal-title":"Vet. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/vsu.13593","article-title":"Renal Venotomy for Thrombectomy and Kidney Preservation in Dogs with Adrenal Tumors and Renal Vein Invasion","volume":"50","author":"Chiti","year":"2021","journal-title":"Vet. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/vsu.12728","article-title":"Phrenicoabdominal Venotomy for Tumor Thrombectomy in Dogs with Adrenal Neoplasia and Suspected Vena Caval Invasion","volume":"47","author":"Mayhew","year":"2018","journal-title":"Vet. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/jvim.16371","article-title":"Prediction of Vascular Invasion Using a 7-Point Scale Computed Tomography Grading System in Adrenal Tumors in Dogs","volume":"36","author":"Pey","year":"2022","journal-title":"J. Vet. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1740-8261.2009.01593.x","article-title":"Contrast-Enhanced Computed Tomography as a Preoperative Indicator of Vascular Invasion from Adrenal Masses in Dogs","volume":"50","author":"Schultz","year":"2009","journal-title":"Vet. Radiol. Ultrasound"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.21037\/qims-23-1667","article-title":"Preoperative 3-Dimensional Visualization Technology-Assisted Laparoscopic Resection of Ectopic Pheochromocytoma Surrounding the Renal Artery: A Case Description","volume":"14","author":"Huang","year":"2024","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_19","first-page":"665","article-title":"Evaluation of a Large Adrenal Carcinoma with 3D Reconstruction of Computed Tomography Images: A Case Report and Literature Review","volume":"24","author":"Chen","year":"2016","journal-title":"J. Xray Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/00480169.2025.2511195","article-title":"Patient-Specific Three-Dimensional-Printed Models for Canine Adrenalectomy: A Report of Three Cases","volume":"73","author":"Rigo","year":"2025","journal-title":"N. Z. Vet. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13304-025-02386-9","article-title":"Three-Dimensional Image Guidance for Diagnosis and Treatment of Adrenal Disease: A Systematic Review","volume":"78","author":"Zarin","year":"2026","journal-title":"Updates Surg."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Maidanskaia, E.G., Spadavecchia, C., Vincenti, S., and Mirra, A. (2022). Anaesthetic Management of a Labrador Retriever Undergoing Adrenalectomy for Phaeochromocytoma Excision, a Case Report. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.789101"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.5455\/OVJ.2024.v14.i6.17","article-title":"Anesthetic Management of a Dog Undergoing Unilateral Adrenalectomy for Phaeochromocytoma Excision Using a Partial Intravenous Anesthetic Protocol","volume":"14","author":"Gavet","year":"2024","journal-title":"Open Vet. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/jvim.12192","article-title":"Diagnosis of Spontaneous Canine Hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal)","volume":"27","author":"Behrend","year":"2013","journal-title":"J. Vet. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1939-1676.2010.0578.x","article-title":"Urinary Catecholamine and Metanephrine to Creatinine Ratios in Dogs with Hyperadrenocorticism or Pheochromocytoma, and in Healthy Dogs","volume":"24","author":"Quante","year":"2010","journal-title":"J. Vet. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/vec.12795","article-title":"Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 3\u2014Defining Antithrombotic Protocols","volume":"29","author":"Blais","year":"2019","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4097\/kjae.2012.63.6.555","article-title":"Dexmedetomidine and Remifentanil in the Perioperative Management of an Adolescent Undergoing Resection of Pheochromocytoma -A Case Report-","volume":"63","author":"Jung","year":"2012","journal-title":"Korean J. Anesthesiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jclinane.2009.01.017","article-title":"Dexmedetomidine and Magnesium Sulfate in the Perioperative Management of a Child Undergoing Laparoscopic Resection of Bilateral Pheochromocytomas","volume":"22","author":"Bryskin","year":"2010","journal-title":"J. Clin. Anesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1053\/j.jvca.2015.06.024","article-title":"Dexmedetomidine, Remifentanil, and Sevoflurane in the Perioperative Management of a Patient During a Laparoscopic Pheochromocytoma Resection","volume":"29","author":"Ozgul","year":"2015","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_30","first-page":"1","article-title":"Unilateral Nephrectomy in Dogs Is Associated with a High Rate of Intraoperative and Postoperative Complications","volume":"262","author":"Johnson","year":"2024","journal-title":"JAVMA"}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/8\/749\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:19:39Z","timestamp":1785241179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/13\/8\/749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["vetsci13080749"],"URL":"https:\/\/doi.org\/10.3390\/vetsci13080749","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}